Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue.

Autor: Jakob Hedegaard, Kasper Thorsen, Mette Katrine Lund, Anne-Mette K Hein, Stephen Jacques Hamilton-Dutoit, Søren Vang, Iver Nordentoft, Karin Birkenkamp-Demtröder, Mogens Kruhøffer, Henrik Hager, Bjarne Knudsen, Claus Lindbjerg Andersen, Karina Dalsgaard Sørensen, Jakob Skou Pedersen, Torben Falck Ørntoft, Lars Dyrskjøt

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e98187 (2014)

Formalin-fixed, paraffin-embedded (FFPE) tissues are an invaluable resource for clinical research. However, nucleic acids extracted from FFPE tissues are fragmented and chemically modified making them challenging to use in molecular studies. We analy

Externí odkaz: https://doaj.org/article/41d99fce8e504708bd2925e3502cfe16

Supplementary Table 2 from Gene Expression Signatures Predict Outcome in Non–Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Autor: Torben F. Ørntoft, Niels Marcussen, Klaus M.E. Jensen, Jens L. Jensen, Anne-Mette K. Hein, François Radvanyi, Aurélie Caillault, Dimitri Vordos, Yves Allory, Kenneth Wester, Manuel de la Torre, Per-Uno Malmström, Margaret Knowles, Sanjeev Kotwal, Carolyn Hurst, Alfredo Carrato, Núria Malats, Francisco X. Real, Karsten Zieger, Lars Dyrskjøt

Supplementary Table 2 from Gene Expression Signatures Predict Outcome in Non–Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22424d952e1a90a02117a616171302fb
https://doi.org/10.1158/1078-0432.22439781.v1

Supplementary Table 1 from Gene Expression Signatures Predict Outcome in Non–Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Autor: Torben F. Ørntoft, Niels Marcussen, Klaus M.E. Jensen, Jens L. Jensen, Anne-Mette K. Hein, François Radvanyi, Aurélie Caillault, Dimitri Vordos, Yves Allory, Kenneth Wester, Manuel de la Torre, Per-Uno Malmström, Margaret Knowles, Sanjeev Kotwal, Carolyn Hurst, Alfredo Carrato, Núria Malats, Francisco X. Real, Karsten Zieger, Lars Dyrskjøt

Supplementary Table 1 from Gene Expression Signatures Predict Outcome in Non–Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b157eb553b0284f6e176005a2159b8
https://doi.org/10.1158/1078-0432.22439784

Gene Expression Signatures Predict Outcome in Non–Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Autor: Margaret A. Knowles, Núria Malats, Niels Marcussen, Jens Ledet Jensen, François Radvanyi, Alfredo Carrato, Lars Dyrskjøt, Yves Allory, Torben F. Ørntoft, Karsten Zieger, Anne-Mette K. Hein, Aurélie Caillault, Kenneth Wester, Klaus Møller-Ernst Jensen, Sanjeev Kotwal, Manuel de la Torre, Francisco X. Real, Carolyn D. Hurst, Per-Uno Malmström, Dimitri Vordos

Publikováno v: Dyrskjøt, L, Zieger, K, Real, F X, Malats, N, Carrato, A, Hurst, C, Kotwal, S, Knowles, M, Malmström, P-U, de la Torre, M, Wester, K, Allory, Y, Vordos, D, Caillault, A, Radvanyi, F, Hein, A-M K, Jensen, J L, Jensen, K M E, Marcussen, N & Orntoft, T F 2007, ' Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma : a multicenter validation study ', Clinical Cancer Research, vol. 13, no. 12, pp. 3545-3551 . https://doi.org/10.1158/1078-0432.CCR-06-2940
Andersen, L D, Zieger, K, Real, F X, Malats, N, Carrato, A, Hurst, C, Kotwal, S, Knowles, M, Malmstrom, P-U, de la Torre, M, Wester, K, Allory, Y, Vordos, D, Caillault, A, Radvanyi, F, Hein, A-M K, Jensen, J L, Jensen, K M-E, Marcussen, N & Ørntoft, T F 2007, ' Gene expression signatures predict outcome in non-muscle invasive bladder carcinoma-a multi-center validation study ', Clinical Cancer Research, vol. 13, no. 12, pp. 3545-51 . https://doi.org/10.1158/1078-0432.CCR-06-2940

Purpose: Clinically useful molecular markers predicting the clinical course of patients diagnosed with non–muscle-invasive bladder cancer are needed to improve treatment outcome. Here, we validated four previously reported gene expression signature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6727ae5b3e4ebeaa14f0c88bbd842448
https://doi.org/10.1158/1078-0432.ccr-06-2940

Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis

Autor: Søren Brunak, Anne Sofie Brems-Eskildsen, Lars Dyrskjøt, Karina Dalsgaard Sørensen, Søren Laurberg, Michael Borre, Charlotte Modin, Torben F. Ørntoft, Claus L. Andersen, Mette Gaustadnes, Kai Wang, Kasper Thorsen, Mogens Kruhøffer, Anne-Mette K. Hein, Niels Tørring, Adrian R. Krainer

Publikováno v: Thorsen, K, Sørensen, K D, Brems-Eskildsen, A S, Modin, C, Gaustadnes, M, Hein, A-M K, Kruhøffer, M, Laurberg, S, Borre, M, Wang, K, Brunak, S, Krainer, A R, Tørring, N, Dyrskjøt, L, Andersen, C L & Ørntoft, T F 2008, ' Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis ', Molecular and Cellular Proteomics, vol. 7, no. 7, pp. 1214-24 . https://doi.org/10.1074/mcp.M700590-MCP200

Udgivelsesdato: 2008-Jul Alternative splicing enhances proteome diversity and modulates cancer-associated proteins. To identify tissue- and tumor-specific alternative splicing, we used the GeneChip Human Exon 1.0 ST Array to measure whole-genome exon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd868bfa0b3e002dc764609379f642b
https://pubmed.ncbi.nlm.nih.gov/18353764