Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anne-Christin Lamerz"'
Autor:
Anne-Christin Lamerz, Barbara Kleczka, Jens Lamerz, Martin Wiese, Sebastian Damerow, Stephen M. Beverley, Fong-Fu Hsu, Alexander Wenzel, Ger van Zandbergen, Françoise H. Routier, John Turk
Publikováno v:
Glycobiology. 20:872-882
The nucleotide sugar UDP-galactose (UDP-Gal) is essential for the biosynthesis of several abundant glycoconjugates forming the surface glycocalyx of the protozoan parasite Leishmania major. Current data suggest that UDP-Gal could arise de novo by epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12843c8a6c3c922f739c62fc0e573aec
https://doi.org/10.1093/glycob/cwq045
https://doi.org/10.1093/glycob/cwq045
Autor:
Sebastian Damerow, Thomas Haselhorst, Françoise H. Routier, Mark von Itzstein, Anne-Christin Lamerz, Jana Führing, Patricia Zarnovican
Publikováno v:
Journal of Biological Chemistry. 285:878-887
The Leishmania parasite glycocalyx is rich in galactose-containing glycoconjugates that are synthesized by specific glycosyltransferases that use UDP-galactose as a glycosyl donor. UDP-galactose biosynthesis is thought to be predominantly a de novo p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfebf6dddcc43ac2928283e62bbd46f5
https://doi.org/10.1074/jbc.m109.067223
https://doi.org/10.1074/jbc.m109.067223
Autor:
Gleb Bourenkov, Thomas Steiner, Stephan Krapp, Rita Gerardy-Schahn, Robert Huber, Petra Hess, Uwe Jacob, Anne-Christin Lamerz, Constanze Breithaupt
Publikováno v:
Journal of Biological Chemistry. 282:13003-13010
Uridine diphosphate-glucose pyrophosphorylase (UGPase) represents a ubiquitous enzyme, which catalyzes the formation of UDP-glucose, a key metabolite of the carbohydrate pathways of all organisms. In the protozoan parasite Leishmania major, which cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2486ea4b2b6e8c2e57aa7baa14bc63
https://doi.org/10.1074/jbc.m609984200
https://doi.org/10.1074/jbc.m609984200
Catalytic Mechanism and Allosteric Regulation of UDP-Glucose Pyrophosphorylase from Leishmania major
Autor:
Rita Gerardy-Schahn, Anne-Christin Lamerz, Jana Führing, Johannes T. Cramer, P. Baruch, Françoise H. Routier, Roman Fedorov
Publikováno v:
ACS catalysis 3(12), 2976-2985 (2013). doi:10.1021/cs4007777
UDP-glucose pyrophosphorylase (UGP) is a nucleotidyltransferase of central importance in all organisms and considered an attractive drug target in the human pathogens Leishmania and Trypanosoma. He...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ce681bc88de15604b2ea1269b273e7
https://bib-pubdb1.desy.de/record/168320
https://bib-pubdb1.desy.de/record/168320
Autor:
Anne-Christin Lamerz, Sebastian Damerow, Achim Dickmanns, Françoise H. Routier, Piotr Neumann, Eike C. Schulz, Ralf Ficner
Publikováno v:
Journal of molecular biology. 405(2)
Nucleotide sugars and the enzymes that are responsible for their synthesis are indispensable for the production of complex carbohydrates and, thus, for elaboration of a protective cellular coat for many organisms such as the protozoan parasite Leishm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95f4221f857ff5d08db324878c42ddd
https://pubmed.ncbi.nlm.nih.gov/21073876
https://pubmed.ncbi.nlm.nih.gov/21073876
Autor:
Sebastian, Damerow, Anne-Christin, Lamerz, Thomas, Haselhorst, Jana, Führing, Patricia, Zarnovican, Mark, von Itzstein, Françoise H, Routier
Publikováno v:
The Journal of biological chemistry. 285(2)
The Leishmania parasite glycocalyx is rich in galactose-containing glycoconjugates that are synthesized by specific glycosyltransferases that use UDP-galactose as a glycosyl donor. UDP-galactose biosynthesis is thought to be predominantly a de novo p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41e22b5da798b438b591a78912e73f1b
https://pubmed.ncbi.nlm.nih.gov/19906649
https://pubmed.ncbi.nlm.nih.gov/19906649
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 534
Saturation transfer difference (STD) Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful method for studying protein-ligand interactions in solution. The STD NMR method is capable of identifying the binding epitope of a ligand when bound to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab91c1951cb1de57b99c402bd49ae865
https://pubmed.ncbi.nlm.nih.gov/19277538
https://pubmed.ncbi.nlm.nih.gov/19277538
Publikováno v:
Glycomics ISBN: 9781588297747
Saturation transfer difference (STD) Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful method for studying protein-ligand interactions in solution. The STD NMR method is capable of identifying the binding epitope of a ligand when bound to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a24fd99342c2381c5c018173d343ca95
https://doi.org/10.1007/978-1-59745-022-5_26
https://doi.org/10.1007/978-1-59745-022-5_26
Autor:
Françoise H. Routier, Martin Wiese, Rita Gerardy-Schahn, Ger van Zandbergen, Barbara Kleczka, Alexander Wenzel, Anne-Christin Lamerz
Publikováno v:
The Journal of biological chemistry. 282(14)
Considering the high incidence of galactofuranose (Gal(f)) in pathogens and its absence from higher eukaryotes, the enzymes involved in the biosynthesis of this unusual monosaccharide appear as attractive drug targets. However, although the importanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abecf2ad38ce8dfc328d9f7d3950556b
https://pubmed.ncbi.nlm.nih.gov/17284446
https://pubmed.ncbi.nlm.nih.gov/17284446
Autor:
Ann Bergfeld, Mark von Itzstein, Thomas Haselhorst, Anne-Christin Lamerz, Rita Gerardy-Schahn
Publikováno v:
The Journal of biological chemistry. 281(24)
The dense glycocalyx surrounding the protozoan parasite Leishmania is an essential virulence factor. It protects the parasite from hostile environments in the sandfly vector and mammalian host and supports steps of development and invasion. Therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d96b4f96d03994e72535efd5100c204
https://pubmed.ncbi.nlm.nih.gov/16611637
https://pubmed.ncbi.nlm.nih.gov/16611637