Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

Autor: Romain Ollier, Aline Fuchs, Florence Gauye, Katarzyna Piorkowska, Sébastien Menant, Monisha Ratnam, Paolo Montanari, Florence Guilhot, Didier Phillipe, Mickael Audrain, Anne-Laure Egesipe, Damien Névoltris, Tamara Seredenina, Andrea Pfeifer, Marie Kosco-Vilbois, Tariq Afroz

Publikováno v: mAbs, Vol 15, Iss 1 (2023)

ABSTRACTOptimal pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) are essential to achieve the desired pharmacological benefits in patients. To accomplish this, we followed an approach comprising structure-based mAb charge e

Externí odkaz: https://doaj.org/article/9a5ae63d53e7442fa5091ec231d7f99f

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Autor: Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that

Externí odkaz: https://doaj.org/article/4ba0b6d9e607460d92755869c0269433

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Autor: Guillem Colell, Rodrigo L. dos Santos, Luís Miguel Monteiro, Andreia Bernardo, Claire Navarro, Nicolas Lévy, Lino Ferreira, Anna Rosell, Anne-Laure Egesipe, Daniel Thornton, Xavier Nissan, João Pedro de Magalhães, James C. Smith, Alessandro Ori, Karim Harhouri, Luís M.B.B. Estronca, Deolinda Santinha, Helena Vazão, Tania Rafaela Vale Carvalho, Annachiara De Sandre-Giovannoli, Patrícia R. Pitrez

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.4110. ⟨10.1038/s41467-020-17901-2⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.4110. ⟨10.1038/s41467-020-17901-2⟩
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License.
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf097f9d9bc35c3035baa5f8c47888aa

Substrate Topography Modulates Cell Aging on a Progeria Cell Model

Autor: Luís M.B.B. Estronca, Lino Ferreira, Helena Vazão, Patrícia R. Pitrez, Anne-Laure Egesipe, Claire Navarro, Nicolas Lévy, Annachiara De Sandre-Giovannoli, Amélie Le Corf, Xavier Nissan

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Biomaterials Science and Engineering
ACS Biomaterials Science and Engineering, 2018, 4 (5), pp.1498-1504
HAL
ACS Biomaterials Science & Engineering
ACS Biomaterials Science and Engineering, ACS, 2018, 4 (5), pp.1498-1504

Aging is characterized by a progressive accumulation of cellular damage, which leads to impaired function. Little is known whether substrates can influence cell aging. This is of utmost importance in the development of medical devices that are in con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169857bdc6998ec009ed3fc9daa5c4e4
https://hdl.handle.net/10316/92391

A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells

Autor: Xavier Nissan, Anne-Laure Jaskowiak, Alessandra Lo Cicero, Anne-Laure Egesipe, Benjamin Brinon, Annachiara De Sandre-Giovannoli, Lino Ferreira, Nicolas Lévy, Johana Tournois, Patrícia R. Pitrez

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, ⟨10.1038/srep34798⟩
Scientific Reports, Nature Publishing Group, 2016, 6, 〈10.1038/srep34798〉
Scientific Reports, 2016, 6, ⟨10.1038/srep34798⟩

Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder that causes systemic accelerated aging in children. Thanks to the pluripotency and self-renewal properties of induced pluripotent stem cells (iPSC), HGPS iPSC-based modeling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b537d79b1ba1e4d77ef83e46b1c839