Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Anne-Laure Blayo"'
Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
Autor:
Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Scott J. Novick, Anne-Laure Blayo, Trey Patton, Desiree E. Mendes, Philippe Diaz, Theodore M. Kamenecka, Patrick R. Griffin, Travis S. Hughes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural ra
Externí odkaz:
https://doaj.org/article/27b2fda7dc814baabc2b2a797db6f945
Autor:
Richard Brust, Jinsai Shang, Jakob Fuhrmann, Sarah A. Mosure, Jared Bass, Andrew Cano, Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Anne-Laure Blayo, Patrick R. Griffin, Theodore M. Kamenecka, Travis S. Hughes, Douglas J. Kojetin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a target for insulin sensitizing drugs. Here the authors combine NMR, X-ray crystallography and MD simulations and report a structural mechanism for eliciting PPARγ inverse agonism, where
Externí odkaz:
https://doaj.org/article/83045b413545471dafc949ec4db32b64
Autor:
Anne-Laure Blayo, Laurène Deshons, Alexia Dumont, Christel Franchet, Célia Halter, Ludovic Herbin, Gaël Hommet, Stanislas Mayer, Alban Bessede, Imane Nafia, Marjorie Sidhoum, Xavier Leroy, Stéphan Schann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/d39d0b87f1fc43e1b9ad9bb03c60bc9a
Autor:
Rebecca L. Frkic, Andrew C. Marshall, Anne-Laure Blayo, Tara L. Pukala, Theodore M. Kamenecka, Patrick R. Griffin, John B. Bruning
Publikováno v:
iScience, Vol 5, Iss , Pp 69-79 (2018)
Summary: Peroxisome proliferator activated receptor γ (PPARγ) is a nuclear receptor and target for antidiabetics that increase insulin sensitivity. Owing to the side effects of PPARγ full agonists, research has recently focused on non-activating l
Externí odkaz:
https://doaj.org/article/5fd6f291f7604046852cef8eccc0113d
Autor:
Ian M. Chrisman, Michelle D. Nemetchek, Ian Mitchelle S. de Vera, Jinsai Shang, Zahra Heidari, Yanan Long, Hermes Reyes-Caballero, Rodrigo Galindo-Murillo, Thomas E. Cheatham, Anne-Laure Blayo, Youseung Shin, Jakob Fuhrmann, Patrick R. Griffin, Theodore M. Kamenecka, Douglas J. Kojetin, Travis S. Hughes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor. Here the authors provide insights into PPARγ activation by combining fluorine (19F) NMR and molecular dynamics simulations to characterize the nuclear receptor conforma
Externí odkaz:
https://doaj.org/article/85e8ea413a844fe895eaaf28a09a3b89
Autor:
Rebecca L. Frkic, Jordan L. Pederick, Aimee J. Horsfall, Blagojce Jovcevski, Elise E. Crame, Wioleta Kowalczyk, Tara L. Pukala, Mi Ra Chang, Jie Zheng, Anne-Laure Blayo, Andrew D. Abell, Theodore M. Kamenecka, Joshua S. Harbort, Jeffrey R. Harmer, Patrick R Griffin, John B. Bruning
Publikováno v:
ACS Chemical Biology. 18:1115-1123
Autor:
Anne-Laure Blayo, Claire Jouffroy-Zeller, Nathalie Lenne, Imane Nafia, Patricia Zerr, Stéphan Schann, Xavier Leroy
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Thibaut Brugat, Francesco Bergami, Baptiste Rugeri, Aurélie Janvier, Edith Steinberg, Luc Baron, Mandy Recolet, Xavier Wirth, Meriem Semache, Antoine Mousson, Camille Dietsch, Quentin Ruet, Orphée Blanchard, Célia Jacoberger-Foissac, Isabelle Cousineau, Maleck Kadiri, Anne-Laure Blayo, Christel Franchet, Stanislas Mayer, John Stagg, Nathalie Lenne, Stephan Schann
Publikováno v:
Cancer Research. 83:4961-4961
A large-scale meta-analysis has recently identified Protease-activated receptor 2 (PAR2) gene expression to be significantly associated with resistance to immune checkpoint blockade (ICB) in cancer patients and preclinical models. PAR2 and its ligand
Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
Autor:
Michelle D. Nemetchek, Desiree E. Mendes, Philippe Diaz, Ian M. Chrisman, Trey Patton, Anne-Laure Blayo, Travis S. Hughes, Zahra Heidari, Scott J. Novick, Theodore M. Kamenecka, Patrick R. Griffin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The repressive states of nuclear receptors (i.e., apo or bound to antagonists or inverse agonists) are poorly defined, despite the fact that nuclear receptors are a major drug target. Most ligand bound structures of nuclear receptors, including perox
Autor:
Sonia Cantel, Jean-Alain Fehrentz, Severine Denoyelle, Catherine Oiry, Gimena Fernandez, Mario Perello, Sylvie Peraldi-Roux, Jean-Louis Banères, Céline M'Kadmi, Guadalupe García Romero, Jacky Marie, Sophie Mary, Mathieu Maingot, Marjorie Damian, Anne-Laure Blayo, Jérémie Neasta, Khoubaib Ben Haj Salah
Publikováno v:
Journal of Clinical Chemistry and Clinical Biochemistry
Journal of Clinical Chemistry and Clinical Biochemistry, 2020, ⟨10.1021/acs.jmedchem.9b02122⟩
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (19), pp.10796-10815. ⟨10.1021/acs.jmedchem.9b02122⟩
Journal of Clinical Chemistry and Clinical Biochemistry, 2020, ⟨10.1021/acs.jmedchem.9b02122⟩
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (19), pp.10796-10815. ⟨10.1021/acs.jmedchem.9b02122⟩
International audience; GHSR controls, among others, growth hormone and insulin secretion, adiposity, feeding and glucose metabolism. Therefore, an inverse agonist ligand capable of selectively targeting GHSR and reducing its high constitutive activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff4a1b5d5080c225244a11ba684780e
https://hal.archives-ouvertes.fr/hal-03023656
https://hal.archives-ouvertes.fr/hal-03023656