B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Autor: Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes

Externí odkaz: https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Autor: Urs Mörbe, Rita Pinter, Mariagrazia Uguccioni, Charles J.N. Lacey, Mark Coles, Marcus Thelen, Mark C. Leake, Zhaoukun Zhou, Natalia Pikor, Jason Cosgrove, Tom Cupedo, Anne Thuery, Jens V. Stein, Jon Timmis, Jovana Cupovic, Stefan Albrecht, Manfred Heller, Bénédicte Manoury, Kieran Alden, Mario Novkovic, Daniel F. Legler, Helen Miller, Burkhard Ludewig, Wojciech G. Polak, Marlene Wolf, Andrew Coatesworth, Daniel Venetz, Lucas Onder, Emily Taylor, Peter O'Toole, Simon Jarrett

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Cosgrove, Jason; Novkovic, Mario; Albrecht, Stefan; Pikor, Natalia B; Zhou, Zhaoukun; Onder, Lucas; Mörbe, Urs; Cupovic, Jovana; Miller, Helen; Alden, Kieran; Thuery, Anne; O'Toole, Peter; Pinter, Rita; Jarrett, Simon; Taylor, Emily; Venetz, Daniel; Heller, Manfred; Uguccioni, Mariagrazia; Legler, Daniel F; Lacey, Charles J; ... (2020). B cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nature Communications, 11(1), p. 3677. Springer Nature 10.1038/s41467-020-17135-2
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, ⟨10.1038/s41467-020-17135-2⟩
Nature Communications, 11(1):3677. Nature Publishing Group

Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues. Here we show that the chemokine CXCL13 forms both soluble and immobilized gradients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19f1429b70eaa59b0f8dc6a47b8f22d
http://link.springer.com/article/10.1038/s41467-020-17135-2

Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets

Autor: Christine Henninger, Anne Thuery, Olivier Bonny, Simon Wöhrle, Noemie Beluch, Francesco Hofmann, Vito Guagnano, Nancy E. Hynes, William R. Sellers, Diana Graus Porta, Michaela Kneissel

Publikováno v: Journal of Bone and Mineral Research. 28:899-911

Fibroblast growth factor 23 (FGF23) is a circulating factor secreted by osteocytes that is essential for phosphate homeostasis. In kidney proximal tubular cells FGF23 inhibits phosphate reabsorption and leads to decreased synthesis and enhanced catab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cba602604b612631d593c013836d02b
https://doi.org/10.1002/jbmr.1810

Fibroblast Growth Factor Receptors as Novel Therapeutic Targets in SNF5-Deleted Malignant Rhabdoid Tumors

Autor: Charles W. M. Roberts, Flavia Reimann, Simon Wöhrle, Audrey Kauffmann, Thomas Brümmendorf, Masato Murakami, Vito Guagnano, Andreas Weiss, Zainab Jagani, Astrid Pornon, Beatrice Bauer-Probst, Vincent Romanet, Christelle Stamm, Moriko Ito, William R. Sellers, Francesco Hofmann, Diana Graus Porta, Anne Thuery

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e77652 (2013)

Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1. MRTs are poorly responsive to chemotherapy and thus a high unmet clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709652f4af067c6b5632a2a9e96a3944
https://doi.org/10.1371/journal.pone.0077652