Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Anne-Ruxandra Carvunis"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background Recent studies uncovered pervasive transcription and translation of thousands of noncanonical open reading frames (nORFs) outside of annotated genes. The contribution of nORFs to cellular phenotypes is difficult to infer using con
Externí odkaz:
https://doaj.org/article/996692ad847c4672a973fd299295c343
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102826- (2024)
Summary: Ribosome profiling is a sequencing technique that provides a global picture of translation across a genome. Here, we present iRibo, a software program for integrating any number of ribosome profiling samples to obtain sensitive inference of
Externí odkaz:
https://doaj.org/article/4e73c37c392547a68ea04100fc3609ea
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002409 (2023)
Ribosome profiling experiments indicate pervasive translation of short open reading frames (ORFs) outside of annotated protein-coding genes. However, shotgun mass spectrometry (MS) experiments typically detect only a small fraction of the predicted p
Externí odkaz:
https://doaj.org/article/19b2922268d14d898f71a10e7e1e5803
Autor:
Aude Guénolé, Fabien Velilla, Aymeric Chartier, April Rich, Anne-Ruxandra Carvunis, Claude Sardet, Martine Simonelig, Bijan Sobhian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization. Here, we show that the RING finger protein RNF219 co-purifies with the CCR4-NOT complex
Externí odkaz:
https://doaj.org/article/3427ae9a9fe045749d317c81f21264e1
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010181 (2022)
The high-level organization of the cell is embedded in indirect relationships that connect distinct cellular processes. Existing computational approaches for detecting indirect relationships between genes typically consist of propagating abstract inf
Externí odkaz:
https://doaj.org/article/e6ef775ed58441d09c5fe111c03f1a9d
Autor:
Nikolaos Vakirlis, Omer Acar, Brian Hsu, Nelson Castilho Coelho, S. Branden Van Oss, Aaron Wacholder, Kate Medetgul-Ernar, Ray W. Bowman, Cameron P. Hines, John Iannotta, Saurin Bipin Parikh, Aoife McLysaght, Carlos J. Camacho, Allyson F. O’Donnell, Trey Ideker, Anne-Ruxandra Carvunis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
There is increasing evidence that protein-coding genes can emerge de novo from noncoding genomic regions. Vakirlis et al. propose that sequences encoding transmembrane polypeptides can emerge de novo in thymine-rich genomic regions and provide organi
Externí odkaz:
https://doaj.org/article/faf179aee3974a3a939a01b1132508f8
Publikováno v:
eLife, Vol 9 (2020)
The origin of ‘orphan’ genes, species-specific sequences that lack detectable homologues, has remained mysterious since the dawn of the genomic era. There are two dominant explanations for orphan genes: complete sequence divergence from ancestral
Externí odkaz:
https://doaj.org/article/4c9c838d6281407b84e016403f3a042f
Publikováno v:
eLife, Vol 8 (2019)
The word function has many different meanings in molecular biology. Here we explore the use of this word (and derivatives like functional) in research papers about de novo gene birth. Based on an analysis of 20 abstracts we propose a simple lexicon t
Externí odkaz:
https://doaj.org/article/67efa874b3034aeda3fd517eb32d44c8
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008160 (2019)
Externí odkaz:
https://doaj.org/article/b30754a7ad5a40a69188112875f89168
Autor:
Nikolaos Vakirlis, Omer Acar, Brian Hsu, Nelson Castilho Coelho, S. Branden Van Oss, Aaron Wacholder, Kate Medetgul-Ernar, Ray W. Bowman, Cameron P. Hines, John Iannotta, Saurin Bipin Parikh, Aoife McLysaght, Carlos J. Camacho, Allyson F. O’Donnell, Trey Ideker, Anne-Ruxandra Carvunis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20609-y.
Externí odkaz:
https://doaj.org/article/5b04002d1b06458bb822acc60c420688