Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling.

Autor: Renee Wei-Yan Chow, Hajime Fukui, Wei Xuan Chan, Kok Soon Justin Tan, Stéphane Roth, Anne-Laure Duchemin, Nadia Messaddeq, Hiroyuki Nakajima, Fei Liu, Nathalie Faggianelli-Conrozier, Andrey S Klymchenko, Yap Choon Hwai, Naoki Mochizuki, Julien Vermot

Publikováno v: PLoS Biology, Vol 20, Iss 1, p e3001505 (2022)

In the clinic, most cases of congenital heart valve defects are thought to arise through errors that occur after the endothelial-mesenchymal transition (EndoMT) stage of valve development. Although mechanical forces caused by heartbeat are essential

Externí odkaz: https://doaj.org/article/f8b10f232dab4b68966608ab62009b85

The Zebrafish Anillin-eGFP Reporter Marks Late Dividing Retinal Precursors and Stem Cells Entering Neuronal Lineages.

Autor: Meret Cepero Malo, Anne-Laure Duchemin, Luca Guglielmi, Eva Patzel, Saadettin Sel, Gerd U Auffarth, Matthias Carl, Lucia Poggi

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170356 (2017)

Monitoring cycling behaviours of stem and somatic cells in the living animal is a powerful tool to better understand tissue development and homeostasis. The tg(anillin:anillin-eGFP) transgenic line carries the full-length zebrafish F-actin binding pr

Externí odkaz: https://doaj.org/article/32c03ea6454244cd9b6d9a466a5c57af

Transcriptome analysis of the zebrafish atoh7−/− Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases

Autor: Felipe Gajardo, Anne-Laure Duchemin, Michael P. Eichenlaub, Enrico Domenici, Michele Filosi, Miguel L. Allende, Lucia Poggi, Giuseppina Covello, Mirana Ramialison, David R. Powell, Beatrice F. Tremonti, Fernando J. Rossello, Jose M. Polo, John Ngai

Publikováno v: FASEB bioAdvances, vol 2, iss 7
FASEB BioAdvances
FASEB BioAdvances, [Hoboken, NJ] : John Wiley & Sons, Inc., [2019]-, 2020, ⟨10.1096/fba.2020-00030⟩
FASEB BioAdvances, Vol 2, Iss 7, Pp 434-448 (2020)

Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. A number of studies have emerged establishingATOH7as a retinal disease gene. Remar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0c48742b42dee2d54fbb12f0f1a7a6
Wiley Online Library

Mechanotransduction in cardiovascular morphogenesis and tissue engineering

Autor: Hélène Vignes, Anne-Laure Duchemin, Julien Vermot, Renee Chow

Publikováno v: Current opinion in genetics & development
Current opinion in genetics & development, 2019, 57, ⟨10.1016/j.gde.2019.08.002⟩
Current Opinion in Genetics and Development
Current Opinion in Genetics and Development, Elsevier, 2019, 57, ⟨10.1016/j.gde.2019.08.002⟩

Cardiovascular morphogenesis involves cell behavior and cell identity changes that are activated by mechanical forces associated with heart function. Recently, advances in in vivo imaging, methods to alter blood flow, and computational modelling have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280b8b02d5f114f5802bc0497a328642
https://hal.archives-ouvertes.fr/hal-02516546

Mechanically activated Piezo channels control outflow tract valve development through Yap1 and Klf2-Notch signaling axis

Autor: Julien Vermot, Hélène Vignes, Anne-Laure Duchemin

Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375570461898a322de36063db06c111f