Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anne de Brugerolle de Fraissinette"'
Publikováno v:
Toxicology in Vitro. 24:1379-1385
At its 25th meeting the ECVAM Scientific Advisory Committee (ESAC) unanimously endorsed that the SkinEthic Reconstructed Human Epidermis (RHE) model could be used for distinguishing between corrosive and non-corrosive chemicals within the context of
Autor:
Marie-Hélène Grandidier, Sophie Loisel-Joubert, Anne-Marie Minondo, Carolle Amsellem, José Cotovio, Damien Lelièvre, Christophe Capallere, Jacques Leclaire, Estelle Tinois-Tessonneaud, Béatrice Bertino, Anne De Brugerolle de Fraissinette, Saber Maloug, Christelle Bremond, Jean-Marc Ovigne, Nathalie Alépée, Jean-Roch Meunier, Aline Van Der Lee
Publikováno v:
Toxicology in Vitro. 24:523-537
The 7th amendment of the EU Cosmetics Directive led to the ban of eye irritation testing for cosmetic ingredients in animals, effective from March 11th 2009. Over the last 20 years, many efforts have been made to find reliable and relevant alternativ
Publikováno v:
Toxicology in Vitro. 24:245-256
The development of in vitro protocols able to discriminate skin irritants from non-irritants integrates the toxicologists' needs for reliable and robust in vitro tools for screening test substances. Based on EpiSkin test method, validated by ESAC (EC
Autor:
Peter Nussbaumer, Beate Vogel, Anne de Brugerolle de Fraissinette, Jesús Medina, Anthony Winiski, Josef G. Meingassner, Brigitte Greiner, Danielle Roman, Maryelle Kolopp, Christian Elsaesser, Valerie Picarles, Andreas Mahl
Publikováno v:
Biochemical Pharmacology. 66:1885-1895
The skin tolerability of the tubulin polymerisation inhibitor LAV694 was compared to that of 5% 5-fluorouracil (5-FU) and 0.5% podophyllotoxin in vitro using a human reconstructed epidermis (HRE), and in vivo using minipigs. Topical treatment of HRE
Autor:
Pascale Burtin, Anne de Brugerolle de Fraissinette, Salah-Dine Chibout, Marie-Eve Ebelin, Jesús Medina, André Cordier, Maryelle Kolopp, Rahel Kammermann
Publikováno v:
Toxicology and Applied Pharmacology. 164:38-45
The main goal of the present study was to investigate the response of the human skin equivalent Apligraf in vitro to the application of irritant substances and its predictivity as a screening tool for cumulative skin irritant potential in humans. Vas
Autor:
Stephen Molloy, Jesús Medina, Anne de Brugerolle de Fraissinette, Olivier Grenet, Nicole Hartmann, Valerie Picarles, Salah-Dine Chibout, André Cordier
Publikováno v:
Archives of Dermatological Research. 295:269-271
calcipotriol, binds to the nu-clear vitamin D receptor and acts as a transcription factor.The result is inhibition of keratinocyte proliferation andpromotion of cell differentiation [2, 3]. New compoundsacting on this pathway, with improved pharmacol
Autor:
Olivier Doucet, Jean Pachot, Cécile Robert, Carole Amsellem, Marisa Meloni, Nathalie Alépée, Anne de Brugerolle de Fraissinette, Marie-Hélène Roux, Carine Tornier
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 24(1)
Efforts to fully replace the in vivo Draize skin irritation test, according to the Directive 67/548/ECC or OECD TG 404, were reinforced with the seventh Amendment of the Cosmetic Directive and the REACh regulation. In 2007, the EpiSkin test method wa
Autor:
Martin Rosdy, Anne de Brugerolle de Fraissinette, Alix Gazel, Miroslav Blumenberg, Carine Tornier
Publikováno v:
Journal of cellular physiology. 217(3)
Nickel is a ubiquitous and virtually unavoidable environmental pollutant and occupational hazard, but its molecular and cellular effects are not well understood. Human epidermal keratinocytes are the sentinel and the primary target for nickel. We tre
Autor:
Maryelle Kolopp, Jesús Medina, Valerie Picarles, Salah-Dine Chibout, Anne de Brugerolle de Fraissinette, Christian Elsaesser, Olivier Grenet
Publikováno v:
In vitromolecular toxicology. 14(3)
The goal of this study was to design a model system for the assessment of phototoxic potential using a human reconstructed epidermis (HRE, SkinEthic Laboratories, Nice, France), by testing some representative phototoxic (P) and non-phototoxic (NP) co
Autor:
Anne de Brugerolle de Fraissinette, Jesús Medina, Danielle Roman, Willie Suter, Maria Bobadilla, Elisa Garcia Garayoa
Publikováno v:
Journal of Dermatological Science. 16:S80