Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

Autor: Bryan M. Dunyak, Jungsoon Lee, Mark R. Wilson, Harindranath Kadavath, Victoria A. Assimon, Francis T.F. Tsai, Olivier Julien, Chad A. Dickey, Jennifer N. Rauch, Markus Zweckstetter, Rebecca Freilich, Sue-Ann Mok, Anne T. Gillies, Jason E. Gestwicki, Carlo Condello, Javier Oroz, Taylor Arhar

Publikováno v: Nature structural & molecular biology
Nature Structural and Molecular Biology
Nature structural & molecular biology 25(5), 384-393 (2018). doi:10.1038/s41594-018-0057-1
Nature structural & molecular biology, vol 25, iss 5

A network of molecular chaperones is known to bind proteins (“clients”) and balance their folding, function and turnover. However, it is often not clear which chaperones are critical for selective recognition of individual clients. It is also not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3599a70c0b3cd7e1a62eb1d691ffda3f
http://europepmc.org/articles/PMC5942583

15N NMR Studies of a Nitrile-Modified Nucleoside

Autor: Beth L. Buckwalter, Anne T. Gillies, Xin Sonia Gai, Edward E. Fenlon, Scott H. Brewer

Publikováno v: The Journal of Physical Chemistry B. 114:17136-17141

Nitrile-modified molecules have proven to be excellent probes of local environments in biomolecules via both vibrational and fluorescence spectroscopy. The utility of the nitrile group as a spectroscopic probe has been expanded here to (15)N NMR spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451b2a62859975c2088ae9a39d25b276
https://doi.org/10.1021/jp106493t

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

Autor: Anne T. Gillies, Joseph Liu, Jason E. Gestwicki, Laura J. Blair, Dave Morgan, Steven B. Housley, Hayk Davtyan, Daniel C. Lee, Marcia N. Gordon, Bryce A. Nordhues, Chad A. Dickey, Maj Linda B. Selenica, Bo Zhang

Publikováno v: Journal of Neuroinflammation

Background Abnormal tau hyperphosphorylation and its accumulation into intra-neuronal neurofibrillary tangles are linked to neurodegeneration in Alzheimer’s disease and similar tauopathies. One strategy to reduce accumulation is through immunizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cd98f9e0ed05b718eec18994f787e2
https://doi.org/10.1186/s12974-014-0152-0

Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones

Autor: Jason E. Gestwicki, Anne T. Gillies, Rebecca Taylor

Publikováno v: Molecular bioSystems, vol 8, iss 11

J proteins are a diverse family of co-chaperones that cooperate with heat shock protein 70 (Hsp70) to coordinate protein quality control, especially in response to cellular stress. Current models suggest that individual J proteins might play roles in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920e13caa0c8aef94706d6c8618a0a34
https://pubmed.ncbi.nlm.nih.gov/22851130

Nitrile-Modified Nucleosides as a Probe of Local Nucleic Acid Environments

Autor: Xin Gai, Edward E. Fenlon, Anne T. Gillies, Scott H. Brewer, Matthew D. Watson

Publikováno v: Biophysical Journal. 96:313a

The nitrile functional group has been extensively investigated as a probe in proteins but not as a probe in nucleosides. The solvent-induced vibrational frequency shift of the nitrile band of 5-cyano-2′-deoxyuridine was examined in THF-H2O mixtures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4345c78a9e418211d40053558f21d4d5
https://doi.org/10.1016/j.bpj.2008.12.1563