NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells.

Autor: Blandine C Mercier, Erwan Ventre, Marie-Laure Fogeron, Anne-Laure Debaud, Martine Tomkowiak, Jacqueline Marvel, Nathalie Bonnefoy

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e42170 (2012)

Pattern recognition receptors (PRR), like Toll-like receptors (TLR) and NOD-like receptors (NLR), are involved in the detection of microbial infections and tissue damage by cells of the innate immune system. Recently, we and others have demonstrated

Externí odkaz: https://doaj.org/article/ba3539a8b1a24ffd8782d7946bbd0cca

Protein Kinase Cδ Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell-Defective Apoptosis and Hyperproliferation

Autor: Gillian I. Rice, Marcin Szynkiewicz, Nicole Fabien, Patrick M. Gaffney, Sarah B. Daly, James O'Sullivan, Alexandre Belot, John Brognard, Shameem Fawdar, Pierre Cochat, Anne Perrine Foray, Jill E. Urquhart, Jonathan E. Dickerson, Natalie Stephenson, Marie Therese Zabot, Josephine Mayer, Flore Rozenberg, Paul R. Kasher, Graeme C.M. Black, Yanick J. Crow, Eleanor W. Trotter, Laurent Juillard, Anne Laure Debaud, Bruno Ranchin, Christophe Malcus, Michael W. Beresford, Pierre Lebon, Jean Francois Eliaou, Nathalie Bonnefoy, Bohdan Waszkowycz, Sanjeev S. Bhaskar, Céline René, Isabelle Rouvet, Leslie G. Biesecker, Anna A. Marusiak

Publikováno v: Arthritis & Rheumatism. 65:2161-2171

Objective: Systemic lupus erythematosus (SLE) is a prototype autoimmune disease, assumed to occur due to a complex interplay of environmental and genetic factors. Rare causes of monogenic SLE have been described, providing unique insights into fundam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97166175d7ab8281a8f421519cc464f7
https://doi.org/10.1002/art.38008

Synthesis and biological activities of new di- and trimeric quinoline derivatives

Autor: Sidonie Broch, Pascale Moreau, Anne-Laure Debaud, Hélène Henon, Marie-Laure Fogeron, Nathalie Bonnefoy-Berard, Fabrice Anizon

Publikováno v: Bioorganic & Medicinal Chemistry. 18:7132-7143

The synthesis of non-peptidic helix mimetics based on a trimeric quinoline scaffold is described. The ability of these new compounds, as well as their synthetic dimeric intermediates, to bind to various members of the Bcl-2 protein anti-apoptotic gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc1181aec155f581f63d866a3421f1c
https://doi.org/10.1016/j.bmc.2010.07.029

Tax Protein-induced Expression of Antiapoptotic Bfl-1 Protein Contributes to Survival of Human T-cell Leukemia Virus Type 1 (HTLV-1)-infected T-cells

Autor: Jean-Michel Mesnard, Renaud Mahieux, Anne-Laure Debaud, Vincent Moncollin, Hélène Valentin, Aurélien Riquet, Madeleine Duc Dodon, Olivier Hermine, Nathalie Bonnefoy, Marie-Claude Biémont-Trescol, Marlène Pierre, Héloïse Macaire, Louis Gazzolo

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287, pp.21357-21370. ⟨10.1074/jbc.M112.340992⟩
Journal of Biological Chemistry, 2012, 287, pp.21357-21370. ⟨10.1074/jbc.M112.340992⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (25), pp.21357-21370. ⟨10.1074/jbc.M112.340992⟩

Human T lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL). ATLL is a severe malignancy with no effective treatment. HTLV-1 regulatory proteins Tax and HTLV-1 basic leucine zipper factor (HBZ) play a ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aada4e4f696a8ec04aba9c9c98dc3cf3
https://hal-ens-lyon.archives-ouvertes.fr/ensl-00807696/file/PIIS0021925820498278.pdf

C-terminal Residues Regulate Localization and Function of the Antiapoptotic Protein Bfl-1

Autor: Anne-Laure Debaud, Richard Haser, Marie-Claude Trescol-Biémont, Gaelle Brien, Nicolas Cauquil, Olivier Geneste, Nushin Aghajari, Nathalie Bonnefoy-Berard, François M. Vallette, Lisa Oliver, Xavier Robert

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (44), pp.30257-30263. ⟨10.1074/jbc.M109.040824⟩

Unlike other antiapoptotic members of the Bcl-2 family, Bfl-1 does not contain a well defined C-terminal transmembrane domain, and whether the C-terminal tail of Bfl-1 functions as a membrane anchor is not yet clearly established. The molecular model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7ba6f612134fdff5b9907be69c2c05
https://hal.archives-ouvertes.fr/hal-03094649