Výsledky vyhledávání - "Anne-Françoise Rochat"

Akademický článek

Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life.

Autor: Elodie Belnoue, Paola Fontannaz, Anne-Françoise Rochat, Chantal Tougne, Andreas Bergthaler, Paul-Henri Lambert, Daniel D Pinschewer, Claire-Anne Siegrist

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e85302 (2013)

Infant mortality from viral infection remains a major global health concern: viruses causing acute infections in immunologically mature hosts often follow a more severe course in early life, with prolonged or persistent viral replication. Similarly,

Externí odkaz: https://doaj.org/article/7e2c1e8b65d647c3abe52c2d8c51b1c4

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Akademický článek

A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells.

Autor: Arun T Kamath, Anne-Françoise Rochat, Dennis Christensen, Else Marie Agger, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e5771 (2009)

BACKGROUND: In the search for more potent and safer tuberculosis vaccines, CAF01 was identified as a remarkable formulation. Based on cationic liposomes and including a synthetic mycobacterial glycolipid as TLR-independent immunomodulator, it induces

Externí odkaz: https://doaj.org/article/295b4053cf684a41be16177746428c33

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Akademický článek

Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant.

Autor: Arun T Kamath, Anne-Françoise Rochat, Mario P Valenti, Else Marie Agger, Karen Lingnau, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist

Publikováno v: PLoS ONE, Vol 3, Iss 11, p e3683 (2008)

BACKGROUND: With the exception of some live vaccines, e.g. BCG, subunit vaccines formulated with "classical" adjuvants do not induce similar responses in neonates as in adults. The usual neonatal profile is characterized by lower levels of TH1-associ

Externí odkaz: https://doaj.org/article/17c59911479c4944a8b06fa054424fb4

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Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche

Autor: Paul-Henri Lambert, Chantal Tougne, Elodie Belnoue, Daniel D. Pinschewer, Anne-Françoise Rochat, Claire-Anne Siegrist

Publikováno v: Journal of Immunology
Journal of Immunology, Vol. 188, No 3 (2012) pp. 1283-91

According to commonly held concepts, plasma cell (PC) longevity in bone marrow (BM) depends upon their access to survival niches. These are thought to exist in nursery cell types, which support PCs by secreting PC survival factors. To better define P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025d4f91a08da481ac28f3c10e77234c

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Environmental and T Cell–Intrinsic Factors Limit the Expansion of Neonatal Follicular T Helper Cells but May Be Circumvented by Specific Adjuvants

Autor: Anne-Françoise Rochat, Paul-Henri Lambert, Fabienne Tacchini-Cottier, Floriane Auderset, Elodie Belnoue, Arun T. Kamath, Béatris Mastelic, Christophe Combescure, Paola Fontannaz, Chantal Tougne, Claire-Anne Siegrist

Publikováno v: J Immunol
Journal of immunology (Baltimore Md. : 1950)
Journal of Immunology, Vol. 189, No 12 (2012) pp. 5764-72

Follicular Th (TFH) cells have emerged as a new Th subset providing help to B cells and supporting their differentiation into long-lived plasma cells or memory B cells. Their differentiation had not yet been investigated following neonatal immunizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a928fe9cebcbb61e4fbd3cc8b17aeb
http://www.jimmunol.org/content/189/12/5764.long

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A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

Autor: Yvonne Perrie, Paul-Henri Lambert, Thomas Lindenstrøm, Else Marie Agger, Karen Smith Korsholm, Peter Andersen, Anne-Françoise Rochat, Arun T. Kamath, Malou Henriksen-Lacey, Claire-Anne Siegrist, Jan Pravsgaard Christensen, Dennis Christensen

Publikováno v: Journal of Controlled Release; Vol 160
Journal of Controlled Release
Journal of Controlled Release, Vol. 160, No 3 (2012) pp. 468-76

Adjuvants are often composed of different constituents that can be divided into two groups based on their primary activity: the delivery system which carries and presents the vaccine antigen to antigen-presenting cells, and the immunostimulator that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d004b1f3b7cd053989697ff54d7dff08

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Synchronization of Dendritic Cell Activation and Antigen Exposure Is Required for the Induction of Th1/Th17 Responses

Autor: Arun T. Kamath, Béatris Mastelic, Paul-Henri Lambert, Else Marie Agger, Peter Andersen, Claire-Anne Siegrist, Dennis Christensen, Daniel D. Pinschewer, Anne-Françoise Rochat

Publikováno v: The Journal of Immunology
The Journal of Immunology; Vol 188
Journal of Immunology, Vol. 188, No 10 (2012) pp. 4828-37

The dendritic cell (DC) targeting/activation patterns required to elicit Th1/Th17 responses remain undefined. One postulated requirement was that of a physical linkage between Ags and immunomodulators. Accordingly, the separate same-site administrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80a4a487e9dded8e8c992230eae5f38

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Protective anti-mycobacterial T cell responses through exquisitein vivo activation of vaccine-targeted dendritic cells

Autor: Anne-Françoise Rochat, Claire-Anne Siegrist, Karen Lingnau, Else Marie Agger, Arun T. Kamath, Paul-Henri Lambert, Mario Paolo Valenti, Alexander von Gabain, Peter Andersen

Publikováno v: European Journal of Immunology, Vol. 38, No 5 (2008) pp. 1247-56

Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c43873d7b578f338fce48c8a5441447
https://doi.org/10.1002/eji.200737889

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Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life

Autor: Claire-Anne Siegrist, Andreas Bergthaler, Chantal Tougne, Anne-Françoise Rochat, Paola Fontannaz, Paul-Henri Lambert, Daniel D. Pinschewer, Elodie Belnoue

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e85302 (2013)
PLOS ONE, Vol. 8, No 12 (2013) P. e85302
PLoS ONE

INFANT MORTALITY FROM VIRAL INFECTION REMAINS A MAJOR GLOBAL HEALTH CONCERN: viruses causing acute infections in immunologically mature hosts often follow a more severe course in early life, with prolonged or persistent viral replication. Similarly,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df30fb04774421d05e69658c9f96b436
http://europepmc.org/articles/PMC3871569?pdf=render

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A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells

Autor: Dennis Christensen, Anne-Françoise Rochat, Peter Andersen, Claire-Anne Siegrist, Arun T. Kamath, Else Marie Agger, Paul-Henri Lambert

Publikováno v: PLoS ONE
PLoS ONE, Vol 4, Iss 6, p e5771 (2009)
PLOS ONE, Vol. 4, No 6 (2009) P. e5771

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d813c4fd3b5e0560b104af5047f94711
https://pubmed.ncbi.nlm.nih.gov/19492047

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