Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.

Autor: Anne-Laure Leoni, Bruno Gavillet, Jean-Sébastien Rougier, Céline Marionneau, Vincent Probst, Solena Le Scouarnec, Jean-Jacques Schott, Sophie Demolombe, Patrick Bruneval, Christopher L H Huang, William H Colledge, Andrew A Grace, Hervé Le Marec, Arthur A Wilde, Peter J Mohler, Denis Escande, Hugues Abriel, Flavien Charpentier

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9298 (2010)

Loss-of-function mutations in SCN5A, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and Brugada syndrome, which both exhibit variable phenotypic penetrance of conduction defects. We investigated the m

Externí odkaz: https://doaj.org/article/cdbbe44739414c65b378bc6914b4ef64

Supplementary_Data - Historical control data for hematology parameters obtained from toxicity studies performed on different Wistar rat strains: Acceptable value ranges, definition of severity degrees, and vehicle effects

Autor: Kort, Marlies De, Weber, Klaus, Wimmer, Björn, Wilutzky, Katharina, Neuenhahn, Patricia, Allingham, Philip, Anne-Laure Leoni

Supplementary_Data for Historical control data for hematology parameters obtained from toxicity studies performed on different Wistar rat strains: Acceptable value ranges, definition of severity degrees, and vehicle effects by Marlies de Kort, Klaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e43bb8511241c76bd4a4a906c5bd53

New Method for Sperm Evaluation by 3-Dimensional Laser Scanning Microscopy in Different Laboratory Animal Species

Autor: Andres König, Marc Kunze, Patricia Ordóñez, Diana Fendl, Roberto Quirici, Pradeep Takawale, Wolfram Riedel, Jerry F. Hardisty, Yoshimasa Okazaki, Klaus Weber, Alexander Waletzky, Anne-Laure Leoni, Ivano Romano, Javier Rivera, Felix Hein, Susanne Paepke

Publikováno v: International Journal of Toxicology. 33:353-361

Sperm analysis is one of the end points in reproductive toxicology studies. Different methods for quantitative sperm analysis have been described. For qualitative morphological sperm analysis, either such techniques or smears of sperm and histologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d20337a75a6ca46d21b1e022f192512
https://doi.org/10.1177/1091581814545243

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block

Autor: Isabelle Bidaud, Pietro Mesirca, Kevin Wickman, Stéphane Evain, François Briec, Joerg Striessnig, Angelo G. Torrente, Laurine Marger, Anne Laure Leoni, Antony Chung You Chong, Flavien Charpentier, Matteo E. Mangoni, Khai Le Quang, Matthias Baudot, Joël Nargeot

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (7), pp.E932--941. ⟨10.1073/pnas.1517181113⟩

International audience; Dysfunction of pacemaker activity in the sinoatrial node (SAN) underlies "sick sinus" syndrome (SSS), a common clinical condition characterized by abnormally low heart rate (bradycardia). If untreated, SSS carries potentially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4187b581f85d3f4ea5a2447cb97353a6
https://hal.archives-ouvertes.fr/hal-01831593/document

Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block

Autor: Anne Bourge, Khai Le Quang, Olivier Bignolais, Aziza El Harchi, Julien Piron, Patrice Naud, Anne-Laure Leoni, Flavien Charpentier, François Briec, Sophie Demolombe

Publikováno v: Journal of Molecular and Cellular Cardiology. 51:713-721

Complete atrioventricular block (CAVB) and related ventricular bradycardia are known to induce ventricular hypertrophy and arrhythmias. Different animal models of CAVB have been established with the most common being the dog model. Related studies we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ce3b87773940000449bb6b6ed0cbd9
https://doi.org/10.1016/j.yjmcc.2011.07.008