Výsledky vyhledávání - "Anne Schaap-Nutt"

Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children

Autor: Ruth A, Karron, Kristi, Herbert, Kimberli, Wanionek, Alexander C, Schmidt, Anne, Schaap-Nutt, Peter L, Collins, Ursula J, Buchholz

Publikováno v: Journal of the Pediatric Infectious Diseases Society. 12:173-176

We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b656efbed84145ab260d42e643fa0585
https://doi.org/10.1093/jpids/piac137

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The Aberrant Gene-End Transcription Signal of the Matrix M Gene of Human Parainfluenza Virus Type 3 Downregulates Fusion F Protein Expression and the F-Specific Antibody Response In Vivo

Autor: Matthias Lingemann, Emerito Amaro-Carambot, Anne Schaap-Nutt, Sonja R. Surman, Shirin Munir, Peter L. Collins

Publikováno v: Journal of Virology. 89:3318-3331

Human parainfluenza virus type 3 (HPIV3), a paramyxovirus, is a major viral cause of severe lower respiratory tract disease in infants and children. The gene-end (GE) transcription signal of the HPIV3 matrix (M) protein gene is identical to those of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae2f67e5a648421cdd58f41f5bf1528
https://doi.org/10.1128/jvi.03148-14

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Chimeric Bovine/Human Parainfluenza Virus Type 3 Expressing Respiratory Syncytial Virus (RSV) F Glycoprotein: Effect of Insert Position on Expression, Replication, Immunogenicity, Stability, and Protection against RSV Infection

Autor: Ursula J. Buchholz, Peter L. Collins, Natalie Mackow, Lijuan Yang, Anne Schaap-Nutt, Emerito Amaro-Carambot, Sonja R. Surman, Shirin Munir, Bo Liang

Publikováno v: Journal of Virology. 88:4237-4250

A recombinant chimeric bovine/human parainfluenza type 3 virus (rB/HPIV3) vector expressing the respiratory syncytial virus (RSV) fusion F glycoprotein previously exhibited disappointing levels of RSV F immunogenicity and genetic stability in childre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87a3ab9827135e570ab035f37595d2a
https://doi.org/10.1128/jvi.03481-13

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Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium

Autor: Margaret A. Scull, Alexander C. Schmidt, Raymond J. Pickles, Rachael M. Liesman, Anne Schaap-Nutt, Peter L. Collins, Emmalene J. Bartlett

Publikováno v: Virology. 433:320-328

Human parainfluenza viruses (PIVs) cause acute respiratory illness in children, the elderly, and immunocompromised patients. PIV3 is a common cause of bronchiolitis and pneumonia, whereas PIV1 and 2 are frequent causes of upper respiratory tract illn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3da3f1b2bc37a91cb3cca549e9ca0e9
https://doi.org/10.1016/j.virol.2012.08.027

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Identification of Human Parainfluenza Virus Type 2 (HPIV-2) V Protein Amino Acid Residues That Reduce Binding of V to MDA5 and Attenuate HPIV-2 Replication in Nonhuman Primates

Autor: Caraline Higgins, Anne Schaap-Nutt, Christopher D'Angelo, Emerito Amaro-Carambot, Sheila M. Nolan, Brian R. Murphy, Peter L. Collins, Alexander C. Schmidt

Publikováno v: Journal of Virology. 85:4007-4019

Human parainfluenza virus type 2 (HPIV-2), an important pediatric respiratory pathogen, encodes a V protein that inhibits type I interferon (IFN) induction and signaling. Using reverse genetics, we attempted the recovery of a panel of V mutant viruse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e039cee493f66c0ba34235f0123a9ce0
https://doi.org/10.1128/jvi.02542-10

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Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates

Autor: Konrad C. Bradley, Christopher D'Angelo, Alexander C. Schmidt, Shenelle-Marie Wise, Peter L. Collins, Olivia S. Kim, Caraline Higgins, Mario H. Skiadopoulos, Brian R. Murphy, Reina Mayor, Sheila M. Nolan, Anne Schaap-Nutt, Emerito Amaro-Carambot, Stephanie D. Davis

Publikováno v: Virology. 406:65-79

The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 viru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4272729e7a6071d7970c5b34deb5e7
https://doi.org/10.1016/j.virol.2010.07.011

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Herpes simplex virus‐1 induces expression of a novel MxA isoform that enhances viral replication

Autor: Chia-Chi Ku, Yi-Yuan Chen, Marvin Sommer, Anne Schaap-Nutt, Mike Reichelt, Ke-Jung Huang, Ann M. Arvin, Xibing Che, Yi-Shun Chen, Jaya Rajamani

Publikováno v: Immunology & Cell Biology. 89:173-182

MxA is an antiviral protein induced by interferon (IFN)-α/β that is known to inhibit the replication of many RNA viruses. In these experiments, the 76-kDa MxA protein expressed in IFN-α-treated cells was shown to have antiviral activity against he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db140e857a7af3814ec6687d7064d332
https://doi.org/10.1038/icb.2010.83

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