Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy

Autor: Kazuhiko Nozaki, Fumio Suzuki, Antoine Depaulis, Ayako Shima, Naoki Nitta, Anne-Marie Laharie

Publikováno v: The European journal of neuroscience. 41(7)

Recent studies in animal models have suggested that the mammalian target of rapamycin (mTOR) signaling pathway is involved in several features of mesio-temporal lobe epilepsy (MTLE), and that its inhibition could have therapeutic interests. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24e8a88bae79d36b89780edba19cf47
https://pubmed.ncbi.nlm.nih.gov/25605420

A two-step culture method starting with early growth factors permits enhanced production of functional dendritic cells from murine splenocytes

Autor: Anne Marie Laharie, Patrice N. Marche, Rolande Berthier, Catherine Martinon-Ego

Publikováno v: Journal of Immunological Methods. 239:95-107

Dendritic cells (DC) are professional antigen presenting cells (APC) able to activate naive T cells and initiate the immune response. They are present in most tissues at very low concentrations and are difficult to isolate. DC can be obtained in larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fccaf69b603d0fb4323536fd45c772b
https://doi.org/10.1016/s0022-1759(00)00186-1

C3b complexation diversifies naturally processed T cell epitopes

Autor: Patrice N. Marche, Anne-Marie Laharie, Françoise M. Gabert, François Cretin, Marie-Bernadette Villiers, Vincent A. Serra

Publikováno v: Molecular Immunology
Molecular Immunology, Elsevier, 2007, 44 (11), pp.2893-2899. ⟨10.1016/j.molimm.2007.01.013⟩
Molecular Immunology, 2007, 44 (11), pp.2893-2899. ⟨10.1016/j.molimm.2007.01.013⟩

International audience; In addition to its well-established role in innate immunity, the complement component C3 is of critical importance in modulating the humoral response. In this study, we examined the effect of C3b linkage to tetanus toxin (TeNT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5d3ad0631743fa8810fa18e5911cd5
https://pubmed.ncbi.nlm.nih.gov/17320958

Amplification of the antibody response by C3b complexed to antigen through an ester link

Autor: Marie-Bernadette Villiers, Anne-Marie Laharie, Patrice N. Marche, Christian L. Villiers

Publikováno v: Molecular Immunology. 35:407

Complement C3 has been described as playing an important role in the cell-mediated immune response. C3b has the capacity to covalently bind Ag and then to stimulate in vitro Ag presentation to T lymphocytes. To verify this observation in vivo, we pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfeaaaa1027215547b708cbe96291f80
https://doi.org/10.1016/s0161-5890(98)90840-9