Perturbations of NAD+salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

Autor: Steve Risis, Jonas T. Treebak, Benjamin A. H. Jensen, Julie Goldenbaum, Astrid L. Basse, Morten Dall, Marianne Agerholm, Søren Nørvang Madsen, Bjørn Quistorff, Sara G. Vienberg, Clara Prats, Steen Larsen, Anne-Sofie Graae

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 314:E377-E395

Nicotinamide adenine dinucleotide (NAD+) can be synthesized by nicotinamide phosphoribosyltransferase (NAMPT). We aimed to determine the role of NAMPT in maintaining NAD+levels, mitochondrial function, and metabolic homeostasis in skeletal muscle cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3258ed031a1c8860b877ca71ed0a85f8
https://doi.org/10.1152/ajpendo.00213.2017

ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations

Autor: Suneel S. Apte, Birgitte Holst, Marie Balslev Backe, Jesper B. Birk, Annette K. Serup, Steen Larsen, Linn Gillberg, Björn Zethelius, Niels Wellner, Karolina Sulek, Jonas T. Treebak, Allan Vaag, Sara H Lystbæk, Anders Nykjaer, Hans-Ulrich Häring, Rasmus Ribel-Madsen, Trine Welløv Boesgaard, Jørgen F. P. Wojtaszewski, Niels Grarup, Johanne Dubail, Sabina Chubanava, Mads Kjolby, Harald Staiger, Clara Prats, Anne-Sofie Graae, Andreas Fritsche, Sara G. Vienberg, Torben Hansen, Bente Kiens, Oluf Pedersen

Publikováno v: Diabetes 68, 502-514 (2019)
Graae, A-S, Grarup, N, Ribel-Madsen, R, Lystbæk, S H, Boesgaard, T, Staiger, H, Fritsche, A, Wellner, N, Sulek, K, Kjolby, M, Backe, M B, Chubanava, S, Prats, C, Serup, A K, Birk, J B, Dubail, J, Gillberg, L, Vienberg, S G, Nykjær, A, Kiens, B, Wojtaszewski, J F P, Larsen, S, Apte, S S, Häring, H-U, Vaag, A, Zethelius, B, Pedersen, O, Treebak, J T, Hansen, T & Holst, B 2019, ' ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations ', Diabetes, vol. 68, no. 3, pp. 502-514 . https://doi.org/10.2337/db18-0418
Diabetes
Graae, A S, Grarup, N, Ribel-Madsen, R, Lystbæk, S H, Boesgaard, T, Staiger, H, Fritsche, A, Wellner, N, Sulek, K, Kjolby, M, Backe, M B, Chubanava, S, Prats, C, Serup, A K, Birk, J B, Dubail, J, Gillberg, L, Vienberg, S G, Nykjær, A, Kiens, B, Wojtaszewski, J F P, Larsen, S, Apte, S S, Häring, H U, Vaag, A, Zethelius, B, Pedersen, O, Treebak, J T, Hansen, T & Holst, B 2019, ' ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations ' Diabetes, vol. 68, no. 3, pp. 502-514 . https://doi.org/10.2337/db18-0418

The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity. We show that the variant is associated with increased expression of the secreted ADAMTS9 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1222d05d40196cc2a07501a33f4eb3
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55586

Model-Based Discovery of Synthetic Agonists for the Zn

Autor: Thomas M, Frimurer, Franziska, Mende, Anne-Sofie, Graae, Maja S, Engelstoft, Kristoffer L, Egerod, Rie, Nygaard, Lars-Ole, Gerlach, Jakob Bondo, Hansen, Thue W, Schwartz, Birgitte, Holst

Publikováno v: Journal of medicinal chemistry. 60(3)

The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6219f4445c8519f5fb32f478c8f98cc0
https://pubmed.ncbi.nlm.nih.gov/28045522