Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Anne-Christine Uldry"'
Autor:
Déborah Mathis, Jasmine Koch, Sophie Koller, Kay Sauter, Christa Flück, Anne-Christine Uldry, Patrick Forny, D. Sean Froese, Alexander Laemmle
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 39, Iss , Pp 101066- (2024)
Mitochondrial malate dehydrogenase 2 (MDH2) is crucial to cellular energy generation through direct participation in the tricarboxylic acid (TCA) cycle and the malate aspartate shuttle (MAS). Inherited MDH2 deficiency is an ultra-rare metabolic disea
Externí odkaz:
https://doaj.org/article/56cf900502d140459292f6c91fed6cfd
Autor:
Akshay Akshay, Ali Hashemi Gheinani, Mustafa Besic, Sophie Braga, Anne-Christine Uldry, Manfred Heller, Hubert Rehrauer, Catharine Aquino Fournier, Fiona C. Burkhard, Katia Monastyrskaya
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-20 (2024)
Abstract Background Benign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable urodynamic alterations in bladder function.
Externí odkaz:
https://doaj.org/article/826487d262f84fa4bc3d06907ba659cc
Autor:
Joachim Müller, Ghalia Boubaker, Norbert Müller, Anne-Christine Uldry, Sophie Braga-Lagache, Manfred Heller, Andrew Hemphill
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6903 (2024)
Identification of drug targets and biochemical investigations on mechanisms of action are major issues in modern drug development. The present article is a critical review of the classical “one drug”—“one target” paradigm. In fact, novel me
Externí odkaz:
https://doaj.org/article/41f5aa8b01e94ed9b1d47e8e3532f780
Autor:
Livia Spörri, Anne-Christine Uldry, Marco Kreuzer, Elio L. Herzog, Martin S. Zinkernagel, Jan D. Unterlauft, Denise C. Zysset-Burri
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6257 (2024)
Although glaucoma is a leading cause of irreversible blindness worldwide, its pathogenesis is incompletely understood, and intraocular pressure (IOP) is the only modifiable risk factor to target the disease. Several associations between the gut micro
Externí odkaz:
https://doaj.org/article/8470a9edab8747c091bb14b814c11cd3
Autor:
Roman Memedovski, Matías Preza, Joachim Müller, Tobias Kämpfer, Reto Rufener, Marcus Vinicius Nora de Souza, Emerson Teixeira da Silva, Gabriel Fernandes de Andrade, Sophie Braga, Anne-Christine Uldry, Natasha Buchs, Manfred Heller, Britta Lundström-Stadelmann
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 114-124 (2023)
Alveolar echinococcosis (AE) is caused by infection with the fox tapeworm E. multilocularis. The disease affects humans, dogs, captive monkeys, and other mammals, and it is caused by the metacestode stage of the parasite growing invasively in the liv
Externí odkaz:
https://doaj.org/article/89a49aeeca2f46a99fa3bbefacf831fb
Autor:
Joachim Müller, Carling Schlange, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Richard K. Haynes, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 1-12 (2023)
The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the pero
Externí odkaz:
https://doaj.org/article/ab6fe9874f28493880edaf6ef7fc235c
Autor:
Lukas-Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philipp Couttet, Frederic Sigoillot, Jana Ziegelmüller, Anne-Christine Uldry, Wojciech Teodorowicz, Niko Schmiedeberg, Oliver Mühlemann, Jürgen Reinhardt
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113159- (2023)
Externí odkaz:
https://doaj.org/article/a17f69f34eb64c599e2fdcd86f226d38
Autor:
Jubilee Ajiboye, Anne-Christine Uldry, Manfred Heller, Arunasalam Naguleswaran, Erkang Fan, Wesley C. Van Voorhis, Andrew Hemphill, Joachim Müller
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2707 (2024)
Cryptosporidium parvum is an apicomplexan parasite causing persistent diarrhea in humans and animals. Issuing from target-based drug development, calcium-dependent protein kinase 1 inhibitors, collectively named bumped kinase inhibitors (BKIs), with
Externí odkaz:
https://doaj.org/article/8df75ba9ccbf4172b9656ac9ebce67df
Autor:
Joachim Müller, Matías Preza, Marc Kaethner, Reto Rufener, Sophie Braga, Anne-Christine Uldry, Manfred Heller, Britta Lundström-Stadelmann
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The larval stage of the cestode Echinococcus multilocularis is the causative agent of alveolar echinococcosis. To investigate the biology of these stages and to test novel compounds, metacestode cultures represent a suitable in vitro model system. Th
Externí odkaz:
https://doaj.org/article/7424e9620f4041edb08887ce551f8b69
Autor:
Kai Pascal Alexander Hänggeli, Andrew Hemphill, Norbert Müller, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Joachim Müller, Ghalia Boubaker
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10454 (2023)
In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a suitable tool to identify the role of specific genes. The general consensus implies that only the gene of interest is affected by the knock-out. Is this really t
Externí odkaz:
https://doaj.org/article/ba16f7ca331549b4b4fc3de477bc1ccb