Zobrazeno 1 - 10
of 634
pro vyhledávání: '"Anne-Lise Børresen Dale"'
Autor:
Thomas Fleischer, Mads Haugland Haugen, Jørgen Ankill, Laxmi Silwal‐Pandit, Anne‐Lise Børresen‐Dale, Ingrid Hedenfalk, Thomas Hatschek, Jörg Tost, Olav Engebraaten, Vessela N. Kristensen
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 2042-2059 (2024)
Treatment with the anti‐angiogenic drug bevacizumab in addition to chemotherapy has shown efficacy for breast cancer in some clinical trials, but better biomarkers are needed to optimally select patients for treatment. Here, we present an omics app
Externí odkaz:
https://doaj.org/article/943a77752b1e4da48443c28cd3393e9f
Autor:
Wanja Kildal, Karolina Cyll, Joakim Kalsnes, Rakibul Islam, Frida M. Julbø, Manohar Pradhan, Elin Ersvær, Neil Shepherd, Ljiljana Vlatkovic, Xavier Tekpli, Øystein Garred, Gunnar B. Kristensen, Hanne A. Askautrud, Tarjei S. Hveem, Håvard E. Danielsen, Tone F. Bathen, Elin Borgen, Anne-Lise Børresen-Dale, Olav Engebråten, Britt Fritzman, Olaf Johan Hartman-Johnsen, Jürgen Geisler, Gry Aarum Geitvik, Solveig Hofvind, Rolf Kåresen, Anita Langerød, Ole Christian Lingjærde, Gunhild M. Mælandsmo, Bjørn Naume, Hege G. Russnes, Kristine Kleivi Sahlberg, Torill Sauer, Helle Kristine Skjerven, Ellen Schlichting, Therese Sørlie
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e32529- (2024)
We aimed to develop deep learning (DL) models to detect protein expression in immunohistochemically (IHC) stained tissue-sections, and to compare their accuracy and performance with manually scored clinically relevant proteins in common cancer types.
Externí odkaz:
https://doaj.org/article/e0dc5fe8cfec49769db7555ff4402d86
Autor:
Thomas U. Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L. Milne, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S. Buys, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Georgia Chenevix-Trench, Christine L. Clarke, NBCS Collaborators, J. Margriet Collée, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Miriam Dwek, Diana M. Eccles, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M. Gapstur, José A. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, Anna González-Neira, Grethe I. Grenaker Alnæs, Mervi Grip, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, ABCTB Investigators, kConFab/AOCS Investigators, Milena Jakimovska, Anna Jakubowska, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N. Kristensen, Ute Krüger, Katerina Kubelka-Sabit, Allison W. Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G. Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J. MacInnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona McLean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G. Newman, Jesse Nodora, Kenneth Offit, Håkan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa V. Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Rüdiger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Ben Schöttker, Mark E. Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Lauren R. Teras, Mary Beth Terry, Diana Torres, Melissa A. Troester, Celine M. Vachon, Carolien H. M. van Deurzen, Elke M. van Veen, Philippe Wagner, Clarice R. Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Fergus J. Couch, Jacques Simard, Peter Kraft, Douglas F. Easton, Paul D. P. Pharoah, Marjanka K. Schmidt, Montserrat García-Closas, Nilanjan Chatterjee
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate wi
Externí odkaz:
https://doaj.org/article/cae5eda371db4a06b0f026b1ac32a25f
Autor:
Jaume Fores-Martos, Raimundo Cervera-Vidal, Julia Sierra-Roca, Carlos Lozano-Asencio, Vita Fedele, Sten Cornelissen, Hege Edvarsen, Irene Tadeo-Cervera, Pilar Eroles, Ana Lluch, Rafa Tabares-Seisdedos, Antonio Falcó, Laura J. Van’t Veer, Marjanka Schmidt, David A. Quigley, Anne-Lise Børresen-Dale, Vessela N. Kristensen, Allan Balmain, Joan Climent
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Polymorphisms in the PER3 gene have been associated with several human disease phenotypes, including sleep disorders and cancer. In particular, the long allele of a variable number of tandem repeat (VNTR) polymorphism has been previously lin
Externí odkaz:
https://doaj.org/article/4e917fb342074343a2b9ae2128ef604c
Autor:
Miriam Ragle Aure, Thomas Fleischer, Sunniva Bjørklund, Jørgen Ankill, Jaime A. Castro-Mondragon, OSBREAC, Anne-Lise Børresen-Dale, Jörg Tost, Kristine K. Sahlberg, Anthony Mathelier, Xavier Tekpli, Vessela N. Kristensen
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-21 (2021)
Abstract Background Abnormal DNA methylation is observed as an early event in breast carcinogenesis. However, how such alterations arise is still poorly understood. microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and pla
Externí odkaz:
https://doaj.org/article/827ee91e402744f898c0fde2f0fcf10a
Autor:
Maria Escala-Garcia, Jean Abraham, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L. Auer, Päivi Auvinen, Matthias W. Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y. Brucker, Barbara Burwinkel, Carlos Caldas, Federico Canzian, Jenny Chang-Claude, Stephen J. Chanock, Suet-Feung Chin, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Janet A. Dunn, Alison M. Dunning, Miriam Dwek, Helena M. Earl, Diana M. Eccles, A. Heather Eliassen, Carolina Ellberg, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Susan M. Gapstur, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Angela George, Graham G. Giles, David E. Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Qi Guo, Christopher A. Haiman, Niclas Håkansson, Ute Hamann, Patricia A. Harrington, Louise Hiller, Maartje J. Hooning, John L. Hopper, Anthony Howell, Chiun-Sheng Huang, Guanmengqian Huang, David J. Hunter, Anna Jakubowska, Esther M. John, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Cari M. Kitahara, Linetta B. Koppert, Peter Kraft, Vessela N. Kristensen, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Alfons Meindl, Roger L. Milne, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, William G. Newman, Andrew F. Olshan, Janet E. Olson, Håkan Olsson, Nick Orr, Paolo Peterlongo, Christos Petridis, Ross L. Prentice, Nadege Presneau, Kevin Punie, Dhanya Ramachandran, Gad Rennert, Atocha Romero, Mythily Sachchithananthan, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Lukas Schwentner, Christopher Scott, Jacques Simard, Christof Sohn, Melissa C. Southey, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Manuel R. Teixeira, Mary Beth Terry, Heather Thorne, Rob A. E. M. Tollenaar, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Clare Turnbull, Celine M. Vachon, Lizet E. van der Kolk, Qin Wang, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Argyrios Ziogas, Paul D. P. Pharoah, Per Hall, Lodewyk F. A. Wessels, Georgia Chenevix-Trench, Gary D. Bader, Thilo Dörk, Douglas F. Easton, Sander Canisius, Marjanka K. Schmidt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In breast cancer the contribution of different genetic variants to disease heritability is complex and not fully understood. Here, the authors present a network-based analysis in 84,567 patients studying ~7.3 million variants, identifying gene module
Externí odkaz:
https://doaj.org/article/66f84cb0c160487f94b95e22db3c3093
Autor:
Evita Maria Lindholm, Miriam Ragle Aure, Mads Haugland Haugen, Kristine Kleivi Sahlberg, Vessela N. Kristensen, Daniel Nebdal, Anne‐Lise Børresen‐Dale, Ole Christian Lingjærde, Olav Engebraaten
Publikováno v:
Molecular Oncology, Vol 13, Iss 10, Pp 2278-2296 (2019)
One of the hallmarks of cancer is sustained angiogenesis. Favorable results have been reported in some breast cancer (BC) patients receiving antiangiogenic therapy with bevacizumab (Bev) in combination with chemotherapy, and further knowledge on how
Externí odkaz:
https://doaj.org/article/a53595b3c7194a9b94ec95679e9735fd
Autor:
Henrik J. Johansson, Fabio Socciarelli, Nathaniel M. Vacanti, Mads H. Haugen, Yafeng Zhu, Ioannis Siavelis, Alejandro Fernandez-Woodbridge, Miriam R. Aure, Bengt Sennblad, Mattias Vesterlund, Rui M. Branca, Lukas M. Orre, Mikael Huss, Erik Fredlund, Elsa Beraki, Øystein Garred, Jorrit Boekel, Torill Sauer, Wei Zhao, Silje Nord, Elen K. Höglander, Daniel C. Jans, Hjalmar Brismar, Tonje H. Haukaas, Tone F. Bathen, Ellen Schlichting, Bjørn Naume, Consortia Oslo Breast Cancer Research Consortium (OSBREAC), Torben Luders, Elin Borgen, Vessela N. Kristensen, Hege G. Russnes, Ole Christian Lingjærde, Gordon B. Mills, Kristine K. Sahlberg, Anne-Lise Børresen-Dale, Janne Lehtiö
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Gene expression profiles can classify breast cancer into five clinically relevant subtypes. Here, the authors perform an in-depth quantitative profiling of the proteome of 45 breast tumors, and show they can recapitulate the transcriptome-based class
Externí odkaz:
https://doaj.org/article/6d38d3e496e94ae593fe7bedce5833e0
Autor:
Arie B. Brinkman, Serena Nik-Zainal, Femke Simmer, F. Germán Rodríguez-González, Marcel Smid, Ludmil B. Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J. van de Vijver, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gilles Thomas, Ivo G. Gut, John W. M. Martens, John A. Foekens, Michael R. Stratton, Hendrik G. Stunnenberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that the
Externí odkaz:
https://doaj.org/article/2a2b3c50b9604a109e1e00c8b53b792f
Autor:
Vigdis Nygaard, Anne Hansen Ree, Vegar Johansen Dagenborg, Anne-Lise Børresen-Dale, Bjørn Edwin, Åsmund Avdem Fretland, Krzysztof Grzyb, Mads H. Haugen, Gunhild M. Mælandsmo, Kjersti Flatmark
Publikováno v:
Cancer Research Communications. 3:235-244
Disease recurrence and drug resistance are major challenges in the clinical management of patients with colorectal cancer liver metastases (CLM), and because tumors are generally microsatellite stable (MSS), responses to immune therapies are poor. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c29509d38d0219c27d2c4028341cd1
https://doi.org/10.1158/2767-9764.crc-22-0295
https://doi.org/10.1158/2767-9764.crc-22-0295