Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.

Autor: Béatrice Jacquelin, Gaël Petitjean, Désirée Kunkel, Anne-Sophie Liovat, Simon P Jochems, Kenneth A Rogers, Mickaël J Ploquin, Yoann Madec, Françoise Barré-Sinoussi, Nathalie Dereuddre-Bosquet, Pierre Lebon, Roger Le Grand, François Villinger, Michaela Müller-Trutwin

Publikováno v: PLoS Pathogens, Vol 10, Iss 7, p e1004241 (2014)

Chronic immune activation (IA) is considered as the driving force of CD4(+) T cell depletion and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of SIV, such as African green monkeys (AGMs). Here we investigated

Externí odkaz: https://doaj.org/article/fa8de60be3134b30aff1786ab24f2a00

Plasmacytoid Dendritic Cell Infection and Sensing Capacity during Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infection

Autor: Beatrice Jacquelin, Alice Lepelley, Pierre Lebon, Steven E. Bosinger, Simon P. Jochems, Lise Chauveau, Mickaël J.-Y. Ploquin, Gaël Petitjean, Olivier Schwartz, Anne-Sophie Liovat, Michaela Müller-Trutwin, Nicolas Huot, Françoise Barré-Sinoussi, Emily K. Cartwright, Guido Silvestri

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2015, 89 (13), pp.6918-27. ⟨10.1128/JVI.00332-15⟩
Journal of Virology, American Society for Microbiology, 2015, 89 (13), pp.6918-27
Journal of Virology, 2015, 89 (13), pp.6918-27. ⟨10.1128/JVI.00332-15⟩

Human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques (MAC) lead to chronic inflammation and AIDS. Natural hosts, such as African green monkeys (AGM) and sooty mangabeys (SM), are protected against SIV-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edb7695af1b57e752ab6942f5a22f3f
https://doi.org/10.1128/jvi.00332-15

African Non Human Primates Infected by SIV - Why Dont they Get Sick? Lessons from Studies on the Early Phase of Non-Pathogenic SIV Infection

Autor: Beatrice Jacquelin, Anne-Sophie Liovat, Françoise Barré-Sinoussi, Mickaël J.-Y. Ploquin, Michaela Müller-Trutwin

Publikováno v: Current HIV Research
Current HIV Research, Bentham Science Publishers, 2009, 7 (1), pp.39-50. ⟨10.2174/157016209787048546⟩
Current HIV Research, 2009, 7 (1), pp.39-50. ⟨10.2174/157016209787048546⟩

International audience; African non human primates are natural hosts of SIV. The infection is generally non-pathogenic despite high steady-state levels of plasma viral RNA that in HIV-1 and SIVmac infections are associated with progression towards AI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45777896904e2c51500606b2af9ce305
https://doi.org/10.2174/157016209787048546

Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or Not with Interferon-Alpha during Primary SIVagm Infection

Autor: Françoise Barré-Sinoussi, Roger Le Grand, Michaela Müller-Trutwin, Pierre Lebon, Désirée Kunkel, Kenneth A. Rogers, Simon P. Jochems, Beatrice Jacquelin, Francois Villinger, Gaël Petitjean, Anne-Sophie Liovat, Yoann Madec, Mickaël J.-Y. Ploquin, Nathalie Dereuddre-Bosquet

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2014, 10 (7), pp.e1004241. ⟨10.1371/journal.ppat.1004241⟩
PLoS Pathogens, 2014, 10 (7), pp.e1004241. ⟨10.1371/journal.ppat.1004241⟩
PLoS Pathogens, Vol 10, Iss 7, p e1004241 (2014)

Chronic immune activation (IA) is considered as the driving force of CD4+ T cell depletion and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of SIV, such as African green monkeys (AGMs). Here we investigated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb9babce34cc208478f7335cf321f1d
https://hal-pasteur.archives-ouvertes.fr/pasteur-01960800/file/ppat.1004241.pdf

Level of double negative T cells, which produce TGF-β and IL-10, predicts CD8 T-cell activation in primary HIV-1 infection

Autor: Laurence Weiss, Michaela Müller-Trutwin, Maria Elena Manea, Céline Didier, Gaël Petitjean, Anne-Sophie Liovat, Daniel Scott-Algara, Feriel Tibaoui, Pierre-Marie Girard, Laurence Meyer, Françoise Barré-Sinoussi, Mathieu F. Chevalier, Pauline Campa

Publikováno v: AIDS. Official journal of the international AIDS Society
AIDS. Official journal of the international AIDS Society, 2012, 26 (2), pp.139-148. ⟨10.1097/QAD.0b013e32834e1484⟩
AIDS
AIDS, Lippincott, Williams & Wilkins, 2012, 26 (2), pp.139-148. ⟨10.1097/QAD.0b013e32834e1484⟩

International audience; OBJECTIVE:Persistent immune activation plays a central role in the pathogenesis of HIV disease. Besides natural regulatory T cells (nTregs), 'double negative' T cells shown to exhibit regulatory properties could be involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62abd70daaa7192afcadea4ac47bdfed
https://hal-pasteur.archives-ouvertes.fr/pasteur-02006421