Výsledky vyhledávání - "Anne Sophie Carlo"

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

Autor: Thomas E. Willnow, Eleonora Aronica, Antonino Asaro, Magda Bakun, Michal Dadlez, Tymon Rubel, Rishabhdev Sinha, Annemieke Rozeboom, Oleksandra Kalnytska, Bozena Kaminska, Anna R. Malik, Anne-Sophie Carlo-Spiewok

Publikováno v: Asaro, A, Sinha, R, Bakun, M, Kalnytska, O, Carlo-Spiewok, A S, Rubel, T, Rozeboom, A, Dadlez, M, Kaminska, B, Aronica, E, Malik, A R & Willnow, T E 2021, ' ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling ', Journal of Cell Science, vol. 134, no. 20, jcs258894 . https://doi.org/10.1242/jcs.258894
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science, 134(20):jcs258894. Company of Biologists Ltd

Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739701e960bdc03a27e0a11ff57d9c5b
https://pure.au.dk/ws/files/273913024/jcs258894.pdf

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Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

Autor: Antonino Asaro, Joerg Heeren, Thomas E. Willnow, Oliver Peters, Anne-Sophie Carlo-Spiewok, Michael Rothe, Carola G. Schipke, Anna R. Malik

Publikováno v: Asaro, A, Carlo-Spiewok, A-S, Malik, A R, Rothe, M, Schipke, C G, Peters, O, Heeren, J & Willnow, T E 2020, ' Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling ', Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 16, no. 9, pp. 1248-1258 . https://doi.org/10.1002/alz.12121
Alzheimer's and dementia 16(9), 1248-1258 (2020). doi:10.1002/alz.12121

INTRODUCTIONApoE is a carrier for brain lipids and the most important genetic risk factor for Alzheimer’s disease (AD). ApoE binds the receptor sortilin which mediates uptake of apoE-bound cargo into neurons. The significance of this uptake route f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9f366d18c18c60415907d0840e76a4
https://pure.au.dk/portal/da/publications/apolipoprotein-e4-disrupts-the-neuroprotective-action-of-sortilin-in-neuronal-lipid-metabolism-and-endocannabinoid-signaling(3eab6895-ace1-4c85-9e04-b34207a00d19).html

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Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1

Publikováno v: Nature neuroscience
Nature Neuroscience
Nat. Neurosci. 20, 1096-1103 (2017)
Nature neuroscience, 20(8), 1096-1103. Nature Publishing Group
Nature neuroscience, Vol. 20, No 8 (2017) pp. 1096-1103
Rathjen, T, Yan, X, Kononenko, N L, Ku, M-C, Song, K, Ferrarese, L, Tarallo, V, Puchkov, D, Kochlamazashvili, G, Brachs, S, Varela, L, Szigeti-Buck, K, Yi, C-X, Schriever, S C, Tattikota, S G, Carlo, A S, Moroni, M, Siemens, J, Heuser, A, van der Weyden, L, Birkenfeld, A L, Niendorf, T, Poulet, J F A, Horvath, T L, Tschöp, M H, Heinig, M, Trajkovski, M, Haucke, V & Poy, M N 2017, ' Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1 ', Nature Neuroscience, vol. 20, no. 8, pp. 1096-1103 . https://doi.org/10.1038/nn.4590

Susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis. Genome-wide association studies have identified associations between body mass index and two loci near cell adhesion mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b367621004e2f620bfe7fda4a58125a9
https://pubmed.ncbi.nlm.nih.gov/28628102

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Apolipoprotein E receptor pathways in Alzheimer disease

Autor: Thomas E. Willnow, Vanessa Schmidt, Anne-Sophie Carlo

Publikováno v: WIREs Systems Biology and Medicine. 6:255-270

Alzheimer disease (AD) is the most common neurodegenerative disease affecting millions of patients worldwide. According to the amyloid cascade hypothesis, the formation of neurotoxic oligomers composed of amyloid-β (Aβ) peptides is the main mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cabdde2a5ee686c585d012377017e40
https://doi.org/10.1002/wsbm.1262

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Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases

Autor: Matthias Endres, Helmut Kettenmann, Anika Langenfurth, Vincent Prinz, Volker Siffrin, Anne-Sophie Carlo, Rainer Glass, Susanne A. Wolf, Jan Leo Rinnenthal, Frank L. Heppner, Susann Peaschke, Christine Stadelmann, Katyayni Vinnakota

Publikováno v: Journal of Neuroscience Research. 92:275-286

We previously reported that glioma cells induce the expression of membrane-type 1 metalloproteinase (MT1-MMP or MMP-14) in tumor-associated microglia/macrophages and promote tumor growth, whereas MMP-14 expression in microglia under physiological con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70c8643d4249da99a74dddf67b5ff320
https://doi.org/10.1002/jnr.23288

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SORLA-Dependent and -Independent Functions for PACS1 in Control of Amyloidogenic Processes

Autor: Anne-Sophie Carlo, Tilman Burgert, Thomas E. Willnow, Anders Nykjaer, Annette Füchtbauer, Safak Caglayan, Ernst-Martin Füchtbauer, Vanessa Schmidt, Fuyu Lin

Publikováno v: Burgert, T, Schmidt, V, Caglayan, S, Lin, F, Füchtbauer, A, Füchtbauer, E-M, Nykjaer, A, Carlo, A-S & Willnow, T E 2013, ' SORLA-Dependent and-Independent Functions for PACS1 in Control of Amyloidogenic Processes ', Molecular and Cellular Biology, vol. 33, no. 21, pp. 4308-4320 . https://doi.org/10.1128/MCB.00628-13

Sorting-related receptor with A-type repeats (SORLA) is a sorting receptor for the amyloid precursor protein (APP) that prevents breakdown of APP into Aβ peptides, a hallmark of Alzheimer's disease (AD). Several cytosolic adaptors have been shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d87f68cc420e97750da48e2d1161ab
https://doi.org/10.1128/mcb.00628-13

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Lysosomal Sorting of Amyloid-β by the SORLA Receptor Is Impaired by a Familial Alzheimer’s Disease Mutation

Autor: Vanessa Schmidt, Junichi Takagi, Thomas E. Willnow, Ernst-Martin Füchtbauer, Annette Füchtbauer, Fan Liao, Tilman Burgert, Safak Caglayan, Shizuka Takagi-Niidome, Anne-Sophie Carlo, David M. Holtzman, Yu Kitago

Publikováno v: Science Translational Medicine. 6

SORLA/SORL1 is a unique neuronal sorting receptor for the amyloid precursor protein that has been causally implicated in both sporadic and autosomal dominant familial forms of Alzheimer's disease (AD). Brain concentrations of SORLA are inversely corr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ada35a76ff1e343e1a53b4080c76fc
https://doi.org/10.1126/scitranslmed.3007747

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Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases

Autor: Anne-Sophie Carlo, Thomas E. Willnow, Anders Nykjaer

Publikováno v: Carlo, A-S, Nykjaer, A & Willnow, T E 2014, ' Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases ', Journal of Molecular Medicine, vol. 92, no. 9, pp. 905-11 . https://doi.org/10.1007/s00109-014-1152-3

Sortilin is a sorting receptor that directs target proteins, such as growth factors, signaling receptors, and enzymes, to their destined location in secretory or endocytic compartments of cells. The activity of sortilin is essential for proper functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31400481245b51580b5954af4969bfff
https://pubmed.ncbi.nlm.nih.gov/24838608

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Sortilin, a novel APOE receptor implicated in Alzheimer disease

Autor: Anne-Sophie Carlo

Publikováno v: Prion. 7(5)

In the brain, apolipoprotein E (APOE) delivers cholesterol-rich lipoproteins to neurons to support synaptogenesis and maintenance of synaptic connections. Three APOE alleles exist in the human population with ε4 being an Alzheimer disease (AD) risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac83156189660ed26f9597873583f63c
https://pubmed.ncbi.nlm.nih.gov/23283348

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The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain

Autor: Michael Rohe, Tilman Burgert, Anne Sophie Carlo, Claus Munck Petersen, Thomas E. Willnow, Camilla Gustafsen, Anders Nykjaer, Joachim Herz, Guido Mastrobuoni, Morten Nielsen, Stefan Kempa, Joerg Heeren, Daniela Hartl

Publikováno v: Carlo, A-S, Gustafsen, C, Mastrobuoni, G, Nielsen, M S, Burgert, T, Hartl, D, Rohe, M, Nykjaer, A, Herz, J, Heeren, J, Kempa, S, Petersen, C M & Willnow, T E 2013, ' The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain ', Journal of Neuroscience, vol. 33, no. 1, pp. 358-70 . https://doi.org/10.1523/JNEUROSCI.2425-12.2013

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8252575beac345c6a25c2e841847b1b8
https://pubmed.ncbi.nlm.nih.gov/24121631

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