Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anne-Flore Zmoos"'
Autor:
Ursula Ehmer, Anne-Flore Zmoos, Raymond K. Auerbach, Dedeepya Vaka, Atul J. Butte, Mark A. Kay, Julien Sage
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 371-381 (2014)
In mammals, a cell’s decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrol
Externí odkaz:
https://doaj.org/article/4921832d2d8845aaa8244ec664ea8f8f
Publikováno v:
PLoS Genetics, Vol 6, Iss 6, p e1001003 (2010)
The retinoblastoma tumor suppressor (Rb) is a potent and ubiquitously expressed cell cycle regulator, but patients with a germline Rb mutation develop a very specific tumor spectrum. This surprising observation raises the possibility that mechanisms
Externí odkaz:
https://doaj.org/article/c7518aca8498400bafc6bd8807f0feff
Autor:
Julien Sage, Atul J. Butte, Kwon S. Park, Purvesh Khatri, Joel W. Neal, Jonathan W. Riess, Karolina Krasinska, Margaret Zhou, Kim Q.T. Tran, Dedeepya Vaka, Anne-Flore Zmoos, Alec Palmerton, Dian Yang, Natasha Flores, Pawel K. Mazur, Joel T. Dudley, Nadine S. Jahchan
Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with high mortality. We used a systematic drug repositioning bioinformatics approach querying a large compendium of gene expression profiles to identify candidate U.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cd7de55dc05e575ae0a84fb636f5c2
https://doi.org/10.1158/2159-8290.c.6545696.v1
https://doi.org/10.1158/2159-8290.c.6545696.v1
Autor:
Julien Sage, Atul J. Butte, Kwon S. Park, Purvesh Khatri, Joel W. Neal, Jonathan W. Riess, Karolina Krasinska, Margaret Zhou, Kim Q.T. Tran, Dedeepya Vaka, Anne-Flore Zmoos, Alec Palmerton, Dian Yang, Natasha Flores, Pawel K. Mazur, Joel T. Dudley, Nadine S. Jahchan
PDF file 980K, Expression levels of the ligands of the GPCRs targeted by the TCAs and the enzymes required for their biosynthesis in SCLC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7868ccefa643bf338597e320b28671f0
https://doi.org/10.1158/2159-8290.22528334.v1
https://doi.org/10.1158/2159-8290.22528334.v1
Autor:
Julien Sage, Atul J. Butte, Kwon S. Park, Purvesh Khatri, Joel W. Neal, Jonathan W. Riess, Karolina Krasinska, Margaret Zhou, Kim Q.T. Tran, Dedeepya Vaka, Anne-Flore Zmoos, Alec Palmerton, Dian Yang, Natasha Flores, Pawel K. Mazur, Joel T. Dudley, Nadine S. Jahchan
PDF file 94K, Top 100 FDA-approved drugs identified by a bioinformatics drug- repositioning approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37bee1b3666da6756fee53b7b9e7326
https://doi.org/10.1158/2159-8290.22528325
https://doi.org/10.1158/2159-8290.22528325
Autor:
Julien Sage, Atul J. Butte, Kwon S. Park, Purvesh Khatri, Joel W. Neal, Jonathan W. Riess, Karolina Krasinska, Margaret Zhou, Kim Q.T. Tran, Dedeepya Vaka, Anne-Flore Zmoos, Alec Palmerton, Dian Yang, Natasha Flores, Pawel K. Mazur, Joel T. Dudley, Nadine S. Jahchan
PDF file 114K, This document provides detailed information on some of the methods employed in our manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4926573609d4024c5fcf53b8f1b76291
https://doi.org/10.1158/2159-8290.22528328.v1
https://doi.org/10.1158/2159-8290.22528328.v1
Autor:
Eric K. Hubner, C Lechler, Julien Sage, Anne-Flore Zmoos, B Kohnke-Ertel, Roland M. Schmid, Ursula Ehmer
Publikováno v:
J Gene Med
Background Hydrodynamic tail vein injection (HTVI) of transposon-based integration vectors is an established system for stably transfecting mouse hepatocytes in vivo that has been successfully employed to study key questions in liver biology and canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cafbfbc1ffe9635e409e17882d3041
https://europepmc.org/articles/PMC9481923/
https://europepmc.org/articles/PMC9481923/
Autor:
Jakob Ogrodnik, Anne-Flore Zmoos, Elise Balse, Stephan E. Lehnart, Hugues Abriel, Stéphane N. Hatem, Stefan Luther, Alain Coulombe, Philip Bittihn, Said El-Haou, Séverine Petitprez, Nour Raad, Maxime Albesa
Publikováno v:
Circulation Research; Vol 108
Rationale: The cardiac sodium channel Na v 1.5 plays a key role in excitability and conduction. The 3 last residues of Na v 1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin–dystrophin complex. As dystrophin
Autor:
Glenn S. Van Aller, Peter J. Tummino, BaoChau Le, Gloria Mas, Roland S. Annan, Ryan G. Kruger, Patrick McDevitt, Nicolas Reynoird, Olena Barbash, Michael J. Huddleston, Or Gozani, Julien Sage, Shichong Liu, Benjamin A. Garcia, Robert H. Sinnamon, Anne-Flore Zmoos
Publikováno v:
Epigenetics
Epigenetics, Taylor & Francis, 2014, 7 (4), pp.340-343. ⟨10.4161/epi.19506⟩
Epigenetics, Taylor & Francis, 2014, 7 (4), pp.340-343. ⟨10.4161/epi.19506⟩
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a29467a44d30ceee528cd26dfdecafa
https://hal.archives-ouvertes.fr/hal-02989821
https://hal.archives-ouvertes.fr/hal-02989821
Autor:
Nadine Jahchan, Anne-Flore Zmoos, Michael Snyder, Arun Rangaswami, Florette K. Hazard, Julien Sage, Phillip M. Garfin, Lei Xu, Hassan Chaib
Publikováno v:
Human molecular genetics. 24(1)
Pediatric tumors are relatively infrequent, but are often associated with significant lethality and lifelong morbidity. A major goal of pediatric cancer research has been to identify key drivers of tumorigenesis to eventually develop targeted therapi