Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anneli Kojo"'
Publikováno v:
Biochemical Pharmacology. 51:1137-1143
We studied the response of male DBA/2N mouse liver monooxygenases to acute (one-day) and subacute (7-day) exposure to clofibrate, gemfibrozil, and corn oil. The day following a single treatment with clofibrate (200 mg/kg), coumarin 7-hydroxylase (COH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67595e670e413c3080e6ad754eb3603d
https://doi.org/10.1016/0006-2952(96)00027-5
https://doi.org/10.1016/0006-2952(96)00027-5
Publikováno v:
Pharmacogenetics. 2:227-233
A test designed to estimate the extent and rate of formation of 7-hydroxycoumarin by measuring the urinary excretion of the metabolite in humans after administering 5 mg coumarin was developed. Coumarin was rapidly metabolized after oral administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93ace6eef4e3156c2a6c7df0d7d2bd8
https://doi.org/10.1097/00008571-199210000-00005
https://doi.org/10.1097/00008571-199210000-00005
Autor:
Riitta Heiskanen, Risto O. Juvonen, Matti A. Lang, Paavo Honkakoski, Anna-Liisa Rytkönen, Anneli Kojo
Publikováno v:
Biochemical Pharmacology. 42:1751-1759
Pyrazole and several of its derivatives increase the hepatic microsomal coumarin 7-hydroxylase to a variable extent. The strongest inducers are pyrazole itself and those derivatives which have a hydroxy group or a halogen at the 4-position of the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bde709bec0de4bba9ebcbdd1db199f
https://doi.org/10.1016/0006-2952(91)90512-4
https://doi.org/10.1016/0006-2952(91)90512-4
Publikováno v:
Archives of toxicology. 72(6)
Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4-hydroxypyrazole (4-OH) induce selectively the expression of CYP2A5 while expression of other CYPs is decreased. In this study we ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08094b43754a352fc346f756a972ec3a
https://pubmed.ncbi.nlm.nih.gov/9657280
https://pubmed.ncbi.nlm.nih.gov/9657280
Autor:
Anneli Kojo, H. Komulainen, Sirpa Pennanen, Risto O. Juvonen, Markku Pasanen, Jyrki Liesivuori
Publikováno v:
Humanexperimental toxicology. 15(5)
1 The metabolism of 2-ethylhexanoic acid (2-EHA) was studied in rat, mouse and human liver microsomes in vitro. The metabolites of 2-EHA were identified as methylated derivatives by gas chromatography-mass spectrometry.2 2-Ethyl-1,6-hexanedioic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa126b1af58c168b1add0f9c786cff6f
https://pubmed.ncbi.nlm.nih.gov/8735469
https://pubmed.ncbi.nlm.nih.gov/8735469
Publikováno v:
Hepatology (Baltimore, Md.). 23(3)
The effects of daily cocaine administration for up to 14 days were studied in terms of hepatic morphology and the expression of cytochrome P450 (CYP) enzymes in the mouse liver. Daily intraperitoneal doses of 60 mg/kg of cocaine for 3 days induced se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2d10d0818fd6cd50c1c296bbf8f984
https://pubmed.ncbi.nlm.nih.gov/8617431
https://pubmed.ncbi.nlm.nih.gov/8617431
Publikováno v:
Biochemical and biophysical research communications. 205(1)
Factors involved in CYP2A5 expression were studied in mouse liver primary hepatocytes in culture. CYP2A5-mediated coumarin 7-hydroxylase (COH) activity was retained in simple culture conditions for at least 96 hours and the activity was inducible up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50bbbe2755ee8fd3d68f8cdf2a0df0b6
https://pubmed.ncbi.nlm.nih.gov/7528014
https://pubmed.ncbi.nlm.nih.gov/7528014
The sex-dependent expression and inducibility of the cytochrome P450 2B subfamily was studied in DBA/2 and Balb/c mice, and their F1 recombinants, at the mRNA, protein and activity levels. Analysis of poly(A)+ RNA with specific oligonucleotide probes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe558b64b707a476f1db63b0722f404
https://europepmc.org/articles/PMC1132891/
https://europepmc.org/articles/PMC1132891/
Publikováno v:
Bulletin of environmental contamination and toxicology. 44(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2f616dcd32006b2bc477f931d50b23
https://pubmed.ncbi.nlm.nih.gov/2306537
https://pubmed.ncbi.nlm.nih.gov/2306537
Publikováno v:
Pharmacology & Toxicology. 65:104-109
Etomidate, metomidate and metyrapone, all potent inhibitors of steroid metabolizing monooxygenases, inhibit preferentially coumarin 7-hydroxylase (COH) amongst several liver microsomal monooxygenase activities from control and pyrazole-treated D2 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13be044a69ac5587f4f82fbc8267bab0
https://doi.org/10.1111/j.1600-0773.1989.tb01137.x
https://doi.org/10.1111/j.1600-0773.1989.tb01137.x