Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anne-Laure Mahul-Mellier"'
Autor:
Hilal A. Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Antibodies against phosphorylated alpha-synuclein (aSyn) at S129 have emerged as the primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral tissues of patients with Parkinson’s disease and other neur
Externí odkaz:
https://doaj.org/article/ccd4a55ef8a5402e84ee4c5adc02d9d4
Autor:
Nathan Riguet, Anne-Laure Mahul-Mellier, Niran Maharjan, Johannes Burtscher, Marie Croisier, Graham Knott, Janna Hastings, Alice Patin, Veronika Reiterer, Hesso Farhan, Sergey Nasarov, Hilal A. Lashuel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-27 (2021)
The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal
Externí odkaz:
https://doaj.org/article/81663cd6def2472ea737c63e01d4fdd8
Autor:
Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A. Lashuel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligom
Externí odkaz:
https://doaj.org/article/a9accbe2206844e88e73f54fa7b62a03
Autor:
Sonia Donzelli, Sinead A. OSullivan, Anne-Laure Mahul-Mellier, Ayse Ulusoy, Giuliana Fusco, Senthil T. Kumar, Anass Chiki, Johannes Burtscher, Manel L.D. Boussouf, Iman Rostami, Alfonso De Simone, Donato A. Di Monte, Hilal A. Lashuel
Increasing evidence points to post-translational modifications (PTMs) as key regulators of alpha-synuclein (α-Syn) function in health and disease. However, whether these PTMs occur before or after α-Syn pathology formation and their role in regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5651dfd62b2577e95098ccbd669b3236
https://doi.org/10.1101/2023.03.24.534149
https://doi.org/10.1101/2023.03.24.534149
Autor:
Aaron T. Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R. Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M.-Y. Lee, Kelvin C. Luk, Lorena Saelices, Hilal A. Lashuel, Matthew R. Pratt
Publikováno v:
bioRxiv
The process of amyloid fibril formation remains one of the primary targets for developing diagnostics and treatments for several neurodegenerative diseases (NDDs). Amyloid-forming proteins such α-Synuclein and Tau, which are implicated in the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a9ba932fcb45cc42feb6f11579b5d
https://doi.org/10.1101/2023.03.07.531573
https://doi.org/10.1101/2023.03.07.531573
Autor:
Hilal A. Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Alpha-synuclein (aSyn) within Lewy bodies, Lewy neurites, and other pathological hallmarks of Parkinson’s disease and synucleinopathies have consistently been shown to accumulate in aggregated and phosphorylated forms of the protein, predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece1a363e47d9f98b078b7ec801c4b5b
https://doi.org/10.1101/2022.03.30.486322
https://doi.org/10.1101/2022.03.30.486322
Autor:
Senthil T. Kumar, Anne-Laure Mahul-Mellier, Ramanath Narayana Hegde, Gwladys Rivière, Rani Moons, Alain Ibáñez de Opakua, Pedro Magalhães, Iman Rostami, Sonia Donzelli, Frank Sobott, Markus Zweckstetter, Hilal A. Lashuel
Publikováno v:
Science Advances
Science advances 8(17), eabn0044 (2022). doi:10.1126/sciadv.abn0044
Science advances 8(17), eabn0044 (2022). doi:10.1126/sciadv.abn0044
The alpha-synuclein mutation E83Q, the first in the NAC domain of the protein, was recently identified in a patient with dementia with Lewy bodies. We investigated the effects of this mutation on the aggregation of aSyn monomers and the structure, mo
Autor:
Anne-Laure Mahul-Mellier, Niran Maharjan, Marie Croisier, Laura Weerens, Johannes Burtscher, Marion Leleu, Graham Knott, Fabien Kuttler, Hilal A. Lashuel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Although converging evidence point to α-synuclein aggregation and Lewy body (LB) formation as central events in Parkinson’s disease, the molecular mechanisms that regulate these processes and their role in disease pathogenesis remain
Autor:
Senthil Kumar, Frank Sobott, Markus Zweckstetter, Rani Moons, Gwladys Rivière, Sonia Donzelli, Pedro Magalhaes, Iman Rostami, Anne-Laure Mahul-Mellier, Alain Ibáñez de Opakua, Hilal A. Lashuel, Ramanath Narayana Hegde
A novel mutation (E83Q), the first in the NAC domain of alpha-synuclein (aSyn), was recently identified in a patient with dementia with Lewy bodies. We investigated the effects of this mutation on the aggregation of aSyn monomers and the structure, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b96388711e4c66080020c090a2c6295
https://doi.org/10.1101/2021.11.21.469421
https://doi.org/10.1101/2021.11.21.469421
Autor:
Hilal A. Lashuel, Giovanni Dietler, Urszula Cendrowska, Anass Chiki, Sean M. DeGuire, Nathan Riguet, Francesco S. Ruggeri, Anne-Laure Mahul-Mellier, Sophie Vieweg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0613b886a2e99d7ccb78bc654fc96f
https://doi.org/10.15252/rc.2022402060
https://doi.org/10.15252/rc.2022402060