Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anne-Kathrin Garz"'
Autor:
Brenda A. Schulman, Ulrich Keller, Katharina Götze, Mareike Verbeek, Jacob Stroh, Arne Skerra, Bernhard Kuster, Anna Kuisl, Simone Lemeer, Volker Morath, Michael Heider, Kheewoong Baek, Jana Zecha, Florian Bassermann, Martina Rudelius, Anne-Kathrin Garz, Vanesa Fernández-Sáiz, Johannes Buchner, Ruth Eichner, Wolfgang A. Weber, Jannis Lawatscheck, Friedrich-Christian Deuschle
Publikováno v:
Molecular Cell, 81(6), 1170. Cell Press
Molecular Cell
Molecular Cell
Summary The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication. However, it has remained unclear whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea88a511b9db4500a360c1951b7081c
https://dspace.library.uu.nl/handle/1874/419636
https://dspace.library.uu.nl/handle/1874/419636
Autor:
Marcus Buschbeck, Anne Kathrin Garz, Tomàs Navarro, Jeannine Diesch, Katrina M. Lappin, Andreas Lennartsson, Roberto Malinverni, Raquel Casquero, Johannes Zuber, Ken I. Mills, Anabel Zwick, Anna Palau, Vanesa Valero, Katharina Götze
Publikováno v:
Oncotarget
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Palau, A, Garz, A K, Diesch, J, Zwick, A, Malinverni, R, Valero, V, Lappin, K, Casquero, R, Lennartsson, A, Zuber, J, Navarro, T, Mills, K I, Götze, K S & Buschbeck, M 2017, ' Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes ', Oncotarget, vol. 8, no. 70, pp. 115002-115017 . https://doi.org/10.18632/oncotarget.22839
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Palau, A, Garz, A K, Diesch, J, Zwick, A, Malinverni, R, Valero, V, Lappin, K, Casquero, R, Lennartsson, A, Zuber, J, Navarro, T, Mills, K I, Götze, K S & Buschbeck, M 2017, ' Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes ', Oncotarget, vol. 8, no. 70, pp. 115002-115017 . https://doi.org/10.18632/oncotarget.22839
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
// Anna Palau 1, 2, 6 , Anne-Kathrin Garz 3, 4 , Jeannine Diesch 1 , Anabel Zwick 3 , Roberto Malinverni 1 , Vanesa Valero 1 , Katrina Lappin 5 , Raquel Casquero 1, 2 , Andreas Lennartsson 6 , Johannes Zuber 7 , Tomas Navarro 1, 8 , Ken I. Mills 5 ,
The IMiD-Target Cereblon Determines Transmembrane Protein Quality Control Promoting Tumor Metabolism
Autor:
Vanesa Fernández-Sáiz, Ruth Eichner, Martina Rudelius, Florian Bassermann, Bernhard Kuster, Jannis Lawatscheck, Christian Peschel, Jacob Stroh, Michael Heider, Jana Zecha, Anne-Kathrin Garz, Anna Kuisl, Katharina Götze, Simone Lemeer, Johannes Buchner, Ulrich Keller
Publikováno v:
Blood. 134:314-314
Introduction: Cereblon (CRBN) is the target for immunomodulatory drugs (IMiDs) such as thalidomide and its derivatives lenalidomide and pomalidomide, which are key therapeutics for hematologic malignancies such as multiple myeloma (MM) and del(5q) my
Autor:
Charlotta Pagel, Roberto Malinverni, Sonja Grath, Catharina Wenk, Denis Witham, Christopher B. Mulholland, Michèle Kyncl, Marcus Buschbeck, Klaus H. Metzeler, Marie Weickert, Julia Niggemeyer, Katharina Götze, Judith S. Hecker, Anne-Kathrin Garz, Robert A.J. Oostendorp, Christina Huberle, Catharina Müller-Thomas, Heinrich Leonhardt, Florian Bassermann
Publikováno v:
Blood Advances
Mesenchymal stromal cells (MSCs) are crucial components of the bone marrow (BM) microenvironment essential for regulating self-renewal, survival, and differentiation of hematopoietic stem/progenitor cells (HSPCs) in the stem cell niche. MSCs are func
Autor:
Sebastian Bultmann, Irmela Jeremias, Sylvia Herold, Konstanze Döhner, Verena I. Gaidzik, Sonja Grath, Martina Rudelius, Robert A.J. Oostendorp, Saskia Wolf, Christian Thiede, Stefan Habringer, Anne-Kathrin Garz, Christoph Ziegenhain, Martha Smets, Ulrich Keller, Binje Vick, Marie-Theresa Weickert, Katharina Götze, Christian Peschel
Publikováno v:
Oncotarget
Oncotarget 8, 108738-108759 (2017)
Oncotarget 8, 108738-108759 (2017)
Effectively targeting leukemia-initiating cells (LIC) in FLT3-ITD-mutated acute myeloid leukemia (AML) is crucial for cure. Tyrosine kinase inhibitors (TKI) have limited impact as single agents, failing to eradicate LIC in the bone marrow. Using prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fce7dd889c37633c59bdea52448db5f
https://mediatum.ub.tum.de/1440363
https://mediatum.ub.tum.de/1440363
Autor:
Stefania Re Depaolini, Tõnu Vooder, Paul-Albert Koenig, Jana Zecha, Mathias Wilhelm, Florian Bassermann, Harald Polzer, Tobias Schmidt, Hannes Hahne, Jan Huenges, Judith Schlegl, Axel Walch, Irmela Jeremias, Stephanie Heinzlmeir, Binje Vick, Bernhard Kuster, Bjoern-Oliver Gohlke, Dominic Helm, Karsten Spiekermann, Karl Kramer, Daniel P Zolg, Neeme Tõnisson, Juergen Ruland, Hans-Christian Ehrlich, Annette Feuchtinger, Wilhelm Becker, Benjamin Ruprecht, Katharina Götze, Svenja Petzoldt, Stephan Aiche, Lars Rueckert, Susan Klaeger, Sabine Schneider, Melanie Schoof, Anne-Kathrin Garz, Maria Reinecke, G. Canevari, Eduard R. Felder, Guillaume Médard, Chen Meng, Philipp A. Greif, Gian Kayser, Elena Casale, Zhixiang Wu, Robert Preissner, Heiner Koch, Huichao Qiao, Katrin Reiter
Publikováno v:
Science
Science 358:eaan4368 (2017)
Science 358:eaan4368 (2017)
An atlas for drug interactions Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. There are hundreds of kinases within the human body, so knowing the kinase “
Autor:
Anne-Kathrin Garz, Ulrich Germing, Frauke van Bebber, Martina Rudelius, Katharina Götze, Ruth Eichner, Anna-Maria Knorn, Vanesa Fernández-Sáiz, Bettina Schmid, Christian Haass, H. Einsele, Bernhard Kuster, Christian Peschel, Florian Bassermann, Stefan Knop, Jolanta Slawska, Simone Lemeer, Christian Langer, Bianca-Sabrina Targosz, Ulrich Keller, Laura Jacobs, Uwe Platzbecker, Michael Heider
Publikováno v:
Nature Medicine, 22(7), 735. Nature Publishing Group
Nature medicine 22(7), 735-743 (2016). doi:10.1038/nm.4128
Nature medicine 22(7), 735-743 (2016). doi:10.1038/nm.4128
Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517bd673db89b497ffcf5aa22ade20b5
https://dspace.library.uu.nl/handle/1874/344119
https://dspace.library.uu.nl/handle/1874/344119
Autor:
Jeannine Diesch, Marcus Buschbeck, Katharina Götze, Anne-Kathrin Garz, Anabel Zwick, Anna M. Palau
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Clinical Epigenetics
Universitat Autònoma de Barcelona
Clinical Epigenetics
Altres ajuts: DJCLS/R14/16 Altres ajuts: AFM/18738 Altres ajuts: DFG/FOR2033GO713/2-1 Altres ajuts: DFG/SFB1243 The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921a0a0182afc7d47818422b474ef043
https://ddd.uab.cat/record/174630
https://ddd.uab.cat/record/174630
Autor:
A. Zwick, M. Buschbeck, R. Malinverni, J. Diesch, T. Navarro, Anne-Kathrin Garz, K. Goetze, V. Valero, A. Palau
Publikováno v:
Leukemia Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Autor:
Saskia Wolf, Robert A.J. Oostendorp, Ulrich Keller, Binje Vick, Anne-Kathrin Garz, Katharina Götze, Marie-Theresa Weickert, Christian Peschel, Karsten Spiekermann, Irmela Jeremias, Stefan Habringer
Publikováno v:
Blood. 126:676-676
Background: Effectively targeting the oncogenic mutation FLT3-ITD remains a crucial goal in acute myeloid leukemia (AML) therapy. Thus far, tyrosine kinase inhibitors (TKI) have not been able to eradicate the earliest leukemia-initiating cells (LIC)