Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anne Schoenle"'
Autor:
Johannes Sam, Sara Colombetti, Tanja Fauti, Andreas Roller, Marlene Biehl, Linda Fahrni, Valeria Nicolini, Mario Perro, Tapan Nayak, Esther Bommer, Anne Schoenle, Maria Karagianni, Marine Le Clech, Nathalie Steinhoff, Christian Klein, Pablo Umaña, Marina Bacac
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/300bf113554b46c4a5d350084811b279
Autor:
Johannes Sam, Sara Colombetti, Tanja Fauti, Andreas Roller, Marlene Biehl, Linda Fahrni, Valeria Nicolini, Mario Perro, Tapan Nayak, Esther Bommer, Anne Schoenle, Maria Karagianni, Marine Le Clech, Nathalie Steinhoff, Christian Klein, Pablo Umaña, Marina Bacac
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
T-cell Bispecific Antibodies (TCBs) elicit anti-tumor responses by cross-linking T-cells to tumor cells and mediate polyclonal T-cell expansion that is independent of T-cell receptor specificity. TCBs thus offer great promise for patients who lack an
Externí odkaz:
https://doaj.org/article/62180c2dc7644782b45b5ddbc167bbfe
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Video 3. In vitro visualization of the dynamics of CD20-TCB (white) during interaction between CD8+ T-cells (green) and tumor cells (blue). The video focuses on an example of CD20-TCB-mediated CD8+ T-cell cytotoxicity of tumor cells. T-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c34bb5766e137770cfc15b52be8812
https://doi.org/10.1158/1078-0432.22470684.v1
https://doi.org/10.1158/1078-0432.22470684.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Figure 1. Assessment of the binding characteristics and cynomolgus monkey cross-reactivity of CD20-TCB. Supplemental Figure 2. Tumor cell lysis mediated by different CD20-targeting TCB antibodies. Supplemental Figure 3. T-cell and B-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f83b355ee080929db2938b3999bdc6
https://doi.org/10.1158/1078-0432.22470699.v1
https://doi.org/10.1158/1078-0432.22470699.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Video 1. In vitro visualization of the dynamics of untargeted TCB (white) during the interaction between CD8+ T-cells (green) and tumor cells (blue).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5528bbaeae8c4578de2abac8ea8e47c1
https://doi.org/10.1158/1078-0432.22470693.v1
https://doi.org/10.1158/1078-0432.22470693.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Purpose: Despite promising clinical activity, T-cell–engaging therapies including T-cell bispecific antibodies (TCB) are associated with severe side effects requiring the use of step-up-dosing (SUD) regimens to mitigate safety. Here, we present a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421e81a5be4c9af62b584bb4bcc20383
https://doi.org/10.1158/1078-0432.c.6527658
https://doi.org/10.1158/1078-0432.c.6527658
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental data details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257989830bf9a3ae734e9a5b265acd39
https://doi.org/10.1158/1078-0432.22470705.v1
https://doi.org/10.1158/1078-0432.22470705.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Video 2. In vitro visualization of the dynamics of CD20-TCB (white) during the interaction between CD8+ T-cells (green) and tumor cells (blue).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74444c2ec5be11dba70eb0e8147dca27
https://doi.org/10.1158/1078-0432.22470690.v1
https://doi.org/10.1158/1078-0432.22470690.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5594f5b3911dca8d52fd682a0acecc3f
https://doi.org/10.1158/1078-0432.22470696.v1
https://doi.org/10.1158/1078-0432.22470696.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Table 1. Overview of CD20-targeting T-cell bispecific molecules evaluated in the current study. Supplemental Table 2. Tumor cell lines and EC50 values of tumor cell lysis. Supplemental Table 3. Assessment of the activity in ex vivo prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f563536186d4caa72a439f6e060c463
https://doi.org/10.1158/1078-0432.22470708.v1
https://doi.org/10.1158/1078-0432.22470708.v1