Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Anne V. Thomas"'
Autor:
Christa J. Maynard, Bradley T. Hyman, Nico P. Dantuma, Hilkka Soininen, Anne V. Thomas, Claudia Böttcher, Jayashree Viswanathan, Kaisa M.A. Kurkinen, Lars Bertram, Alice Lu, Rudolph E. Tanzi, Mikko Hiltunen, Annakaisa Haapasalo, Oksana Berezovska, Donna M. Romano, Riitta Miettinen
Publikováno v:
Traffic. 12:330-348
The Alzheimer's disease (AD)-associated ubiquilin-1 regulates proteasomal degradation of proteins, including presenilin (PS). PS-dependent γ-secretase generates β-amyloid (Aβ) peptides, which excessively accumulate in AD brain. Here, we have chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407bafe41212902ced09109ef2411626
https://doi.org/10.1111/j.1600-0854.2010.01149.x
https://doi.org/10.1111/j.1600-0854.2010.01149.x
Autor:
Christina M. Lill, Anne V. Thomas, Bradley T. Hyman, Oksana Berezovska, Lauren Herl, Phill Jones, Mary Banks, Amy Deng, Robert Spoelgen
Publikováno v:
Molecular and Cellular Neuroscience. 41:166-174
Alzheimer's disease is characterized by accumulation of toxic beta-amyloid (Abeta) in the brain and neuronal death. Several mutations in presenilin (PS1) and beta-amyloid precursor protein (APP) associate with an increased Abeta(42/40) ratio. Abeta(4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390b56ef91c237974014857c7f49f00e
https://doi.org/10.1016/j.mcn.2009.02.008
https://doi.org/10.1016/j.mcn.2009.02.008
Autor:
Andreas H. Jacobs, Michael T. Heneka, Markus Schubert, Yannic Waerzeggers, Alexandra Winkeler, Anke Klose, Parisa Monfared, Anne V. Thomas
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Introduction Molecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110f87255144c89df51e88105e25a01e
https://doi.org/10.1007/s00259-007-0710-0
https://doi.org/10.1007/s00259-007-0710-0
Autor:
Anne V. Thomas, Dudley K. Strickland, Christine A F Von Arnim, Ithan D. Peltan, Bradley T. Hyman, Irina Mikhailenko
Publikováno v:
Biochemical and Biophysical Research Communications. 349:24-30
The low-density lipoprotein receptor-related protein (LRP) is a large, endocytic receptor involved in intracellular signalling. LRP acts as a co-receptor with the PDGF-receptor (PDGF-r) for platelet-derived growth factor (PDGF). PDGF-r and Src-kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96ce329414ff468993023fc48d5d9c4
https://doi.org/10.1016/j.bbrc.2006.07.212
https://doi.org/10.1016/j.bbrc.2006.07.212
Autor:
Bradley T. Hyman, Rudolph E. Tanzi, Lauren Herl, Phill Jones, Oksana Berezovska, Anne V. Thomas, Mikko Hiltunen, Robert Spoelgen
Publikováno v:
Journal of Biological Chemistry. 281:26400-26407
Presenilin 1 (PS1) in its active heterodimeric form is the catalytic center of the gamma-secretase complex, an enzymatic activity that cleaves amyloid precursor protein (APP) to produce amyloid beta (Abeta). Ubiquilin 1 is a recently described PS1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e877f55711a1d6317b19e88d4b5548
https://doi.org/10.1074/jbc.m601085200
https://doi.org/10.1074/jbc.m601085200
Autor:
H F Petereit, Anke Brockhaus-Dumke, Wolf-Dieter Heiss, Johannes C. Klein, Andreas H. Jacobs, Anne V. Thomas
Publikováno v:
Der Nervenarzt. 77:711-715
Die fatale familiare Insomnie (FFI) ist eine vererbbare Prionenerkrankung, die durch eine Mutation im Codon 178 des Prionproteingens (PRNP) auf Chromosom 20 verursacht wird. Die Erkrankung ist durch gestorten Nachtschlaf und hieraus resultierende Vig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71602b084013998cb41931c2a829cd1
https://doi.org/10.1007/s00115-006-2073-3
https://doi.org/10.1007/s00115-006-2073-3
Autor:
Lauren Herl, Andrew C. Nyborg, Alberto Lleó, Karen Jansen, Oksana Berezovska, Anne V. Thomas, Bradley T. Hyman, Todd E. Golde
Publikováno v:
Biochemical and Biophysical Research Communications. 340:668-674
Presenilin-1 (PS1) is a multipass transmembrane domain protein, which is believed to be the catalytic component of the gamma-secretase complex. The complex is comprised of four major components: PS1, nicastrin, Aph-1, and Pen-2. The exact stoichiomet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c430fdd35ca9ecb87538d99e3f37fe7a
https://doi.org/10.1016/j.bbrc.2005.12.063
https://doi.org/10.1016/j.bbrc.2005.12.063
Publikováno v:
Journal of Neurology. 253:258-260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27ac5995d645905a019153d6fc813761
https://doi.org/10.1007/s00415-005-0953-2
https://doi.org/10.1007/s00415-005-0953-2
Autor:
Anne V. Thomas, Edward T. C. Spooner
Publikováno v:
Geochimica et Cosmochimica Acta. 56:49-65
Gas Chromatographic analyses, using ~105°C heated, on-line crushing as the release system, and photoionization (PID) and micro-thermal conductivity (TCD) detectors, of 17 samples (~2 g) in duplicate from three zones of the Tanco granitic pegmatite,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fafba1e9cc7240c079d910ec72a30e66
https://doi.org/10.1016/0016-7037(92)90116-z
https://doi.org/10.1016/0016-7037(92)90116-z
Publikováno v:
Neuroimmunomodulation. 16(6)
Objectives: Treatment with interferon(IFN) β, glatiramer acetate (GLAT) and intravenous immunoglobulins (IVIG) alters the cytokine production in multiple sclerosis (MS) patients. To date, it is not clear whether the effect on cytokines varies among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68635245fc2ee7e0c15b2026e3999cc
https://pubmed.ncbi.nlm.nih.gov/19609087
https://pubmed.ncbi.nlm.nih.gov/19609087