Molecular Profiling of Druggable Targets in Clear Cell Renal Cell Carcinoma Through Targeted RNA Sequencing

Autor: Corina N. A. M. van den Heuvel, Anne van Ewijk, Carolien Zeelen, Tessa de Bitter, Martijn Huynen, Peter Mulders, Egbert Oosterwijk, William P. J. Leenders

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Clear cell renal cell carcinoma (ccRCC) comprises more than 80% of all renal cancers and when metastasized leads to a 5-year survival rate of only 10%. The high rate of therapy failure and resistance development calls for reliable methods that provid

Externí odkaz: https://doaj.org/article/baa389584cb04ee5bf5eb047d1df4487

Isocitrate dehydrogenase 1–mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

Autor: Corina N. A. M. van den Heuvel, Arend Heerschap, Kiek Verrijp, Wiljan Hendriks, Paul N. Span, Martijn A. Huynen, Cornelis J.F. Van Noorden, Mohammed Khurshed, Krissie Lenting, Benno Küsters, Remco J. Molenaar, Tom H Peeters, Anne van Ewijk, William P.J. Leenders, Mark ter Laan, Tessa J. J. de Bitter, Sanne A. M. van Lith, Dennis Botman

Publikováno v: FASEB journal, 33(1), 557-571. FASEB
The Faseb Journal, 33, 1, pp. 557-571
The Faseb Journal, 33, 557-571

Contains fulltext : 202248.pdf (Publisher’s version ) (Closed access) Diffuse gliomas often carry point mutations in isocitrate dehydrogenase ( IDH1(mut)), resulting in metabolic stress. Although IDH(mut) gliomas are difficult to culture in vitro,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceead8f02b0693701aab7b561ae8f82
https://doi.org/10.1096/fj.201800907rr

Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing

Autor: Mark ter Laan, Elizabeth Tindall, Maarten te Dorsthorst, Ge Wei, Martijn A. Huynen, Duaa Elmelik, Benno Küsters, Remco de Boer, William P.J. Leenders, Anne van Ewijk, Krissie Lenting, Corina N. A. M. van den Heuvel

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Acta Neuropathologica Communications, 7, 185
Acta Neuropathologica Communications, 7, 1, pp. 185
Acta Neuropathologica Communications

Contains fulltext : 214227.pdf (Publisher’s version ) (Open Access) Many biology-based precision drugs are available that neutralize aberrant molecular pathways in cancer. Molecular heterogeneity and the lack of reliable companion diagnostic biomar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133bc99d673d3ede2a029dc9a533cd2f
https://hdl.handle.net/2066/214227