Neuronal Sprouting and Reorganization in Bone Tissue Infiltrated by Human Breast Cancer Cells

Autor: Rie B. Hansen, Manasi Sayilekshmy, Michala S. Sørensen, Astrid H. Jørgensen, Ida B. Kanneworff, Emma K. E. Bengtsson, Tomas A. Grum-Schwensen, Michael M. Petersen, Charlotte Ejersted, Thomas L. Andersen, Christina M. Andreasen, Anne-Marie Heegaard

Publikováno v: Frontiers in Pain Research, Vol 3 (2022)

BackgroundPain is a common complication for patients with metastatic bone disease. Animal models suggest that the pain, in part, is driven by pathological sprouting and reorganization of the nerve fibers innervating the bone. Here, we investigate how

Externí odkaz: https://doaj.org/article/3daa2bba3d29446e90bd638e9c85eba0

Differential Pain‐Related Behaviors and Bone Disease in Immunocompetent Mouse Models of Myeloma

Autor: Marta Diaz‐delCastillo, Danna Kamstrup, Rikke Brix Olsen, Rie Bager Hansen, Thomas Pembridge, Brigita Simanskaite, Juan Miguel Jimenez‐Andrade, Michelle A Lawson, Anne‐Marie Heegaard

Publikováno v: JBMR Plus, Vol 4, Iss 2, Pp n/a-n/a (2020)

ABSTRACT Bone pain is a serious and debilitating symptom of multiple myeloma (MM) that impairs the quality of life of patients. The underlying mechanisms of the pain are unknown and understudied, and there is a need for immunocompetent preclinical mo

Externí odkaz: https://doaj.org/article/ee1179f5c8414121bb0c06b9c8892e8d

Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms

Autor: Michael S. Minett, Sarah Falk, Sonia Santana-Varela, Yury D. Bogdanov, Mohammed A. Nassar, Anne-Marie Heegaard, John N. Wood

Publikováno v: Cell Reports, Vol 6, Iss 2, Pp 301-312 (2014)

Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain. Constriction-injury-depe

Externí odkaz: https://doaj.org/article/7573c1aad53d411887931726ea7c84fb

Effect of sex in the MRMT-1 model of cancer-induced bone pain [version 3; referees: 2 approved]

Autor: Sarah Falk, Tamara Al-Dihaissy, Laura Mezzanotte, Anne-Marie Heegaard

Publikováno v: F1000Research, Vol 4 (2015)

An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to mo

Externí odkaz: https://doaj.org/article/d9dff7cb3d244071905bf870b703cd28

Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain

Autor: Xue Ying Zhang, Ahmed Barakat, Marta Diaz-delCastillo, Jan Vollert, Emily S. Sena, Anne-Marie Heegaard, Andrew S.C. Rice, Nadia Soliman

Publikováno v: Zhang, X Y, Barakat, A, Diaz-delcastillo, M, Vollert, J, Sena, E S, Heegaard, A, Rice, A S C & Soliman, N 2022, ' A systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease associated persistent pain ', Pain, vol. Publish Ahead of Print . https://doi.org/10.1097/j.pain.0000000000002632
Zhang, X Y, Barakat, A, Diaz-delCastillo, M, Vollert, J, Sena, E S, Heegaard, A-M, Rice, A S C & Soliman, N 2022, ' Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain ', Pain, vol. 163, no. 11, pp. 2076-2102 . https://doi.org/10.1097/j.pain.0000000000002632
Pain

Burrowing behaviour is used to assess pain-associated behaviour in laboratory rodents. To gain insight into how models of disease-associated persistent pain and analgesics affect burrowing behaviour, we performed a systematic review and meta-analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629908682a15a764a7b7150e11402dc7
https://doi.org/10.1097/j.pain.0000000000002632