Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Anne-Katrin Rohlfing"'
Autor:
Jasmin Kazenwadel, Georgy Berezhnoy, Claire Cannet, Hartmut Schäfer, Tobias Geisler, Anne-Katrin Rohlfing, Meinrad Gawaz, Uta Merle, Christoph Trautwein
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-15 (2023)
Abstract Background Diagnostic approaches like the nuclear magnetic resonance spectroscopy (NMR) based quantification of metabolites, lipoproteins, and inflammation markers has helped to identify typical alterations in the blood serum of COVID-19 pat
Externí odkaz:
https://doaj.org/article/18f49d0ac08c4a6ab88add1ec1b43ffb
Autor:
Manuel Sigle, Anne-Katrin Rohlfing, Martin Kenny, Sophia Scheuermann, Na Sun, Ulla Graeßner, Verena Haug, Jessica Sudmann, Christian M. Seitz, David Heinzmann, Katja Schenke-Layland, Patricia B. Maguire, Axel Walch, Julia Marzi, Meinrad Paul Gawaz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Spatial transcriptomics of histological sections have revolutionized research in life sciences and enabled unprecedented insights into genetic processes involved in tissue reorganization. However, in contrast to genomic analysis, the actual
Externí odkaz:
https://doaj.org/article/b7ac1719d6d84968857dbc7a99739fe6
Autor:
Anne-Katrin Rohlfing, Kyra Kolb, Manuel Sigle, Melanie Ziegler, Alexander Bild, Patrick Münzer, Jessica Sudmann, Valerie Dicenta, Tobias Harm, Mailin-Christin Manke, Sascha Geue, Marcel Kremser, Madhumita Chatterjee, Chunguang Liang, Hendrik von Eysmondt, Thomas Dandekar, David Heinzmann, Manina Günter, Saskia von Ungern-Sternberg, Manuela Büttcher, Tatsiana Castor, Stine Mencl, Friederike Langhauser, Katharina Sies, Diyaa Ashour, Mustafa Caglar Beker, Michael Lämmerhofer, Stella E. Autenrieth, Tilman E. Schäffer, Stefan Laufer, Paulina Szklanna, Patricia Maguire, Matthias Heikenwalder, Karin Anne Lydia Müller, Dirk M. Hermann, Ertugrul Kilic, Ralf Stumm, Gustavo Ramos, Christoph Kleinschnitz, Oliver Borst, Harald F. Langer, Dominik Rath, Meinrad Gawaz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.
Externí odkaz:
https://doaj.org/article/bff45f142b4844968bc8a69ceae8231a
Autor:
Jeremy A. Nestele, Anne-Katrin Rohlfing, Valerie Dicenta, Alexander Bild, Daniela Eißler, Frederic Emschermann, Marcel Kremser, Konstantin Krutzke, Tilman E. Schäffer, Oliver Borst, Moran Levi, Netanel Korin, Meinrad Paul Gawaz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 11 (2021)
Traditional antithrombotic agents commonly share a therapy-limiting side effect, as they increase the overall systemic bleeding risk. A novel approach for targeted antithrombotic therapy is nanoparticles. In other therapeutic fields, nanoparticles ha
Externí odkaz:
https://doaj.org/article/9e07861e69874a309e3820f47d363fd4
Autor:
Álvaro Petersen-Uribe, Marcel Kremser, Anne-Katrin Rohlfing, Tatsiana Castor, Kyra Kolb, Valerie Dicenta, Frederic Emschermann, Bo Li, Oliver Borst, Dominik Rath, Karin Anne Lydia Müller, Meinrad Paul Gawaz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11179 (2021)
Platelets play a significant role in atherothrombosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is critically involved in the regulation of LDL metabolism and interacts with platelet function. The effect of PCSK9 in platelet function is
Externí odkaz:
https://doaj.org/article/eb455493ebb14e6d8aeb70b43772ca42
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Aquaporins occupy an essential role in sustaining the salt/water balance in various cells types and tissues. Here, we present new insights into aqp-8 expression and regulation in Caenorhabditis elegans. We show, that upon exposure to osmotic stress,
Externí odkaz:
https://doaj.org/article/f114ae395041457494b80aa4451b0a77
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001267 (2011)
The molecular mechanisms of animal cell osmoregulation are poorly understood. Genetic studies of osmoregulation in yeast have identified mucin-like proteins as critical regulators of osmosensitive signaling and gene expression. Whether mucins play si
Externí odkaz:
https://doaj.org/article/e2014672d5fe4a06a31f914fc1dbccea
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9010 (2010)
The soil-dwelling nematode C. elegans is a powerful system for comparative molecular analyses of environmental stress response mechanisms. Infection of worms with bacterial and fungal pathogens causes the activation of well-characterized innate immun
Externí odkaz:
https://doaj.org/article/e3142e04edc2454993c8ca70fa7e6396
Autor:
Tobias Harm, Moritz Frey, Kristina Dittrich, Andreas Goldschmied, Anne-Katrin Rohlfing, Xiaoqing Fu, Adrian Brun, Tatsiana Castor, Dominik Rath, Karin Müller, Michael Lammerhofer, Meinrad Gawaz
Publikováno v:
Thrombosis and Haemostasis. 123:585-596
Background Platelets are key players in the pathophysiology of coronary artery disease (CAD) and platelet hyperreactivity leads to increased risk of developing adverse cardiovascular events. Further, significant changes in the platelet lipidome occur
Autor:
Annalena Fink, Anne-Katrin Rohlfing, Valerie Dicenta, David Schaale, Marcel Kremser, Zoi Laspa, Manuel Sigle, Xiaoqing Fu, Andreas Pelzer, Melina Fischer, Patrick Münzer, Tatsiana Castor, Karin Anne Lydia Müller, Oliver Borst, Michael Lämmerhofer, Meinrad Paul Gawaz
Publikováno v:
Thrombosis and Haemostasis.
Introduction Hemolysis results in release of free hemoglobin and hemin liberation from erythrocytes. Hemin has been described to induce platelet activation and to trigger thrombosis. Methods We evaluated the effect of hemin on platelet function and s