DNA methylation-based classification of central nervous system tumours

Autor: Till Milde, Matija Snuderl, Martin Bendszus, Ralf Ketter, Catherine Keohane, Marco Prinz, Katja von Hoff, Aristotelis Tsirigos, Hildegard Dohmen, Manfred Westphal, Ute Pohl, Gabriele Schackert, Christian Koelsche, Eleonora Aronica, Bernhard Radlwimmer, Bjarne Winther Kristensen, Martin Hasselblatt, David T.W. Jones, Christian Mawrin, Dominik Sturm, Patricia Kohlhof, Peter Lichter, Annekathrin Kratz, Anne K. Braczynski, Helmut Mühleisen, Wolf Mueller, Wolfgang Brück, Stephan Frank, Andreas Unterberg, Michael Weller, Matthias A. Karajannis, Astrid Gnekow, Lukas Chavez, Andreas E. Kulozik, Christoph Geisenberger, Christine Haberler, Ori Staszewski, Amar Gajjar, Stephanie Rozsnoki, Mélanie Pagès, Olaf Witt, Paul A. Northcott, Matt Lechner, Thomas S. Jacques, Martina Deckert, Axel Benner, Jordan R. Hansford, Ingmar Blümcke, Marina Ryzhova, Gudrun Fleischhack, Jonathan Serrano, Jens Schittenhelm, Martin Sill, Sebastian Brandner, Stephan Tippelt, Dietmar R. Lohmann, Hermann L. Müller, Petra Temming, Nils W. Engel, Khalida Wani, Pablo Hernáiz Driever, Christel Herold-Mende, David W. Ellison, Arie Perry, Michael C. Frühwald, Stefan M. Pfister, Christof M. Kramm, Stefanie Brehmer, Daniel Hänggi, Jane Cryan, Torsten Pietsch, Wolfram Scheurlen, Marcel Seiz-Rosenhagen, Volkmar Hans, Adriana Olar, Werner Paulus, Chris Jones, Annie Huang, Patrick N. Harter, Felice Giangaspero, Marcel Kool, Kenneth Aldape, Marco Gessi, Silvia Hofer, Fausto J. Rodriguez, Anne Jouvet, Roland Coras, Annika K. Wefers, Leonille Schweizer, Vincent Peter Collins, Beatriz Lopes, Rolf Bjerkvig, Matthias Schick, Michel Mittelbronn, Andrey Korshunov, Johannes Schramm, Marc Zapatka, Annett Hölsken, Michael Platten, Kerstin Lindenberg, Jürgen Debus, Christian Hartmann, Ekkehard Hewer, Pascale Varlet, Melanie Bewerunge-Hudler, Till Acker, Matthias Preusser, Elisabeth J. Rushing, Michael A. Farrell, Kristian W. Pajtler, Nada Jabado, Kasthuri Kannan, Wolfgang Wick, David E. Reuss, Rolf Buslei, Nicholas G. Gottardo, Giles W. Robinson, Stefan Rutkowski, Jürgen Hench, Andreas von Deimling, Ulrich Schüller, Zane Jaunmuktane, Pieter Wesseling, Hendrik Witt, Albert J. Becker, Frank L. Heppner, Roger Fischer, Ziad Khatib, Guido Reifenberger, Arend Koch, Gabriele Calaminus, Karl H. Plate, Volker Hovestadt, Michael D. Taylor, Camelia-Maria Monoranu, Damian Stichel, Felix Sahm, Kristin Huang, David Capper, Florian Selt, Daniel Schrimpf, Rudi Beschorner, Boyan K. Garvalov

Publikováno v: Nature, 555(7697), 469-474. Nature Publishing Group
Nature, 555(7697), 469. Nature Publishing Group
Capper, D, Jones, D T W, Sill, M, Hovestadt, V, Schrimpf, D, Sturm, D, Koelsche, C, Sahm, F, Chavez, L, Reuss, D E, Kratz, A, Wefers, A K, Huang, K, Pajtler, K W, Schweizer, L, Stichel, D, Olar, A, Engel, N W, Lindenberg, K, Harter, P N, Braczynski, A K, Plate, K H, Dohmen, H, Garvalov, B K, Coras, R, Hölsken, A, Hewer, E, Bewerunge-Hudler, M, Schick, M, Fischer, R, Beschorner, R, Schittenhelm, J, Staszewski, O, Wani, K, Varlet, P, Pages, M, Temming, P, Lohmann, D, Selt, F, Witt, H, Milde, T, Witt, O, Aronica, E, Giangaspero, F, Rushing, E, Scheurlen, W, Geisenberger, C, Rodriguez, F J, Becker, A, Preusser, M, Haberler, C, Bjerkvig, R, Cryan, J, Farrell, M, Deckert, M, Hench, J R, Frank, S, Serrano, J, Kannan, K, Tsirigos, A, Brück, W, Hofer, S, Brehmer, S, Seiz-Rosenhagen, M, Hänggi, D, Hans, V, Rozsnoki, S, Hansford, J R, Kohlhof, P, Kristensen, B W, Lechner, M, Lopes, B, Mawrin, C, Ketter, R, Kulozik, A, Khatib, Z, Heppner, F, Koch, A, Jouvet, A, Keohane, C, Mühleisen, H, Mueller, W, Pohl, U, Prinz, M, Benner, A, Zapatka, M, Gottardo, N G, Driever, P H, Kramm, C M, Müller, H L, Rutkowski, S, von Hoff, K, Frühwald, M C, Gnekow, A, Fleischhack, G, Tippelt, S, Calaminus, G, Monoranu, C-M, Perry, A, Jones, C, Jacques, T S, Radlwimmer, B, Gessi, M, Pietsch, T, Schramm, J, Schackert, G, Westphal, M, Reifenberger, G, Wesseling, P, Weller, M, Collins, V P, Blümcke, I, Bendszus, M, Debus, J R, Huang, A, Jabado, N, Northcott, P A, Paulus, W, Gajjar, A, Robinson, G W, Taylor, M D, Jaunmuktane, Z, Ryzhova, M, Platten, M, Unterberg, A, Wick, W, Karajannis, M A, Mittelbronn, M, Acker, T, Hartmann, C, Aldape, K, Schüller, U, Buslei, R, Lichter, P, Kool, M, Herold-Mende, C, Ellison, D W, Hasselblatt, M, Snuderl, M, Brandner, S, Korshunov, A, von Deimling, A & Pfister, S M 2018, ' DNA methylation-based classification of central nervous system tumours ', Nature, vol. 555, no. 7697, pp. 469-474 . https://doi.org/10.1038/nature26000
Capper, D, Jones, D T W, Sill, M, Hovestadt, V, Schrimpf, D, Sturm, D, Koelsche, C, Sahm, F, Chavez, L, Reuss, D E, Kratz, A, Wefers, A K, Huang, K, Pajtler, K W, Schweizer, L, Stichel, D, Olar, A, Engel, N W, Lindenberg, K, Harter, P N, Braczynski, A K, Plate, K H, Dohmen, H, Garvalov, B K, Coras, R, Hölsken, A, Hewer, E, Bewerunge-Hudler, M, Schick, M, Fischer, R, Beschorner, R, Schittenhelm, J, Staszewski, O, Wani, K, Varlet, P, Pages, M, Temming, P, Lohmann, D, Selt, F, Witt, H, Milde, T, Witt, O, Aronica, E, Giangaspero, F, Rushing, E, Scheurlen, W, Geisenberger, C, Rodriguez, F J, Becker, A, Preusser, M, Haberler, C, Bjerkvig, R, Cryan, J, Farrell, M, Deckert, M, Hench, J, Frank, S, Serrano, J, Kannan, K, Tsirigos, A, Brück, W, Hofer, S, Brehmer, S, Seiz-Rosenhagen, M, Hänggi, D, Hans, V, Rozsnoki, S, Hansford, J R, Kohlhof, P, Kristensen, B W, Lechner, M, Lopes, B, Mawrin, C, Ketter, R, Kulozik, A, Khatib, Z, Heppner, F, Koch, A, Jouvet, A, Keohane, C, Mühleisen, H, Mueller, W, Pohl, U, Prinz, M, Benner, A, Zapatka, M, Gottardo, N G, Driever, P H, Kramm, C M, Müller, H L, Rutkowski, S, Von Hoff, K, Frühwald, M C, Gnekow, A, Fleischhack, G, Tippelt, S, Calaminus, G, Monoranu, C M, Perry, A, Jones, C, Jacques, T S, Radlwimmer, B, Gessi, M, Pietsch, T, Schramm, J, Schackert, G, Westphal, M, Reifenberger, G, Wesseling, P, Weller, M, Collins, V P, Blümcke, I, Bendszus, M, Debus, J, Huang, A, Jabado, N, Northcott, P A, Paulus, W, Gajjar, A, Robinson, G W, Taylor, M D, Jaunmuktane, Z, Ryzhova, M, Platten, M, Unterberg, A, Wick, W, Karajannis, M A, Mittelbronn, M, Acker, T, Hartmann, C, Aldape, K, Schüller, U, Buslei, R, Lichter, P, Kool, M, Herold-Mende, C, Ellison, D W, Hasselblatt, M, Snuderl, M, Brandner, S, Korshunov, A, Von Deimling, A & Pfister, S M 2018, ' DNA methylation-based classification of central nervous system tumours ', Nature, vol. 555, no. 7697, pp. 469-474 . https://doi.org/10.1038/nature26000

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5047d9e6db898ab95d5c17d081d6d9b6
https://doi.org/10.1038/nature26000

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

Autor: Marcel Seiz-Rosenhagen, Daniel Hänggi, Thomas Hielscher, Ralf Ketter, Jens Schittenhelm, Dominik Sturm, Manfred Westphal, Andreas Unterberg, Christel Herold-Mende, Michel Mittelbronn, Michael Weller, Stefan M. Pfister, Stefanie Brehmer, Peter Baumgarten, Martin Sill, Christian Koelsche, David T.W. Jones, Christian Mawrin, Matthias Simon, Lukas Chavez, Annekathrin Kratz, Anna S. Berghoff, Hans-Georg Wirsching, Sebastian Schefzyk, Matthias Schick, Annika K. Wefers, V. Peter Collins, Hayley P Ellis, Andreas von Deimling, Albert J. Becker, Kathreena M Kurian, Matthias Preusser, Damian Stichel, Felix Sahm, Michael Platten, Katharina Drueschler, Werner Paulus, Arend Koch, Ali Fuat Okuducu, Melanie Bewerunge-Hudler, Volker Hovestadt, Katrin Lamszus, Elisabeth J. Rushing, Kristin Huang, David Capper, Wolfgang Wick, David E. Reuss, Daniel Schrimpf, Christine Jungk, Konstantin Okonechnikov

Publikováno v: Sahm, F, Schrimpf, D, Stichel, D, Jones, D T W, Hielscher, T, Schefzyk, S, Okonechnikov, K, Koelsche, C, Reuss, D E, Capper, D, Sturm, D, Wirsching, H-G, Berghoff, A S, Baumgarten, P, Kratz, A, Huang, K, Wefers, A K, Hovestadt, V, Sill, M, Ellis, H P, Kurian, K M, Okuducu, A F, Jungk, C, Drueschler, K, Schick, M, Bewerunge-Hudler, M, Mawrin, C, Seiz-Rosenhagen, M, Ketter, R, Simon, M, Westphal, M, Lamszus, K, Becker, A, Koch, A, Schittenhelm, J, Rushing, E J, Collins, V P, Brehmer, S, Chavez, L, Platten, M, Hänggi, D, Unterberg, A, Paulus, W, Wick, W, Pfister, S M, Mittelbronn, M, Preusser, M, Herold-Mende, C, Weller, M & von Deimling, A 2017, ' DNA methylation-based classification and grading system for meningioma : a multicentre, retrospective analysis ', Lancet Oncology, vol. 18, no. 5, pp. 682-694 . https://doi.org/10.1016/S1470-2045(17)30155-9

Summary Background The WHO classification of brain tumours describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. Grading is based solely on histology, with an absence of mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a422031054c507cc2b39a2704fe6c5
https://doi.org/10.1016/s1470-2045(17)30155-9

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

Autor: Christel Herold-Mende, Marcel Seiz-Rosenhagen, Michel Mittelbronn, Stefan M. Pfister, Jana Reuss, Christian Koelsche, David Capper, Daniel Schrimpf, Joachim Weis, Volker Hovestadt, Arie Perry, Mirko Arp, David T.W. Jones, Annekathrin Kratz, Rezvan Ahmadi, Werner Paulus, Andreas von Deimling, Christian Mawrin, Albert J. Becker, Felix Sahm, Gunhild Mechtersheimer, Manuel Röhrich, Jens Schittenhelm, Daniel Hänggi, Christian Hartmann, Ali Fuat Okuducu, Melanie Bewerunge-Hudler, David E. Reuss, Andreas Unterberg, Victor F. Mautner, Stefanie Heim

Publikováno v: Acta Neuropathologica. 131:877-887

The vast majority of peripheral nerve sheath tumors derive from the Schwann cell lineage and comprise diverse histological entities ranging from benign schwannomas and neurofibromas to high-grade malignant peripheral nerve sheath tumors (MPNST), each

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a893fd6c0fe8a3917421f1880909821
https://doi.org/10.1007/s00401-016-1540-6

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

Autor: Damian Stichel, Matthias Schick, Daniel Schrimpf, Michel Mittelbronn, Andrey Korshunov, Felix Sahm, Andreas von Deimling, Kristin Huang, Annika K. Wefers, David Capper, Melanie Bewerunge-Hudler, Andreas Unterberg, David T.W. Jones, Astrid Jeibmann, Christel Herold-Mende, Christian Koelsche, Annekathrin Kratz, Daniel Hänggi, Michael Platten, Sebastian Brandner, Stefan M. Pfister, Wolfgang Wick, David E. Reuss

Publikováno v: Acta neuropathologica. 133(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f28abff1ba1e558659dc293aa53c5b
https://pubmed.ncbi.nlm.nih.gov/28000032

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

Autor: Olaf Witt, Ivo Buchhalter, Manuela Hummel, Andreas Unterberg, Andrey Korshunov, Wolfgang Wick, David E. Reuss, David T.W. Jones, Christian Mawrin, Andreas von Deimling, Antje Wick, David Capper, Marcel Kool, Benedikt Wiestler, Till Milde, Jochen Meyer, Daniel Schrimpf, Felix Sahm, Michael Platten, Florian Selt, Melanie Bewerunge-Hudler, Ulrich Schüller, Christine Jungk, Christian Koelsche, Annekathrin Kratz, Christel Herold-Mende, Stefan M. Pfister, Dominik Sturm

Publikováno v: Acta neuropathologica. 131(6)

With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of neuropathology samples has vastly increased. We therefore developed a customized enrichment/hybrid-captu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc437c072036612951241e86549709d
https://pubmed.ncbi.nlm.nih.gov/26671409