Gangliosides do not affect ABC transporter function in human neuroblastoma cells

Autor: Anne-Jan Dijkhuis, Karin Klappe, Willem Kamps, Hannie Sietsma, Jan Willem Kok

Publikováno v: Journal of Lipid Research, Vol 47, Iss 6, Pp 1187-1195 (2006)

Previous studies have indicated a role for glucosylceramide synthase (GCS) in multidrug resistance (MDR), either related to turnover of ceramide (Cer) or generation of gangliosides, which modulate apoptosis and/or the activity of ABC transporters. Th

Externí odkaz: https://doaj.org/article/e0a7a5bf5b004821933ac8b2c8159b41

Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation

Autor: Anne-Jan Dijkhuis, Xiao Yan Qi, Stanley Nattel, Denis Chartier, Lei Ke, Robert H. Henning, Bianca J. J. M. Brundel, Harm H. Kampinga

Publikováno v: Journal of Molecular and Cellular Cardiology, 45(5), 685-693. Academic Press Inc.
Ke, L, Qi, X Y, Dijkhuis, A-J, Chartier, D, Nattel, S, Henning, R H, Kampinga, H H & Brundel, B J M 2008, ' Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation ', Journal of Molecular and Cellular Cardiology, vol. 45, no. 5, pp. 685-693 . https://doi.org/10.1016/j.yjmcc.2008.08.012
Journal of molecular and cellular cardiology, 45(5), 685-693. ELSEVIER SCI LTD

The self-perpetuation of atrial fibrillation (AF) is associated with atrial remodeling, including the degradation of the myofibril structure (myolysis). Myolysis is related to AF-induced activation of cysteine proteases and underlies loss of contract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31b34bc9f0377356d0bd0ebf35f1ef4
https://doi.org/10.1016/j.yjmcc.2008.08.012

PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy

Autor: Hannie Sietsma, Jan Willem Kok, Karin Klappe, Willem Kamps, Susan Jacobs, Anne-Jan Dijkhuis, Bart-Jan Kroesen

Publikováno v: Molecular cancer therapeutics, 5(3), 593-601. AMER ASSOC CANCER RESEARCH

The sphingolipid ceramide has been recognized as an important mediator in the apoptotic machinery, and its efficient conversion to glucosylceramide has been associated with multidrug resistance. Therefore, inhibitors of glucosylceramide synthase are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60d33d1fece525e4c590afac9a131a4
https://doi.org/10.1158/1535-7163.mct-05-0457

Interaction between nitric oxide and subsets of human T lymphocytes with differences in glutathione metabolism

Autor: Anne-Jan Dijkhuis, Jan G.R. de Monchy, Ramon Roozendaal, Henk F. Kauffman, Dirkje S. Postma, Elisabeth T. V. Ommen, Edo Vellenga

Publikováno v: Immunology. 107:334-339

Nitric oxide (NO) modulates human T-lymphocyte responses through several mechanisms. In the current study we show that interactions between NO and glutathione (GSH) metabolism are related to the selective persistent inhibition of interferon-gamma (IF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6513b1cca4a517eca3a5fa032e62ea4
https://doi.org/10.1046/j.1365-2567.2002.01502.x

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Autor: Anne Jan Dijkhuis, Jan Willem Kok, Willem Kamps, Hannie Sietsma

Publikováno v: Neurochemical Research. 27:665-674

Disseminated neuroblastoma usually calls for chemotherapy as the primary approach for treatment. Treatment failure is often attributable to drug resistance. This involves a variety of cellular mechanisms, including increased drug efflux through expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e330886b7726eb58f7295a8f9b70fe23
https://doi.org/10.1023/a:1020228117739