Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anne-Kathrin Lutz"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S470-S471 (2023)
Externí odkaz:
https://doaj.org/article/b20cab466a844526b4706b1783310a44
Autor:
Ekaterina Atanasova, Andrea Pérez Arévalo, Ines Graf, Rong Zhang, Juergen Bockmann, Anne-Kathrin Lutz, Tobias M. Boeckers
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Autism spectrum disorder (ASD) is mainly characterized by deficits in social interaction and communication and repetitive behaviors. Known causes of ASD are mutations of certain risk genes like the postsynaptic protein SHANK3 and
Externí odkaz:
https://doaj.org/article/508bd4040ef242d8bc937e9009dc09be
Autor:
Berra Yildiz, Lisa Schiedt, Medhanie Mulaw, Jürgen Bockmann, Sarah Jesse, Anne-Kathrin Lutz, Tobias M. Boeckers
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Phelan-McDermid syndrome (PMS) is a syndromic form of Autism Spectrum Disorders (ASD) classified as a rare genetic neurodevelopmental disorder featuring global developmental delay, absent or delayed speech, ASD-like behaviour and neonatal skeletal mu
Externí odkaz:
https://doaj.org/article/82daea9de3a9404887a4b162e1af44a5
Autor:
Anne-Kathrin Lutz, Helen Friedericke Bauer, Valentin Ioannidis, Michael Schön, Tobias M. Boeckers
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
SHANK3 is a scaffolding protein implicated in autism spectrum disorders (ASD). Its function at excitatory glutamatergic synapses has been studied for the last two decades, however, tissue-specific expression patterns as well as its subcellular locali
Externí odkaz:
https://doaj.org/article/82003481d8404a9dab45d0620ea1e1d3
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Whole animal perfusion is a well-established method that has been used for the past decades in multiple research fields. Particularly, it has been very important for the study of the brain. The rapid and uniform fixation of tissue is essential for th
Externí odkaz:
https://doaj.org/article/c2348f1453be4f698e9af0311c7a73ad
Autor:
Anne-Kathrin Lutz, Andrea Pérez Arévalo, Valentin Ioannidis, Nadine Stirmlinger, Maria Demestre, Richard Delorme, Thomas Bourgeron, Tobias M. Boeckers
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
SHANK2 (ProSAP1) is a postsynaptic scaffolding protein of excitatory synapses in the central nervous system and implicated in the development of autism spectrum disorders (ASD). Patients with mutations in SHANK2 show autism-like behaviors, developmen
Externí odkaz:
https://doaj.org/article/62de73e79ade401bb205c8be84ad16a1
Autor:
Julia Higelin, Alberto Catanese, Lena Luisa Semelink-Sedlacek, Sertap Oeztuerk, Anne-Kathrin Lutz, Julia Bausinger, Gotthold Barbi, Günter Speit, Peter M. Andersen, Albert C. Ludolph, Maria Demestre, Tobias M. Boeckers
Publikováno v:
Stem Cell Research, Vol 30, Iss , Pp 150-162 (2018)
Mutations in genes coding for proteins involved in DNA damage response (DDR) and repair, such as C9orf72 and FUS (Fused in Sarcoma), are associated with neurodegenerative diseases and lead to amyotrophic lateral sclerosis (ALS). Heterozygous loss-of-
Externí odkaz:
https://doaj.org/article/be463ac0cbd04cb1b509b67287550dc4
Autor:
Stefanie Pfaender, Karl Föhr, Anne-Kathrin Lutz, Stefan Putz, Kevin Achberger, Leonhard Linta, Stefan Liebau, Tobias M. Boeckers, Andreas M. Grabrucker
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Disturbances in neuronal differentiation and function are an underlying factor of many brain disorders. Zinc homeostasis and signaling are important mediators for a normal brain development and function, given that zinc deficiency was shown to result
Externí odkaz:
https://doaj.org/article/ae6fcb3ac2e34526aebd098301d867d4
Autor:
Moritz Klingenstein, Gotthold Barbi, Anne-Kathrin Huber, Anne-Kathrin Lutz, Albert C. Ludolph, Stefan Putz, Andreas Hermann, Annemarie Huebers, Christian Jacob, Maria Demestre, Julia Bausinger, Tobias M. Boeckers, Günter Speit, Jan Philipp Delling, Julia Higelin, Jochen H. Weishaupt, Stefan Liebau
Publikováno v:
Frontiers in cellular neuroscience 10, 159 (2016). doi:10.3389/fncel.2016.00290
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Mutations within the FUS gene (Fused in Sarcoma) are known to cause Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The FUS gene codes for a multifunctional RNA/DNA-binding protein that is prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7379cbbb27a4ad97f92f4724512a883
Publikováno v:
The EMBO Journal. 31:3038-3062
Neurons are critically dependent on mitochondrial integrity based on specific morphological, biochemical, and physiological features. They are characterized by high rates of metabolic activity and need to respond promptly to activity-dependent fluctu