Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Anne W Schmidt"'
Autor:
Stephen Jenkinson, Jonathan Gallion, Darren Cawkill, Brigitte Murat, Olivier Lichtarge, Yong Ren, Michel Bouvier, Karim Nagi, Emma T van der Westhuizen, Christian Le Gouill, Besma Benredjem, Viktoryia Lukasheva, Johanie Charbonneau, Paul Dallaire, Mark Gosink, Anne W. Schmidt, Christopher Somps, Dennis J. Pelletier, Graciela Piñeyro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors should be specifically activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57762958730e340da6b5d5094174a386
https://doaj.org/article/c0db3f1cf110426bbd5f35d40fd3681b
https://doaj.org/article/c0db3f1cf110426bbd5f35d40fd3681b
Autor:
Kimberly F. Fennell, Zhijun Kang, Hirokazu Ueno, William E. Hoffman, Mihály Hajós, Thomas Allen Chappie, Mary Piotrowski, Noha Maklad, Jayvardhan Pandit, John M. Humphrey, Anne W. Schmidt, Edward X. Yang, Patrick Robert Verhoest, Bethany L. Kormos, Jiemin Lu, Eric P. Arnold, Cheng Chang, Christopher J. Schmidt, Robin J. Kleiman, Rebecca E. O’Connor, John F. Harms, Scot Richard Mente, Christopher John Helal, Tracey Boyden, Chewah Lee, Laura McDowell, Michael D. Forman
Publikováno v:
Journal of Medicinal Chemistry. 60:5673-5698
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify potent PDE2A inhibitors with improved brain pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146c156bc1785305e9a93e6cd8b6147
https://doi.org/10.1021/acs.jmedchem.7b00397
https://doi.org/10.1021/acs.jmedchem.7b00397
Autor:
Beata Planeta, Shu-fei Lin, Aarti Sawant-Basak, Jean-Dominique Gallezot, Donna Palumbo, Richard E. Carson, Jing Liu, Carolyn Rowinski, Yiyun Huang, Nabeel Nabulsi, David Labaree, Kristin Chidsey, Xiaoxi Li, Timothy J. McCarthy, Jim Ropchan, Anne W. Schmidt
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:1095-1107
Measurements of drug occupancies using positron emission tomography (PET) can be biased if the radioligand concentration exceeds “tracer” levels. Negative bias would also arise in successive PET scans if clearance of the radioligand is slow, resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86812448f2c9d31331398daec220cb9d
https://doi.org/10.1177/0271678x16650697
https://doi.org/10.1177/0271678x16650697
Autor:
Yiyun Huang, David Labaree, Aarti Sawant-Basak, Nabeel Nabulsi, Jean-Dominique Gallezot, Donna Palumbo, Laigao Chen, Douglas K. Spracklin, Anne W. Schmidt, Elaine E. Tseng, Timothy J. McCarthy, Christopher L. Shaffer, Richard E. Carson
Publikováno v:
Xenobiotica. 47:119-126
1. Unbound brain drug concentration (Cb,u), a valid surrogate of interstitial fluid drug concentration (CISF), cannot be directly determined in humans, which limits accurately defining the human Cb,u:Cp,u of investigational molecules. 2. For the H3R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23743ffeeabebda6e538afe126e90b33
https://doi.org/10.3109/00498254.2016.1166531
https://doi.org/10.3109/00498254.2016.1166531
Autor:
Christopher Somps, Brigitte Murat, Jonathan Gallion, Yong Ren, Christian Le Gouill, Michel Bouvier, Dennis J. Pelletier, Stephen Jenkinson, Johanie Charbonneau, Paul Dallaire, Graciela Piñeyro, Olivier Lichtarge, Viktoryia Lukasheva, Karim Nagi, Anne W. Schmidt, Besma Benredjem, Darren Cawkill, Emma T van der Westhuizen, Mark Gosink
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6f932be7876350843df5d208fb9552
https://doaj.org/article/1f09235de66f4fc295108bc582f6d396
https://doaj.org/article/1f09235de66f4fc295108bc582f6d396
Autor:
Christopher J. Helal, Eric P. Arnold, Tracey L. Boyden, Cheng Chang, Thomas A. Chappie, Kimberly F. Fennell, Michael D. Forman, Mihaly Hajos, John F. Harms, William E. Hoffman, John M. Humphrey, Zhijun Kang, Robin J. Kleiman, Bethany L. Kormos, Erik A. LaChapelle, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E. O’Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W. Schmidt, Christopher J. Schmidt, Hirokazu Ueno, Patrick R. Verhoest, Edward X. Yang
Publikováno v:
Journal of medicinal chemistry. 61(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284ec23899d97800205ac23dc80d4562
https://pubmed.ncbi.nlm.nih.gov/28574706
https://pubmed.ncbi.nlm.nih.gov/28574706
Autor:
Jean-Dominique, Gallezot, Beata, Planeta, Nabeel, Nabulsi, Donna, Palumbo, Xiaoxi, Li, Jing, Liu, Carolyn, Rowinski, Kristin, Chidsey, David, Labaree, Jim, Ropchan, Shu-Fei, Lin, Aarti, Sawant-Basak, Timothy J, McCarthy, Anne W, Schmidt, Yiyun, Huang, Richard E, Carson
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 37(3)
Measurements of drug occupancies using positron emission tomography (PET) can be biased if the radioligand concentration exceeds “tracer” levels. Negative bias would also arise in successive PET scans if clearance of the radioligand is slow, resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::925ab6556f84b11baf5c7c5d4afa573f
https://pubmed.ncbi.nlm.nih.gov/27207170
https://pubmed.ncbi.nlm.nih.gov/27207170
Autor:
Alexandros Papanikolaou, Elaine E. Tseng, Noguchi Hirohide, Michael Aaron Brodney, Michelle Vanase-Frawley, Laura McDowell, Nobuaki Waizumi, Katherine Fisher, Aarti Sawant-Basak, Betty Pettersen, Elena M. Drummond, David M. Rubitski, Anne W. Schmidt, Kim Jonelle Stutzman-Engwall, David E. Johnson, Emily L. Hudson, Sarah Grimwood, Karen J. Coffman
Publikováno v:
Journal of Medicinal Chemistry. 55:9240-9254
The cognitive impairments observed in Alzheimer’s disease (AD) are in part a consequence of reduced acetylcholine (ACh) levels resulting from a loss of cholinergic neurons. Preclinically, serotonin 4 receptor (5-HT4) agonists are reported to modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d51b0b91e9707931c753f01d83b2c9f
https://doi.org/10.1021/jm300953p
https://doi.org/10.1021/jm300953p
Autor:
Michelle Vanase-Frawley, Diane Stephenson, Patrick Robert Verhoest, Mihály Hajós, Geralyn P. Kocan, William E. Hoffmann, Kari R. Fonseca, Douglas S. Chapin, Christopher J. Schmidt, Fredrick R. Nelson, Curt Christoffersen, Frank S. Menniti, Jody Freeman, Stafford McLean, Victor Guanowsky, Kieran F. Geoghegan, Mark J. Majchrzak, Christopher John Helal, Patricia A. Seymour, John F. Harms, Sarah Grimwood, Francis David Tingley, Robin J. Kleiman, Robin Roof, Anne W. Schmidt, Dina McGinnis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 341:396-409
Cyclic nucleotides are critical regulators of synaptic plasticity and participate in requisite signaling cascades implicated across multiple neurotransmitter systems. Phosphodiesterase 9A (PDE9A) is a high-affinity, cGMP-specific enzyme widely expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e434253f25e37a0d7e9a05a69e8cdd81
https://doi.org/10.1124/jpet.111.191353
https://doi.org/10.1124/jpet.111.191353
Autor:
Rama Y. Chandrasekaran, Jiri Aubrecht, Frederick R. Nelson, Linda A. Chatman, Hans Rollema, Frank M. Nedza, John M. Marcek, Philip A. Iredale, Jennifer B. Munzner, Betty Pettersen, Raggon Jeffrey W, David M. Rubitski, Julie Cianfrogna, Larry C. James, Karen W. Cook, Michael J. Banker, Diane F. Wong, Anne W. Schmidt, Michael Homiski, Howard Harry R, Daniel J. Lettiere, Butler Todd W, Scot Richard Mente, Jody Freeman, Travis T. Wager, Douglas K. Spracklin
Publikováno v:
Journal of Medicinal Chemistry. 54:7602-7620
The discovery of two histamine H3 antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c253ef2a0b55c8bf1f6522eccc0c6ed
https://doi.org/10.1021/jm200939b
https://doi.org/10.1021/jm200939b