Hazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays

Autor: Anne Zwartsen, Michiel E. Olijhoek, Remco H. S. Westerink, Laura Hondebrink

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Synthetic cathinones are the second largest class of new psychoactive substances (NPS) on the drug market. Despite the large number of different cathinones and their abundant use, hazard characterization is mainly limited to their potential to inhibi

Externí odkaz: https://doaj.org/article/c5258db486c54915a2a735957627173a

Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

Autor: Esther de Jong, Hilko van der Voet, Philip Marx‐Stoelting, Susanne Hougaard Bennekou, Corinne Sprong, Denise Bloch, Alina Burchardt, Alexandra Lasch, Tobias Opialla, Stefanie Rotter, Eva Bay Wedebye, Anne Zwartsen, Anke Leys, Maryam Zare Jeddi, Gerrit Wolterink, Johannes Kruisselbrink, Waldo de Boer, Jacob van Klaveren

Publikováno v: EFSA Supporting Publications, 19(10)
EFSA Supporting Publications 19 (2022) 10

EFSA's aim by 2030, is that the Agency and its partners will be equipped for the routine implementation of human health risk assessment to multiple chemicals, across EFSA's domains of activity. To facilitate this effort, a roadmap for action has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0358dba7593d5ff211b4e2abd96cb22b
https://doi.org/10.2903/sp.efsa.2022.en-7555

Flotillins in the intercalated disc are potential modulators of cardiac excitability

Autor: Anne Zwartsen, Carol Ann Remme, Igor R. Efimov, Teun P. de Boer, Antje Banning, Marc A. Vos, Alex V. Postma, Joanne J.A. van Bavel, Leonie van Stuijvenberg, Toon A.B. van Veen, Mathilde R. Rivaud, Aryan Vink, Elise L. Kessler, Ritva Tikkanen, Joelle van Bennekom, J. Peter van Tintelen

Publikováno v: Journal of Molecular and Cellular Cardiology, 126, 86. Academic Press Inc.
Journal of molecular and cellular cardiology, 126, 86-95. Academic Press Inc.

Background The intercalated disc (ID) is important for cardiac remodeling and has become a subject of intensive research efforts. However, as yet the composition of the ID has still not been conclusively resolved and the role of many proteins identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17dba8e48eb60e54d1c2d85223c2540
https://doi.org/10.1016/j.yjmcc.2018.11.007

Evaluation of anti-tumour properties of two depsidones – Unguinol and Aspergillusidone D – in triple-negative MDA-MB-231 breast tumour cells

Autor: M.B.M. van Duursen, M. van den Berg, Mathuros Ruchirawat, Anne Zwartsen, Suthat Chottanapund, Prasat Kittakoop, Panida Navasumrit

Publikováno v: Toxicology Reports, 6, 1216. Elsevier Scientific Publishers Ireland
Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 1216-1222 (2019)

Highlights • Unguinol and Aspergillusidone D inhibit cell viability at low μM concentrations. • These depsidones increase the amount of apoptotic cells in the MDA-MB-231 cell line. • Unguinol causes cell cycle arrest of MDA-MB-231 cells in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66da52a9f083db7146711573f60550b7
https://doi.org/10.1016/j.toxrep.2019.10.012