MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression

Autor: Alix Bruneau, Jean-Louis Delaunay, Anne-Marie Durand-Schneider, Virginie Vauthier, Amel Ben Saad, Lynda Aoudjehane, Haquima El Mourabit, Romain Morichon, Thomas Falguières, Jérémie Gautheron, Chantal Housset, Tounsia Aït-Slimane

Publikováno v: Cells, Vol 11, Iss 4, p 617 (2022)

ABCB4, is an adenosine triphosphate-binding cassette (ABC) transporter localized at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine secretion into bile. Gene variations of ABCB4 cause different types of liver diseases,

Externí odkaz: https://doaj.org/article/1d4ade379e9b40148174424e5d1942ed

Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants

Autor: Ágota Tóth, Emmanuel Jacquemin, Isabelle Garcin, Jean-Louis Delaunay, Chantal Housset, Florent Di Meo, Angelika Janaszkiewicz, Alix Bruneau, Thomas Falguières, Martine Lapalus, Anne-Marie Durand-Schneider, Tounsia Aït-Slimane, Elodie Mareux, Emmanuel Gonzales, Virginie Vauthier, Amel Ben Saad

Publikováno v: Liver International
Liver International, Wiley-Blackwell, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩
Liver International, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩

International audience; Background & aim: ABCB4 is expressed at the canalicular membrane of hepatocytes. This ATP-binding cassette (ABC) transporter is responsible for the secretion of phosphatidylcholine into bile canaliculi. Missense genetic variat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1d478a09ed70ab74550169e6e80f1e
https://hal.sorbonne-universite.fr/hal-03263358/document

Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770)

Autor: Jean-Louis Delaunay, Isabelle Callebaut, Tounsia Aït-Slimane, Alix Bruneau, Chantal Housset, Brice Hoffmann, Emmanuel Jacquemin, Anne-Marie Durand-Schneider, Michèle Maurice, Véronique Barbu

Publikováno v: Hepatology (Baltimore, Md.). 65(2)

ABCB4 (MDR3) is an ATP-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes where it mediates phosphatidylcholine (PC) secretion. Variations in the ABCB4 gene are responsible for several biliary diseases, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84969824d554eee38fa024e7ee40ada2
https://pubmed.ncbi.nlm.nih.gov/28012258

A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature

Autor: Danièle Delautier, Emmanuel Jacquemin, Jean-Louis Delaunay, Alegna Rada, Michèle Maurice, Anne-Marie Durand-Schneider, Julien Gautherot, Tounsia Aït-Slimane

Publikováno v: Hepatology. 49:1218-1227

Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare liver disease characterized by early onset of cholestasis that leads to cirrhosis and liver failure before adulthood. PFIC3 may be improved by chronic administration of ursodeoxyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a8304a155b721bd4558c7708627f37
https://doi.org/10.1002/hep.22775

The Secreted Form of Dengue Virus Nonstructural Protein NS1 Is Endocytosed by Hepatocytes and Accumulates in Late Endosomes: Implications for Viral Infectivity

Autor: Marie-Thérèse Drouet, Michel Arborio, Michèle Maurice, Marie-Pascale Frenkiel, Jean Gruenberg, Anne-Marie Durand-Schneider, Marie Flamand, Isabelle Le Blanc, Sophie Alcon-LePoder, Pascal Roux

Publikováno v: Journal of Virology. 79:11403-11411

The flavivirus nonstructural protein NS1 is expressed as three discrete species in infected mammalian cells: an intracellular, membrane-associated form essential for viral replication, a cell surface-associated form that may be involved in signal tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e14ae0c4ec503264b5bfa74253d44c
https://doi.org/10.1128/jvi.79.17.11403-11411.2005