Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Anne-Marie L. Hogan"'
Autor:
Brandon I. Morinaka, Anne-Marie L. Hogan, Zhuqing Liu, Tadeusz F. Molinski, Regina M. Meis, Amos B. Smith, Thomas M. Razler
Publikováno v:
Tetrahedron. 67:5069-5078
The design, synthesis and biological evaluation of a new phorboxazole analogue, comprising an acetal replacement for the C-ring tetrahdropyran of the natural product and carrying a potency-enhancing C(45-46) vinyl chloride side chain, is described. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346717740f3d9981d6ed3f3cf1322f32
https://doi.org/10.1016/j.tet.2010.12.043
https://doi.org/10.1016/j.tet.2010.12.043
Autor:
Amos B. Smith, Michael J. James, Justin S. Potuzak, Virginia M.-Y. Lee, Yuemang Yao, Anne-Marie L. Hogan, Nuria Ibarz Ferrer, Kurt R. Brunden, Carlo Ballatore, John Q. Trojanowski
Publikováno v:
Pharmacological Research. 63:341-351
Tau, a protein that is enriched in neurons of the central nervous system (CNS), is thought to play a critical role in the stabilization of microtubules (MTs). Several neurodegenerative disorders referred to as tauopathies, including Alzheimer's disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3ec88c5beb70ea0a305ac8415ae6bc
https://doi.org/10.1016/j.phrs.2010.12.002
https://doi.org/10.1016/j.phrs.2010.12.002
Autor:
Donal F. O'Shea, Carsten Strohmann, Viktoria H. Gessner, Stephan G. Koller, Anne-Marie L. Hogan
Publikováno v:
Chemistry - A European Journal. 17:2996-3004
This article addresses the mechanistic features of asymmetric car- bolithiation of b-methylstyrenes. While often the presence of functional groups is required to obtain high enantioselec- tivities in carbolithiation reactions, simple b-methylstyrene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33583757a26bea1c3044c57af2d58e64
https://doi.org/10.1002/chem.201000814
https://doi.org/10.1002/chem.201000814
Autor:
Sharon X. Xie, Amos B. Smith, Virginia M.-Y. Lee, Carlo Ballatore, Justin S. Potuzak, Michiyo Iba, Yuemang Yao, Michael J. James, John Q. Trojanowski, Bin Zhang, Anne-Marie L. Hogan, Jenna C. Carroll, Kurt R. Brunden
Publikováno v:
The Journal of Neuroscience. 30:13861-13866
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs), and tau misfolding could l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af62b622af867c277f9dfffe5f20e43
https://doi.org/10.1523/jneurosci.3059-10.2010
https://doi.org/10.1523/jneurosci.3059-10.2010
Publikováno v:
Organic Letters. 9:1493-1496
[reaction: see text] The vinyl deprotonation of cis-stilbene can be readily achieved using s-BuLi in THF at -25 degrees C. The generated 1-lithio-1,2-diphenylethene undergoes an in situ Z-to-E isomerization, and subsequent reaction with electrophiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8175f4d2cee0fff3beba4b66ad8904b5
https://doi.org/10.1021/ol070239l
https://doi.org/10.1021/ol070239l
Autor:
Amos B. Smith, Virginia M.-Y. Lee, Jenna C. Carroll, Kurt R. Brunden, Yuemang Yao, Michiyo Iba, Justin S. Potuzak, Bin Zhang, Anne-Marie L. Hogan, John Q. Trojanowski, Sharon X. Xie, Carlo Ballatore
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(11)
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased phosphorylation and decreased solubility has been proposed to diminish normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf12f38244786670374fb2e1bab68cc9
https://pubmed.ncbi.nlm.nih.gov/22423084
https://pubmed.ncbi.nlm.nih.gov/22423084
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4ba13a9d9d88f0f85a624e5360bb26
https://doi.org/10.1002/chin.201003209
https://doi.org/10.1002/chin.201003209
A synthesis providing totally synthetic (+)-hemi-phorboxazole A (1), proceeding in two steps (85% yield) from known vinyl iodide precursor (+)-2, has been achieved in conjunction with the design, synthesis, and biological evaluation of two hemi-phorb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56d2282c92aaf1a9bd7036c86e1fcfe
https://europepmc.org/articles/PMC2743491/
https://europepmc.org/articles/PMC2743491/
Autor:
Anne-Marie L. Hogan, Thomas Tricotet, Carsten Strohmann, Donal F. O'Shea, Viktoria H. Gessner, Juliet Cotter, Patricia Fleming
Publikováno v:
ChemInform. 40
A stereochemistry-controlled suppression of carbolithiation facilitated a regioselective vinyl C−H lithiation of cis-stilbenes allowing routine regio- and stereoselective access to polysubstituted alkenes and heterocycles. This unique selectivity w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28de38ebde777716c1ebb6b4b7e56e03
https://doi.org/10.1002/chin.200928079
https://doi.org/10.1002/chin.200928079
Autor:
Anne-Marie L. Hogan, Douglas S. Auld, Donna M. Huryn, James Inglese, Kurt R. Brunden, Jennifer Wichterman, Alex Crowe, John Q. Trojanowski, Christopher P. Austin, Wenwei Huang, Carlo Ballatore, Virginia M.-Y. Lee, Amos B. Smith, Ruili Huang, Ronald L. Johnson, Joshua G. McCoy
Publikováno v:
Biochemistry. 48(32)
Inclusions comprised of fibrils of the microtubule- (MT-) associated protein tau are found in the brains of those with Alzheimer's disease (AD) and other neurodegenerative tauopathies. The pathology that is observed in these diseases is believed to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7051915a3714dfa7ba189711d99c9bc
https://pubmed.ncbi.nlm.nih.gov/19580328
https://pubmed.ncbi.nlm.nih.gov/19580328