Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anneke Kuipers"'
Publikováno v:
Biochemical Society Transactions
The conformation with which natural agonistic peptides interact with G protein-coupled receptor(s) (GPCR(s)) partly results from intramolecular interactions such as hydrogen bridges or is induced by ligand–receptor interactions. The conformational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc6e30310189b3917d5ea17221a57e8
https://hdl.handle.net/11370/a8315295-4393-43f0-acf4-80c4c8f0cfdd
https://hdl.handle.net/11370/a8315295-4393-43f0-acf4-80c4c8f0cfdd
Publikováno v:
Polymers, Vol 3, Iss 3, Pp 1282-1296 (2011)
The pentacyclic peptide antibiotic nisin, produced by Lactococcus lactis is ubiquitously applied as a food preservative. We previously demonstrated that the truncated nisin-(1-22) has only 10-fold lower activity than nisin. Here we aimed at further d
Externí odkaz:
https://doaj.org/article/d85a1d56cebc474294218e7f333fef8b
Autor:
Gert N. Moll, Erika Pétervári, Anneke Kuipers, Márta Balaskó, Andreas Koller, Susanne M. Brunner, Barbara Kofler
Publikováno v:
Neurotherapeutics
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18. SPRINGER
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18. SPRINGER
The regulatory (neuro)peptide galanin is widely distributed in the central and peripheral nervous systems, where it mediates its effects via three G protein-coupled receptors (GAL1-3R). Galanin has a vast diversity of biological functions, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9d2eab9d132670293aa1394d8bd9e7
https://pubmed.ncbi.nlm.nih.gov/34859381
https://pubmed.ncbi.nlm.nih.gov/34859381
Publikováno v:
Peptides, 112, 78-84. ELSEVIER SCIENCE INC
Native angiotensin-(1-7) exerts many therapeutic effects. However, it is rapidly degraded by ACE and other peptidases. This drawback is largely eliminated for lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), which is fully resistant to AC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc774fedfad62f7fcbe83b169aa85d31
https://doi.org/10.1016/j.peptides.2018.10.015
https://doi.org/10.1016/j.peptides.2018.10.015
Autor:
Matej Durik, Richard van Veghel, Anneke Kuipers, Rick Rink, Marijke Haas Jimoh Akanbi, Gert Moll, A. H. Jan Danser, Anton J. M. Roks
Publikováno v:
International Journal of Hypertension, Vol 2012 (2012)
Modulation of renin-angiotensin system (RAS) by angiotensin-(1–7) (Ang-(1–7)) is an attractive approach to combat the detrimental consequences of myocardial infarction (MI). However Ang-(1–7) has limited clinical potential due to its unfavorabl
Externí odkaz:
https://doaj.org/article/844ab8b1d4fe4269b705a5d6dac9631f
Publikováno v:
Peptides, 91, 33-39. ELSEVIER SCIENCE INC
Some modified glucagon-like-peptide-1 (GLP-1) analogs are highly important for treating type 2 diabetes. Here we investigated whether GLP-1 analogs expressed in Lactococcus lactis could be substrates for modification and export by the nisin dehydrata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf67fa2a075976c32214d7b925b4e417
https://research.rug.nl/en/publications/95957e01-7d28-45b4-80b9-5c5fbd518a9f
https://research.rug.nl/en/publications/95957e01-7d28-45b4-80b9-5c5fbd518a9f
Publikováno v:
Antonie Van Leeuwenhoek: International Journal of General and Molecular Microbiology, 110(3), 321-330. SPRINGER
The lantibiotic nisin is produced by Lactococcus lactis as a precursor peptide comprising a 23 amino acid leader peptide and a 34 amino acid post-translationally modifiable core peptide. We previously demonstrated that the conserved FNLD part of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e4af731c66ddcb34b5eee86cb8ee35
https://doi.org/10.1007/s10482-016-0802-6
https://doi.org/10.1007/s10482-016-0802-6
Publikováno v:
Peptides, 123:170193. ELSEVIER SCIENCE INC
Peptidase-resistant, lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), has shown therapeutic efficacy in animal models of cardiovascular, metabolic, kidney and pulmonary disease. Goal of the present study was testing the capacity of subcut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a97dcf01fe1d925624f382d82f2d59
https://doi.org/10.1016/j.peptides.2019.170193
https://doi.org/10.1016/j.peptides.2019.170193
Publikováno v:
Applied and Environmental Microbiology. 77:6794-6801
A major hurdle in the application of therapeutic peptides is their rapid degradation by peptidases. Thioether bridges effectively protect therapeutic peptides against breakdown, thereby strongly increasing bioavailability, enabling oral and pulmonary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1bbeeba25b3e446a6557bd8ef374a7
https://doi.org/10.1128/aem.05550-11
https://doi.org/10.1128/aem.05550-11
Publikováno v:
Applied and environmental microbiology, 74(21), 6591-6597. AMER SOC MICROBIOLOGY
The thioether rings in the lantibiotics lacticin 3147 and nisin are posttranslationally introduced by dehydration of serines and threonines, followed by coupling of these dehydrated residues to cysteines. The prepeptides of the two-component lantibio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f277c2d321499d44882c4ceecdaf46
https://research.rug.nl/en/publications/10e8ddfe-3cdb-4c9a-8d9f-458f09f00895
https://research.rug.nl/en/publications/10e8ddfe-3cdb-4c9a-8d9f-458f09f00895