Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency

Autor: Léa Broca-Brisson, Rania Harati, Clémence Disdier, Orsolya Mozner, Romane Gaston-Breton, Auriane Maïza, Narciso Costa, Anne-Cécile Guyot, Balazs Sarkadi, Agota Apati, Matthew R Skelton, Lucie Madrange, Frank Yates, Jean Armengaud, Rifat Hamoudi, Aloïse Mabondzo

Publikováno v: eLife, Vol 12 (2023)

Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the SLC6A8 gene. The impaired creatine uptake in the brain results in intellectual disability, behavioral disorders, language delay, and seizures. In this work, we ge

Externí odkaz: https://doaj.org/article/e52897c931c1438dbf89ad9807783b44

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes.

Autor: Serena Pavoni, Rafika Jarray, Ferid Nassor, Anne-Cécile Guyot, Steve Cottin, Jessica Rontard, Jacqueline Mikol, Aloïse Mabondzo, Jean-Philippe Deslys, Frank Yates

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0209150 (2018)

Human mini-brains (MB) are cerebral organoids that recapitulate in part the complexity of the human brain in a unique three-dimensional in vitro model, yielding discrete brain regions reminiscent of the cerebral cortex. Specific proteins linked to ne

Externí odkaz: https://doaj.org/article/42b286926f5245ecbb4e3f4752714fc2

Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model

Autor: Anne-Cécile Guyot, Serena Pavoni, Frank Yates, Oliver Langer, Jean-Philippe Deslys, Frédéric Théodoro, Yulia Kiyan, Narciso Costa, Ferid Nassor, Gwenaëlle Le Roux, Nicolas Tournier, Rafika Jarray, Alain Pruvost, Aloïse Mabondzo

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-52213-6⟩
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-52213-6⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

The development of effective central nervous system (CNS) drugs has been hampered by the lack of robust strategies to mimic the blood-brain barrier (BBB) and cerebrovascular impairments in vitro. Recent technological advancements in BBB modeling usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb16988a6ae818e7a0879fa6072eb58
https://hal.inrae.fr/hal-02981983

In vitro primary human and animal cell-based blood-brain barrier models as a screening tool in drug discovery

Autor: Aloïse Mabondzo, Anne-Cécile Guyot, Sandrine Blondel, Christelle Contreras, Alain Pruvost, Orianne Videau, Henri Benech, Lucie Krzaczkowski, Laurence Nicolas, Aurélie Ghettas, Colette Prevost, Olivier Lacombe, Delphine Chevillon, Sébastien Bolze, Etienne A. Thévenot

Publikováno v: Molecular pharmaceutics. 8(3)

Brain penetration is characterized by its extent and rate and is influenced by drug physicochemical properties, plasma exposure, plasma and brain protein binding and BBB permeability. This raises questions related to physiology, interspecies differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f32e43098a5d77fb38789686018221
https://pubmed.ncbi.nlm.nih.gov/21438632

Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice

Autor: Amie K. Lund, Lindsay M. Herbert, JoAnn Lucero, Aloïse Mabondzo, Anne-Cécile Guyot, Hannah A Oppenheim, Jacob D. McDonald

Publikováno v: Oppenheim, Hannah A; Lucero, JoAnn; Guyot, Anne-Cécile; Herbert, Lindsay M; McDonald, Jacob D; Mabondzo, Aloïse; et al.(2013). Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Particle and Fibre Toxicology, 10(1), 62. doi: http://dx.doi.org/10.1186/1743-8977-10-62. Retrieved from: http://www.escholarship.org/uc/item/4df2d02j
Particle and Fibre Toxicology

Background Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ce59596f90521d110368c75aec7670