Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Anne-Marie Lambeir"'
Autor:
Louis Lauwerys, Lucas Beroske, Angelo Solania, Christel Vangestel, Alan Miranda, Nele Van Giel, Karuna Adhikari, Anne-Marie Lambeir, Leonie wyffels, Dennis Wolan, Pieter Van der Veken, Filipe Elvas
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-26 (2024)
Abstract Background The cysteine-aspartic acid protease caspase-3 is recognized as the main executioner of apoptosis in cells responding to specific extrinsic and intrinsic stimuli. Caspase-3 represents an interesting biomarker to evaluate treatment
Externí odkaz:
https://doaj.org/article/7d195dcb92624a9bab00b7cbe35e7adc
Autor:
Alba Ramos-Llorca, Lisse Decraecker, Valérie M. Y. Cacheux, Irena Zeiburlina, Michelle De bruyn, Louise Battut, Carlos Moreno-Cinos, Davide Ceradini, Eric Espinosa, Gilles Dietrich, Maya Berg, Ingrid De Meester, Pieter Van Der Veken, Guy Boeckxstaens, Anne-Marie Lambeir, Alexandre Denadai-Souza, Koen Augustyns
Publikováno v:
Frontiers in Chemistry, Vol 10 (2023)
Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The present study describes the synthesis and biochemica
Externí odkaz:
https://doaj.org/article/084ad8fa8c424c0d8ed10c4e2a49fa74
Autor:
Hanne Van Spaendonk, Hannah Ceuleers, Annemieke Smet, Maya Berg, Jurgen Joossens, Pieter Van der Veken, Sven M. Francque, Anne-Marie Lambeir, Joris G. De Man, Ingrid De Meester, Koen Augustyns, Benedicte Y. De Winter
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: A protease/antiprotease disbalance is observed in inflammatory bowel diseases (IBD). We therefore studied the effect of the novel serine protease inhibitor UAMC-00050 on intestinal inflammation and permeability in a chronic colitis T cell
Externí odkaz:
https://doaj.org/article/21b5fe8dc7624ef18c29d312443ee481
Autor:
Yentl Van Rymenant, Muhammet Tanc, Roos Van Elzen, An Bracke, Olivier De Wever, Koen Augustyns, Anne-Marie Lambeir, Mark Kockx, Ingrid De Meester, Pieter Van Der Veken
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Fibroblast activation protein (FAP) is a proline-selective protease that belongs to the S9 family of serine proteases. It is typically highly expressed in the tumor microenvironment (TME) and especially in cancer-associated fibroblasts, the main cell
Externí odkaz:
https://doaj.org/article/784c1afe0894428c9a73f86375b2470c
Autor:
Tommi P. Kilpeläinen, Laura Hellinen, Johannes Vrijdag, Xu Yan, Reinis Svarcbahs, Kati-Sisko Vellonen, Anne-Marie Lambeir, Henri Huttunen, Arto Urtti, Erik A.A Wallen, Timo T. Myöhänen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 128, Iss , Pp 110253- (2020)
Previous studies have shown that prolyl oligopeptidase (PREP) negatively regulates autophagy and increases the aggregation of alpha-synuclein (αSyn), linking it to the pathophysiology of Parkinson’s disease. Our earlier results have revealed that
Externí odkaz:
https://doaj.org/article/b37f7e68804249f1ba836358a446836a
Autor:
Gwendolyn Vliegen, Kaat Kehoe, An Bracke, Emilie De Hert, Robert Verkerk, Erik Fransen, Bart 's Jongers, Esther Peters, Anne-Marie Lambeir, Samir Kumar-Singh, Peter Pickkers, Philippe G Jorens, Ingrid De Meester
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231555 (2020)
The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein α (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation. Onl
Externí odkaz:
https://doaj.org/article/99554ae4708e4af4b6b120c3a9394279
Autor:
Michelle De bruyn, Hannah Ceuleers, Nikita Hanning, Maya Berg, Joris G. De Man, Paco Hulpiau, Cedric Hermans, Ulf-Håkan Stenman, Hannu Koistinen, Anne-Marie Lambeir, Benedicte Y. De Winter, Ingrid De Meester
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10711 (2021)
The protease activity in inflammatory bowel disease (IBD) and irritable bowel syndrome has been studied extensively using synthetic fluorogenic substrates targeting specific sets of proteases. We explored activities in colonic tissue from a 2,4,6-tri
Externí odkaz:
https://doaj.org/article/70a1460f3b9e4ab2ae8de5869eec14f7
Autor:
Emilie De Hert, An Bracke, Isabel Pintelon, Eline Janssens, Anne-Marie Lambeir, Pieter Van Der Veken, Ingrid De Meester
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6698 (2021)
The aim of this study was to investigate the C-terminal cleavage of (pyr)-apelin-13 in human endothelial cells with respect to the role and subcellular location of prolyl carboxypeptidase (PRCP). Human umbilical vein and aortic endothelial cells, pre
Externí odkaz:
https://doaj.org/article/1045e7d781cd489a9fe3e7991f1df108
Autor:
Alexandra Tsirigotaki, Roos Van Elzen, Pieter Van Der Veken, Anne-Marie Lambeir, Anastassios Economou
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Prolyl oligopeptidase (PREP) is conserved in many organisms across life. It is involved in numerous processes including brain function and neuropathology, that require more than its strict proteolytic role. It consists of a seven-bladed β-p
Externí odkaz:
https://doaj.org/article/8b1ac353997147ac997d70c19dcf05e6
Autor:
Rani Moons, Renate van der Wekken-de Bruijne, Stuart Maudsley, Filip Lemière, Anne-Marie Lambeir, Frank Sobott
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7884 (2020)
The intrinsically disordered protein α-synuclein plays a major role in Parkinson’s disease. The protein can oligomerize resulting in the formation of various aggregated species in neuronal cells, leading to neurodegeneration. The interaction of α
Externí odkaz:
https://doaj.org/article/bd276267780c432d91c5bf93f76d1745