Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Autor: André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon

Publikováno v: Biomolecules, Vol 10, Iss 6, p 858 (2020)

(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholineste

Externí odkaz: https://doaj.org/article/c8ad1bdb8ca0419e90bec0584f145514

Implication of glycogen synthase kinase 3 in diabetes-associated islet inflammation

Autor: Bernard Portha, Blandine Gausserès, Kamel Maouche, Jamileh Movassat, Mathieu Armanet, Anne-Sophie Hanak, Bruno Mégarbane, D. Bailbé, Junjun Liu, Gaëlle Pommier, Pierre Cattan, Etienne Delangre, Caterina Luana Pitasi

Publikováno v: Journal of Endocrinology
Journal of Endocrinology, 2020, 244 (1), pp.133-148. ⟨10.1530/JOE-19-0239⟩
Journal of Endocrinology, BioScientifica, 2020, 244 (1), pp.133-148. ⟨10.1530/JOE-19-0239⟩

Islet inflammation is associated with defective β cell function and mass in type 2 diabetes (T2D). Glycogen synthase kinase 3 (GSK3) has been identified as an important regulator of inflammation in different diseased conditions. However, the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353b4231ff7cfa548b271e52916745ee
https://doi.org/10.1530/joe-19-0239

Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern

Autor: Jean-Louis Laplanche, Lucie Chevillard, Rodolphe Lebeau, Nadia Benturquia, Anne-Sophie Hanak, Bruno Mégarbane, Patricia Risède

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2017, 76, pp.124-133. ⟨10.1016/j.pnpbp.2017.03.005⟩
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2017, 76, pp.124-133

International audience; Severity of lithium poisoning depends on the ingested dose, previous treatment duration and renal function. No animal study has investigated neurobehavioral differences in relation to the lithium poisoning pattern observed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8c6ad50f3bd24980a17a6f9d881227
https://hal-descartes.archives-ouvertes.fr/hal-01899918

Investigation of lithium distribution in the rat brain ex vivo using lithium-7 magnetic resonance spectroscopy and imaging at 17.2 T

Autor: Frank Bellivier, Patricia Risède, David André Barrière, Eric Giacomini, Fawzi Boumezbeur, Boucif Djemai, Joël Poupon, Anne-Sophie Hanak, Jacques Stout, Bruno Mégarbane, Lucie Chevillard

Publikováno v: NMR in Biomedicine
NMR in Biomedicine, 2017, 30 (11), pp.e3770. ⟨10.1002/nbm.3770⟩

International audience; Lithium is the first-line mood stabilizer for the treatment of patients with bipolar disorder. However, its mechanisms of action and transport across the blood–brain barrier remain poorly understood. The contribution of lith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d739577f3df7c5844ba75ceaa8dd9a53
https://doi.org/10.1002/nbm.3770