GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

Autor: Anne-Catherine Maurin, Laurent Parry, Wafa B’chir, Valérie Carraro, Cécile Coudy-Gandilhon, Ghita Chaouki, Cédric Chaveroux, Sylvie Mordier, Brigitte Martinie, Vanessa Reinhardt, Céline Jousse, Alain Bruhat, Patrice Codogno, Julien Averous, Pierre Fafournoux

Publikováno v: Autophagy Reports, Vol 1, Iss 1, Pp 119-142 (2022)

The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations. Our previous results d

Externí odkaz: https://doaj.org/article/be1aa155eac94e5eaacf0757451823ad

Hypothalamic eIF2α Signaling Regulates Food Intake

Autor: Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, Valérie Carraro, Christophe Guissard, Julien Averous, Céline Jousse, Alain Bruhat, Cédric Chaveroux, Wafa B’chir, Yuki Muranishi, David Ron, Luc Pénicaud, Pierre Fafournoux

Publikováno v: Cell Reports, Vol 6, Iss 3, Pp 438-444 (2014)

The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a highly conserved signal implicated in the cellular adaptation to numerous stresses such as the one caused by amino acid limitation. In response to dietar

Externí odkaz: https://doaj.org/article/2ce376b4b55e420095cd6256dc033a52

Perinatal protein malnutrition affects mitochondrial function in adult and results in a resistance to high fat diet-induced obesity.

Autor: Céline Jousse, Yuki Muranishi, Laurent Parry, Christophe Montaurier, Patrick Even, Jean-Marie Launay, Valérie Carraro, Anne-Catherine Maurin, Julien Averous, Cédric Chaveroux, Alain Bruhat, Jacques Mallet, Béatrice Morio, Pierre Fafournoux

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104896 (2014)

Epidemiological findings indicate that transient environmental influences during perinatal life, especially nutrition, may have deleterious heritable health effects lasting for the entire life. Indeed, the fetal organism develops specific adaptations

Externí odkaz: https://doaj.org/article/a6f689220521470abc4e3b7c94a1911f

A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization

Autor: Ola Habanjar, Anne-Catherine Maurin, Cyrielle Vituret, Caroline Vachias, Lucie Longechamp, Cécile Garnier, Caroline Decombat, Céline Bourgne, Mona Diab-Assaf, Florence Caldefie-Chezet, Laetitia Delort

Publikováno v: Biomaterials Science
Biomaterials Science, 2023, 11 (9), pp.3308-3320. ⟨10.1039/d2bm01470j⟩

International audience; Recently, many types of 3D culture systems have been developed to preserve the physicochemical environment and biological characteristics of the original tumors better than the conventional 2D monolayer culture system. There a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17a877979c7165e7bb200a1031df082
https://uca.hal.science/hal-04103734

Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears

Autor: Laura Cussonneau, Cécile Coudy-Gandilhon, Christiane Deval, Ghita Chaouki, Mehdi Djelloul-Mazouz, Yoann Delorme, Julien Hermet, Guillemette Gauquelin-Koch, Cécile Polge, Daniel Taillandier, Julien Averous, Alain Bruhat, Céline Jousse, Isabelle Papet, Fabrice Bertile, Etienne Lefai, Pierre Fafournoux, Anne-Catherine Maurin, Lydie Combaret

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2023, 24 (1), pp.621. ⟨10.3390/ijms24010621⟩
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 621

Activating transcription factor 4 (ATF4) is involved in muscle atrophy through the overexpression of some atrogenes. However, it also controls the transcription of genes involved in muscle homeostasis maintenance. Here, we explored the effect of ATF4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924380c6f4c3795bbb69be25b1d5ec4b
https://pubmed.ncbi.nlm.nih.gov/36614063