Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization

Autor: Mats Bemark, Helena Hazanov, Anneli Strömberg, Rathan Komban, Joel Holmqvist, Sofia Köster, Johan Mattsson, Per Sikora, Ramit Mehr, Nils Y. Lycke

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

The presence of long-lived memory IgA-producing B cells in the intestine has been difficult to document. Here the authors show that these cells can be induced by oral but not systemic immunization in mice, and characterize unique features that distin

Externí odkaz: https://doaj.org/article/3f378a82abe14213ae3c6b066e47eba1

Peyer's patch T

Autor: Inta, Gribonika, Anneli, Strömberg, Cristina, Lebrero-Fernandez, Karin, Schön, James, Moon, Mats, Bemark, Nils, Lycke

Publikováno v: Science immunology. 7(73)

T helper 17 (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae55605816843d17116e57f42a5963df
https://pubmed.ncbi.nlm.nih.gov/35776804

ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection

Autor: Mohammad Arabpour, Cristina Lebrero-Fernandez, Karin Schön, Anneli Strömberg, Vanja Börjesson, Katharina Lahl, Marlies Ballegeer, Xavier Saelens, Davide Angeletti, William Agace, Nils Lycke

Publikováno v: MUCOSAL IMMUNOLOGY
Arabpour, M, Lebrero-Fernandez, C, Schön, K, Strömberg, A, Börjesson, V, Lahl, K, Ballegeer, M, Saelens, X, Angeletti, D, Agace, W & Lycke, N 2022, ' ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection ', Mucosal Immunology, vol. 15, pp. 745-761 . https://doi.org/10.1038/s41385-022-00510-1

Migratory dendritic cells expressing CD103 are the targets for mucosal vaccines. These belong to either of two lineage-restricted subsets, cDC1 or cDC2 cells, which have been linked to priming of functionally distinct CD4 T cells. However, recent stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a136d9d22b39270548d7e25c49038fde
https://pubmed.ncbi.nlm.nih.gov/35418673

Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity

Autor: Ajibola Omokanye, Li Ching Ong, Cristina Lebrero-Fernandez, Valentina Bernasconi, Karin Schön, Anneli Strömberg, Mats Bemark, Xavier Saelens, Paulo Czarnewski, Nils Lycke

Publikováno v: MUCOSAL IMMUNOLOGY

The fate of tissue-resident memory CD4 T cells (Trm) has been incompletely investigated. Here we show that intranasal, but not parenteral, immunization with CTA1-3M2e-DD stimulated M2e-specific Th17 Trm cells, which conferred strong protection agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fbfb6ceb210cb0c22451f3c9a6a6cc
https://pubmed.ncbi.nlm.nih.gov/35260804

Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding V(H)81X-expressing B cells

Autor: Ola Grimsholm, Anneli Strömberg, Giljun Park, Ulf Yrlid, Weicheng Ren, Haixia Chen, Susanna Cardell, Dongfeng Chen, Nina Höök, Alessandra De Riva, Angelina I. Bernardi, Inga-Lill Mårtensson, Berglind Bergmann, Sofia Andersson, Alessandro Camponeschi, Inger Gjertsson

Publikováno v: Nature communications. 6

Random recombination of antibody heavy- and light-chain genes results in a diverse B-cell receptor (BCR) repertoire including self-reactive BCRs. However, tolerance mechanisms that prevent the development of self-reactive B cells remain incompletely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8118020d4ebf04479a11c74ee36d4892
https://pubmed.ncbi.nlm.nih.gov/25959489