A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Autor: Anne-Elisabeth Petit, Nathalie Demotte, Benoît Scheid, Claude Wildmann, René Bigirimana, Monica Gordon-Alonso, Javier Carrasco, Salvatore Valitutti, Danièle Godelaine, Pierre van der Bruggen

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion,

Externí odkaz: https://doaj.org/article/3477da4108d44f4daa43367177312336

An International Consensus List of Potentially Clinically Significant Drug-Drug Interactions in Older People

Autor: Nicolas Rodondi, Axel Lennart Löwe, Denis O'Mahony, Aðalsteinn Gudmundsson, Antonio Cherubini, Roy L. Soiza, Anne-Elisabeth Petit, Bastiaan T.G.M. Sallevelt, Olivia Dalleur, Clara Drenth, Anne Spinewine, Isabelle De Brauwer, Kieran Dalton, Silvan Thürig, Agapios Panos, Jamie J Coleman, Dimitris Mavridis, Pauline Anrys, Mirko Petrovic, Andrea Correa-Pérez, Stefanie Thevelin

Publikováno v: Journal of the American Medical Directors Association
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Journal of the American Medical Directors Association, Vol. 22, no. 10, p. 2121-2133.e24 (2021)

Objectives We aimed to establish an explicit list of potentially clinically significant drug-drug interactions (DDIs) in people aged ≥65 years. Design A preliminary list of potentially clinically significant DDIs was compiled, based on 154 DDIs ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e3c1a6970f3a74ef8e87f260c5f52f
https://hdl.handle.net/10641/2570

Activation of the Ancestral Polarity Regulator Protein Kinase Cζ at the Immunological Synapse Drives Polarization of Th Cell Secretory Machinery toward APCs

Autor: Magda Rodrigues, Florie Bertrand, Jérôme Delon, Anne-Elisabeth Petit, Sophie Duchez, Salvatore Valitutti, Michael Esquerre

Publikováno v: The Journal of Immunology. 185:2887-2894

A key feature in T lymphocyte biology is that Th cells rapidly polarize their secretory machinery toward cognate APCs. The molecular mechanisms of these dynamic Th cell responses and their impact on APC biology remain to be elucidated. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a33cc6d2e5a4fae1530534c2e87eba7
https://doi.org/10.4049/jimmunol.1000739