Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anne-Sophie Bessis"'
Autor:
Mark P. Epping-Jordan, Françoise Girard, Anne-Sophie Bessis, Vincent Mutel, Christelle Boléa, Francis Derouet, Abdelhak Bessif, Brice Mingard, Stéphanie Barbier, Justine S. Paradis, Jean-Philippe Rocher, Robert Lütjens, Mikhail Kalinichev, Sonia Poli
Publikováno v:
Cells, Vol 12, Iss 7, p 1004 (2023)
Parkinson’s disease (PD) patients suffer not only from the primary motor symptoms of the disease but also from a range of non-motor symptoms (NMS) that cause disability and low quality of life. Excessive glutamate activity in the basal ganglia resu
Externí odkaz:
https://doaj.org/article/ac27149e13ab4f06962a2c0891cfc4ae
Publikováno v:
Amino Acids. 24:303-310
Two glutamic acid analogs (1 SR,3 RS,4 RS)- and (1 SR,3 SR,4 SR)-1-amino-4-phosphono cyclopentane-1,3-dicarboxylic acids (APCPD) have been synthesized. Pure E-(diethoxy-phosphoryl)-acrylic acid ethyl ester was obtained from ethyl propiolate, phenol a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f57f71fb0865b2215dc92a9782fd69
https://doi.org/10.1007/s00726-002-0405-6
https://doi.org/10.1007/s00726-002-0405-6
Autor:
Anne-Sophie Bessis, Jean-Philippe Pin, Philippe Rondard, Isabelle Brabet, Francine Acher, Nicolas Triballeau, Laurent Prézeau, Florence Gaven
Publikováno v:
Proceedings of the National Academy of Sciences. 99:11097-11102
Ca 2+ , pheromones, sweet taste compounds, and the main neurotransmitters glutamate and γ-aminobutyric acid activate G protein-coupled receptors (GPCRs) that constitute the GPCR family 3. These receptors are dimers, and each subunit has a large extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c149a4da1d11fd405dcca7cd57c41edf
https://doi.org/10.1073/pnas.162138699
https://doi.org/10.1073/pnas.162138699
Publikováno v:
Journal of Medicinal Chemistry. 45:3171-3183
Several potent and group selective agonists of metabotropic glutamate receptors (mGluRs) have been docked at mGlu1,2,4R binding sites in the closed conformation of the bilobate extracellular domain. Quisqualic acid and (S)-3,5-dihydroxyphenylglycine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bde2bc71df790a806cbac3e6703b2a
https://doi.org/10.1021/jm010323l
https://doi.org/10.1021/jm010323l
Publikováno v:
European Journal of Pharmacology. 394:17-26
In the brain, group-III metabotropic glutamate (mGlu) receptors mGlu(4), mGlu(7) and mGlu(8) receptors play a critical role in controlling the release process at many glutamatergic synapses. The pharmacological profile of mGlu(4) receptor has been st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67d137b4cb0ac8421dc0ff44b838c0c
https://doi.org/10.1016/s0014-2999(00)00113-8
https://doi.org/10.1016/s0014-2999(00)00113-8
Publikováno v:
Neuropharmacology. 38:1543-1551
To get an insight into the bioactive conformation of glutamic acid and its topological environment at the mGluR4 binding site, a pharmacophore model was constructed using molecular modeling. Agonists of known activities were used to run the Apex-3D p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1b5b81025ae8e1d93449fefdb6765d
https://doi.org/10.1016/s0028-3908(99)00096-9
https://doi.org/10.1016/s0028-3908(99)00096-9
Publikováno v:
European Journal of Pharmacology. 375:277-294
The metabotropic glutamate receptors are GTP-binding-protein (G-protein) coupled receptors that play important roles in regulating the activity of many synapses in the central nervous system. As such, these receptors are involved in a wide number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95828f005ab5a3d30f5a84ae70441f69
https://doi.org/10.1016/s0014-2999(99)00258-7
https://doi.org/10.1016/s0014-2999(99)00258-7
Autor:
Jean-Philippe Pin, Anne-Sophie Bessis, Julie Kniazeff, Damien Maurel, Laurent Prézeau, Hervé Ansanay
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2004, 11 (8), pp.706-13. ⟨10.1038/nsmb794⟩
Nature Structural and Molecular Biology, Nature Publishing Group, 2004, 11 (8), pp.706-13. ⟨10.1038/nsmb794⟩
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein-coupled receptors such as metabotropic glutamate (mGlu) receptors that have large extracellular domains (ECDs) where agonists bind. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0563a4ad9593ba1666050e2f2c5f81
https://hal.archives-ouvertes.fr/hal-00318999/file/Kniazeff_NSMB_2004.pdf
https://hal.archives-ouvertes.fr/hal-00318999/file/Kniazeff_NSMB_2004.pdf
Autor:
Jean-Philippe Pin, Agnès Hémar, Lawrence Fourgeaud, Jean-Christophe Olivo-Marin, Anne-Sophie Bessis, Françoise Rossignol
Publikováno v:
The Journal of biological chemistry. 278(14)
Metabotropic glutamate receptors 5 (mGluR5) are members of the growing group C G protein-coupled receptor family. Widely expressed in mammalian brain, they are involved in modulation of the glutamate transmission. By means of transfection of mGluR5 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def3c816cc4327f3cd9bd819c927c449
https://pubmed.ncbi.nlm.nih.gov/12529370
https://pubmed.ncbi.nlm.nih.gov/12529370
Autor:
Michèle Sebben, Robin D. Clark, Aline Dumuis, Joël Bockaert, Sylvie Claeysen, Renee Sharon Martin, Anne-Sophie Bessis, Lara Joubert
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2002, 277 (28), pp.25502-25511. ⟨10.1074/jbc.M202539200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2002, 277 (28), pp.25502-25511. ⟨10.1074/jbc.M202539200⟩
International audience; Activation of G protein-coupled receptors is thought to involve disruption of intramolecular interactions that stabilize their inactive conformation. Such disruptions are induced by agonists or by constitutively active mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89a9f7875da095b4cd11c0b71c7aaa7
https://hal.archives-ouvertes.fr/hal-02486579/document
https://hal.archives-ouvertes.fr/hal-02486579/document