Extravasation of biodegradable microspheres in the rat brain

Autor: Anne-Eva van der Wijk, Theodosia Georgakopoulou, Rob Steendam, Johan Zuidema, Peter L. Hordijk, Erik N.T.P. Bakker, Ed van Bavel

Publikováno v: Drug Delivery, Vol 30, Iss 1 (2023)

AbstractDrug development for neurological diseases is greatly impeded by the presence of the blood-brain barrier (BBB). We and others previously reported on extravasation of micrometer-sized particles from the cerebral microcirculation – across the

Externí odkaz: https://doaj.org/article/964217b972054fc4925a86e5830a37c9

Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Autor: Anne-Eva van der Wijk, Theodosia Georgakopoulou, Jisca Majolée, Jan S. M. van Bezu, Miesje M. van der Stoel, Bert J. van het Hof, Helga E. de Vries, Stephan Huveneers, Peter L. Hordijk, Erik N. T. P. Bakker, Ed van Bavel

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)

Abstract Considering its intolerance to ischemia, it is of critical importance for the brain to efficiently process microvascular occlusions and maintain tissue perfusion. In addition to collateral microvascular flow and enzymatic degradation of embo

Externí odkaz: https://doaj.org/article/41264de83db645b6a72d2179d05993f2

Quantitative 3D analysis of tissue damage in a rat model of microembolization

Autor: Anushree Dwivedi, Francesco Migliavacca, Simon F. De Meyer, Nerea Arrarte Terreros, Vanessa Blanc-Guillemaud, Stephen J. Payne, Ed van Bavel, Sarah Vandelanotte, Tamás I. Józsa, Ray McCarthy, Praneeta R Konduri, Gabriele Dubini, Jose Felix Rodriguez Matas, Aad van der Lugt, H.F. Lingsma, Diederik W.J. Dippel, Raymond M. Padmos, Ybwem (Yvo) Roos, Bastien Chopard, Henk A. Marquering, Ed VanBavel, A. M. Shibeko, Giulia Luraghi, Patrick Mc Garry, Mikhail A. Panteleev, Sissy Georgakopoulou, Sara Bridio, Kevin M. Moerman, Sharon Duffy, Michael Gilvarry, Charles B. L. M. Majoie, Victor Azizi, Noor Samuels, Franck Raynaud, Nikki Boodt, Remy Petkantchin, Senna Staessens, Theodosia Georgakopoulou, Claire Miller, Karim Zouaoui Boudjeltia, Max van der Kolk, Behrooz Fereidoonnezhad, Erik N. T. P. Bakker, Alfons G. Hoekstra, Anne Eva van der Wijk

Publikováno v: Journal of biomechanics, 128:110723. Elsevier Limited
Journal of Biomechanics, 128:110723. Elsevier Ltd.
Journal of Biomechanics, 128:110723. Elsevier
Journal of Biomechanics, 128:110723. Elsevier Limited
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ORCID
Microsoft Academic Graph

There is a discrepancy between successful recanalization and good clinical outcome after endovascular treatment (EVT) in acute ischemic stroke patients. During removal of a thrombus, a shower of microemboli may release and lodge to the distal circula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb0da97e38e7e5b511ea60b581bbb48
https://pure.amc.nl/en/publications/quantitative-3d-analysis-of-tissue-damage-in-a-rat-model-of-microembolization(ed81f25c-d747-4f7c-af72-e57e02b9d863).html

Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Autor: Stephan Huveneers, Theodosia Georgakopoulou, Jan van Bezu, Miesje M. van der Stoel, Helga E. de Vries, Anne Eva van der Wijk, Erik N. T. P. Bakker, Peter L. Hordijk, Jisca Majolée, Ed van Bavel, Bert van het Hof

Publikováno v: van der Wijk, A E, Georgakopoulou, T, Majolée, J, van Bezu, J S M, van der Stoel, M M, van het Hof, B J, de Vries, H E, Huveneers, S, Hordijk, P L, Bakker, E N T P & van Bavel, E 2020, ' Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain ', Acta neuropathologica communications, vol. 8, no. 1, 195 . https://doi.org/10.1186/s40478-020-01071-9
Acta Neuropathologica Communications
Acta neuropathologica communications, 8(1):195. BioMed Central
PubMed Central
NARCIS
DOAJ-Articles
OpenAIRE
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)

Considering its intolerance to ischemia, it is of critical importance for the brain to efficiently process microvascular occlusions and maintain tissue perfusion. In addition to collateral microvascular flow and enzymatic degradation of emboli, the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b4997368462c1fa2eb173ae80da3ea
https://research.vumc.nl/en/publications/cb116583-4fa5-41be-825d-9a62347cc160

Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood–retinal barrier

Autor: Cornelis J.F. Van Noorden, Rutger P. van Heijningen, Ingeborg Klaassen, Anne-Eva van der Wijk, Paul Canning, Ilse M. C. Vogels, Reinier O. Schlingemann

Publikováno v: van der Wijk, A-E, Canning, P, van Heijningen, R P, Vogels, I M C, van Noorden, C J F, Klaassen, I & Schlingemann, R O 2019, ' Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood–retinal barrier ', Acta Ophthalmologica, vol. 97, no. 2, pp. 214-224 . https://doi.org/10.1111/aos.13909
Acta ophthalmologica, 97(2), 214-224. Copenhagen Scriptor
Acta Ophthalmologica, 97(2), 214-224. Wiley-Blackwell

Purpose: Glucocorticoids (GCs) are used as treatment in diabetic macular oedema, a condition caused by blood–retinal barrier (BRB) disruption. The proposed mechanisms by which GCs reduce macular oedema are indirect anti-inflammatory effects and inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4e75fded8f12d2bfc8ea49fc677ae0
https://doi.org/10.1111/aos.13909