HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status

Autor: Anne-Laure Leblond, Birgit Helmchen, Maliki Ankavay, Daniela Lenggenhager, Jasna Jetzer, Fritjof Helmchen, Hueseyin Yurtsever, Rossella Parrotta, Marc E. Healy, Amiskwia Pöschel, Enni Markkanen, Nasser Semmo, Martin Ferrié, Laurence Cocquerel, Harald Seeger, Helmut Hopfer, Beat Müllhaupt, Jérôme Gouttenoire, Darius Moradpour, Ariana Gaspert, Achim Weber

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic, particularly renal, manifestations. However, the underlying mechanisms are incompletely understood. Here, we repor

Externí odkaz: https://doaj.org/article/2e0acd6efb7748d6ab4fa79b0d50a92c

Bone marrow mononuclear stem cells: potential in the treatment of myocardial infarction

Autor: Anne-Laure Leblond, John O’Sullivan, Noel Caplice

Publikováno v: Stem Cells and Cloning: Advances and Applications, Vol 2009, Iss default, Pp 11-19 (2009)

Anne-Laure Leblond, John O’Sullivan, Noel Caplice1Centre for Research in Vascular Biology (CRVB), Biosciences Institute, University College Cork, Cork, IrelandAbstract: Despite advances in the management of myocardial infarction, congestive heart f

Externí odkaz: https://doaj.org/article/f06cc6aac9c4480c986f918d30eff0fe

Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Autor: Elena Kotsiliti, Valentina Leone, Svenja Schuehle, Olivier Govaere, Hai Li, Monika J. Wolf, Helena Horvatic, Sandra Bierwirth, Jana Hundertmark, Donato Inverso, Laimdota Zizmare, Avital Sarusi-Portuguez, Revant Gupta, Tracy O’Connor, Anastasios D. Giannou, Ahmad Mustafa Shiri, Yehuda Schlesinger, Maria Garcia Beccaria, Charlotte Rennert, Dominik Pfister, Rupert Öllinger, Iana Gadjalova, Pierluigi Ramadori, Mohammad Rahbari, Nuh Rahbari, Marc Healy, Mirian Fernández-Vaquero, Neda Yahoo, Jakob Janzen, Indrabahadur Singh, Chaofan Fan, Xinyuan Liu, Monika Rau, Martin Feuchtenberger, Eva Schwaneck, Sebastian J. Wallace, Simon Cockell, John Wilson-Kanamori, Prakash Ramachandran, Celia Kho, Timothy J. Kendall, Anne-Laure Leblond, Selina J. Keppler, Piotr Bielecki, Katja Steiger, Maike Hofmann, Karsten Rippe, Horst Zitzlesberger, Achim Weber, Nisar Malek, Tom Lüdde, Mihael Vucur, Hellmut G. Augustin, Richard Flavell, Oren Parnas, Roland Rad, Olivier Pabst, Neil C. Henderson, Samuel Huber, Andrew Macpherson, Percy Knolle, Manfred Claasen, Andreas Geier, Christoph Trautwein, Kristian Unger, Eran Elinav, Ari Waisman, Zeinab Abdullah, Dirk Haller, Frank Tacke, Quentin M. Anstee, Mathias Heikenwalder

Publikováno v: Kotsiliti, E, Leone, V, Schuehle, S, Govaere, O, Li, H, Wolf, M J, Horvatic, H, Bierwirth, S, Hundertmark, J, Inverso, D, Zizmare, L, Sarusi-Portuguez, A, Gupta, R, O'Connor, T, Giannou, A D, Shiri, A M, Schlesinger, Y, Beccaria, M G, Rennert, C, Pfister, D, Öllinger, R, Gadjalova, I, Ramadori, P, Rahbari, M, Rahbari, N, Healy, M, Fernández-Vaquero, M, Yahoo, N, Janzen, J, Singh, I, Fan, C, Liu, X, Rau, M, Feuchtenberger, M, Schwaneck, E, Wallace, S J, Cockell, S, Wilson-Kanamori, J, Ramachandran, P, Kho, C, Kendall, T J, Leblond, A-L, Keppler, S J, Bielecki, P, Steiger, K, Hofmann, M, Rippe, K, Zitzlesberger, H, Weber, A, Malek, N, Lüdde, T, Vucur, M, Augustin, H G, Flavell, R, Parnas, O, Rad, R, Pabst, O, Henderson, N C, Huber, S, Macpherson, A, Knolle, P, Claasen, M, Geier, A, Trautwein, C, Unger, K, Elinav, E, Waisman, A, Abdullah, Z, Haller, D, Tacke, F, Anstee, Q M & Heikenwalder, M 2023, ' Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling ', Journal of Hepatology . https://doi.org/10.1016/j.jhep.2023.04.037

BACKGROUND & AIMS: The progression of nonalcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. The gut-liver axis contributes to NASH, but the mechanisms involved and the consequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e25f605ee9738f8f6026a70bbfe8ba

Microfluidic-Based Immunohistochemistry Combined With Next-Generation Sequencing on Diagnostic Tissue Sections for Detection of Tumoral BRAF V600E Mutation

Autor: Diego Gabriel Dupouy, Markus Rechsteiner, Amy Jones, Alex Soltermann, Anne-Laure Leblond, Saska Brajkovic

OBJECTIVES Tailored diagnostics requires immunohistochemistry (IHC) and next generation sequencing (NGS). Here we combined on a single paraffin-embedded slide microfluidic-based IHC (micro-IHC) and NGS for BRAF V600E mutation detection in BRAFomas. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234a83c6f6c5aaa5046ec45b1f951c23
https://www.zora.uzh.ch/id/eprint/171738/

Assessment of predictive biomarkers in cancer tissues using micro-immunohistochemistry followed by DNA sequencing

Autor: Anne-Laure Leblond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9d3ac50c78cbee346ea0abd0e405e89
https://doi.org/10.26226/morressier.5b4709896f4cb300109519c6