Výsledky vyhledávání - "Anne-Line Anderson"

Site-Specific Conjugation of Monodispersed DOTA-PEGn to a Thiolated Diabody Reveals the Effect of Increasing PEG Size on Kidney Clearance and Tumor Uptake with Improved 64-Copper PET Imaging

Autor: Peter J. Hudson, Fabio Turatti, John E. Shively, Erasmus Poku, Lin Li, Anne-Line Anderson, David Tai Leong, Michael Paul Wheatcroft, Desiree Crow, David Colcher, James R. Bading, Jenny Carmichael, Andrew Raubitschek, Paul J. Yazaki

Publikováno v: Bioconjugate Chemistry. 22:709-716

Optimal PET imaging of tumors with radiolabeled engineered antibodies requires, among other parameters, matching blood clearance and tumor uptake with the half-life of the engineered antibody. Although diabodies have favorable molecular sizes (50 kDa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f2842b7979bdb072eb62f541262366
https://doi.org/10.1021/bc100464e

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Monodispersed DOTA-PEG–Conjugated Anti-TAG-72 Diabody Has Low Kidney Uptake and High Tumor-to-Blood Ratios Resulting in Improved64Cu PET

Autor: Erasmus Poku, John E. Shively, Debra Tamvakis, David Leong, Desiree Crow, David Colcher, James R. Bading, Fabio Turatti, Paul Robert Sanders, Anne-Line Anderson, Lawrence E. Williams, Lin Li, Andrew Raubitschek, Paul J. Yazaki, Peter J. Hudson

Publikováno v: Journal of Nuclear Medicine. 51:1139-1146

Diabodies are noncovalent dimers of single-chain antibody fragments that retain the avidity of intact IgG but have more favorable blood clearance than intact IgG. Radiometals offer a wide range of half-lives and emissions for matching imaging and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1f3f64f66c0ae684fab25edb9ba3f2
https://doi.org/10.2967/jnumed.109.074153

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Optimizing Radiolabeled Engineered Anti-p185HER2 Antibody Fragments forIn vivoImaging

Autor: Vania E. Kenanova, John E. Shively, Jeffrey Y.C. Wong, Paul J. Yazaki, Desiree Crow, Sanjiv S. Gambhir, Anna M. Wu, Andrew Raubitschek, Gobalakrishnan Sundaresan, Michael F. Press, Tove Olafsen, Anne-Line Anderson, Lin Li, Lawrence E. Williams

Publikováno v: Cancer Research. 65:5907-5916

We have recently described the in vivo properties of an iodinated anti-p185HER2 engineered antibody fragment [minibody (scFv-CH3)2; 80 kDa], made from the internalizing 10H8 monoclonal antibody. Although the 10H8 minibody showed excellent binding to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb0cc6c5a8bbd01e270d1d563321b84
https://doi.org/10.1158/0008-5472.can-04-4472

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Reduction of Kidney Uptake in Radiometal Labeled Peptide Linkers Conjugated to Recombinant Antibody Fragments. Site-Specific Conjugation of DOTA-Peptides to a Cys-Diabody

Autor: Tove Olafsen, Anne-Line Anderson, John E. Shively, Lin Li, and Andrew A. Raubitschek, Anna M. Wu

Publikováno v: Bioconjugate Chemistry. 13:985-995

Arano and co-workers (Arano et al. (1999) Cancer Res. 59, 128-134) have synthesized peptides with an N-terminal radioiodinated hippuric acid and a C-terminal lysine linked to antibody fragments via the epsilon-amino group of lysine that show reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbb11f0b900a3524ed23aa993b490a2
https://doi.org/10.1021/bc025565u

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Vinyl Sulfone Bifunctional Derivatives of DOTA Allow Sulfhydryl- or Amino-Directed Coupling to Antibodies. Conjugates Retain Immunoreactivity and Have Similar Biodistributions

Autor: John E. Shively, Shih-wa Tsai, and Andrew A. Raubitschek, Anne-Line Anderson, Lin Li, David A. Keire

Publikováno v: Bioconjugate Chemistry. 13:110-115

We have synthesized a bifunctional vinyl sulfone-cysteineamido derivative of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) that can be conjugated to the sulfhydryls of mildly reduced recombinant antibody (chimeric anti-CEA antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5aa3d98e1dc5fa1dfe3dd780261816
https://doi.org/10.1021/bc015535b

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An Improved Method for Conjugating Monoclonal Antibodies with N-Hydroxysulfosuccinimidyl DOTA

Autor: John E. Shively, Andrew Raubitschek, Jim Y. Kao, Anne-Line Anderson, Michael R. Lewis

Publikováno v: Bioconjugate Chemistry. 12:320-324

A simple, water-soluble procedure for conjugation of monoclonal antibodies to 1,4,7,10-tetraazacyclododecane-N,N‘,N‘‘,N‘‘‘-tetraacetic acid (DOTA) has been improved by optimizing pH, buffer, and temperature conditions for the preparation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92caa3fb468b52a904654dda2a8f7fdf
https://doi.org/10.1021/bc0000886

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Biodistribution and tumor imaging of an anti-CEA single-chain antibody-albumin fusion protein

Autor: Desiree Crow, Thewodros Kassa, Paul J. Yazaki, David Colcher, James R. Bading, Andrew Raubitschek, Chia-Wei Cheung, Anne-Line Anderson, Mark A. Sherman

Publikováno v: Nuclear medicine and biology. 35(2)

Albumin fusion proteins have demonstrated the ability to prolong the in vivo half-life of small therapeutic proteins/peptides in the circulation and thereby potentially increase their therapeutic efficacy. To evaluate if this format can be employed f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b715813ef226606667c5afb1b2faf0
https://pubmed.ncbi.nlm.nih.gov/18312824

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