Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Annegret Reinhold"'
Autor:
Anna Krone, Yan Fu, Simon Schreiber, Johanna Kotrba, Loisa Borde, Aileen Nötzold, Christoph Thurm, Jonas Negele, Tobias Franz, Sabine Stegemann-Koniszewski, Jens Schreiber, Christoph Garbers, Aniruddh Shukla, Robert Geffers, Burkhart Schraven, Dirk Reinhold, Anne Dudeck, Annegret Reinhold, Andreas J. Müller, Sascha Kahlfuss
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract T helper (Th) cells provide immunity to pathogens but also contribute to detrimental immune responses during allergy and autoimmunity. Th2 cells mediate asthmatic airway inflammation and Th1 cells are involved in the pathogenesis of multiple
Externí odkaz:
https://doaj.org/article/627f9fcd527c42c48b282dfde8d57336
Autor:
Martha A. L. Böning, Gerald P. Parzmair, Andreas Jeron, Henning P. Düsedau, Olivia Kershaw, Baolin Xu, Borna Relja, Dirk Schlüter, Ildiko Rita Dunay, Annegret Reinhold, Burkhart Schraven, Dunja Bruder
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The adhesion and degranulation-promoting adaptor protein (ADAP) serves as a multifunctional scaffold and is involved in the formation of immune signaling complexes. To date, only limited data exist regarding the role of ADAP in pathogen-specific immu
Externí odkaz:
https://doaj.org/article/40b1283625f44707913cbe8ee3d0e7f2
Autor:
Nirdosh Dadwal, Charlie Mix, Annegret Reinhold, Amelie Witte, Christian Freund, Burkhart Schraven, Stefanie Kliche
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cells are the key players of the adaptive immune response. They coordinate the activation of other immune cells and kill malignant and virus-infected cells. For full activation T cells require at least two signals. Signal 1 is induced after recogni
Externí odkaz:
https://doaj.org/article/83cf366000cf4fc7b63668138c2eceab
Autor:
Linda Voss, Karina Guttek, Annika Reddig, Annegret Reinhold, Martin Voss, Burkhart Schraven, Dirk Reinhold
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Repositioning of approved drugs for identifying new therapeutic purposes is an alternative, time and cost saving strategy to classical drug development. Here, we screened a library of 786 FDA-approved drugs to find compounds, which can potentially be
Externí odkaz:
https://doaj.org/article/f578098549af40ed8ffe5244d2cdc5ed
Autor:
Martha A. L. Böning, Stephanie Trittel, Peggy Riese, Marco van Ham, Maxi Heyner, Martin Voss, Gerald P. Parzmair, Frank Klawonn, Andreas Jeron, Carlos A. Guzman, Lothar Jänsch, Burkhart Schraven, Annegret Reinhold, Dunja Bruder
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The adhesion and degranulation-promoting adaptor protein (ADAP) serves as a multifunctional scaffold and is involved in the formation of immune signaling complexes. To date only limited and moreover conflicting data exist regarding the role of ADAP i
Externí odkaz:
https://doaj.org/article/ce4e454661cc46a7be438dd5540edb06
Autor:
Christoph Thurm, Annegret Reinhold, Katrin Borucki, Sascha Kahlfuss, Eugen Feist, Jens Schreiber, Dirk Reinhold, Burkhart Schraven
Publikováno v:
Vaccines, Vol 10, Iss 2, p 333 (2022)
The COVID-19 pandemics has caused the death of almost six million people worldwide. In order to establish collective immunity, the first vaccines that were approved in Germany were the vector virus-based vaccine Vaxzevria and the mRNA vaccines Comirn
Externí odkaz:
https://doaj.org/article/4ef895997a664dca97ea090c4d0ffcdc
Autor:
Linda Voss, Karina Guttek, Annika Reddig, Annegret Reinhold, Martin Voss, Luca Simeoni, Burkhart Schraven, Dirk Reinhold
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 727 (2021)
Repositioning of approved drugs is an alternative time- and cost-saving strategy to classical drug development. Statins are 3-hydroxy-3-methylglutaryl-CoA (HMG CoA) reductase inhibitors that are usually used as cholesterol-lowering medication, and th
Externí odkaz:
https://doaj.org/article/55c0b311183b40f79609e06693d88f26
Autor:
Jochen Rudolph, Clara Meinke, Martin Voss, Karina Guttek, Stefanie Kliche, Dirk Reinhold, Burkhart Schraven, Annegret Reinhold
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, prolife
Externí odkaz:
https://doaj.org/article/e3ee162b42464e38b0b75270d83f82f3
Autor:
Natalie Waldt, Anke Seifert, Yunus Emre Demiray, Eric Devroe, Benjamin E. Turk, Peter Reichardt, Charlie Mix, Annegret Reinhold, Christian Freund, Andreas J. Müller, Burkhart Schraven, Oliver Stork, Stefanie Kliche
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The integrin LFA-1 (CD11a/CD18) plays a critical role in the interaction of T cells with antigen presenting cells (APCs) to promote lymphocyte differentiation and proliferation. This integrin can be present either in a closed or in an open active con
Externí odkaz:
https://doaj.org/article/96ff15d838594787915b399ed27376e1
Autor:
Dirk Reinhold, Karina Guttek, Annika Reddig, Linda Voss, Claudia Schubert, Sascha Kahlfuss, Kurt Grüngreiff, Burkhart Schraven, Annegret Reinhold
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 246 (2021)
T cell activation mediates immunity to pathogens. On the flipside, T cells are also involved in pathological immune responses during chronic autoimmune diseases. We recently reported that zinc aspartate, a registered drug with high bioavailability, d
Externí odkaz:
https://doaj.org/article/37ac9c30f77243cebc727c3be94d9967