Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anne Satterthwaite"'
Autor:
Mark Noviski, James L Mueller, Anne Satterthwaite, Lee Ann Garrett-Sinha, Frank Brombacher, Julie Zikherman
Publikováno v:
eLife, Vol 7 (2018)
Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown
Externí odkaz:
https://doaj.org/article/970ad69547ae4fccb96d3b59c0fd44ab
Autor:
Wei Luo, Jessica Mayeux, Toni Gutierrez, Andy Getahun, Jennifer Müller, Thomas Tedder, Shu-Hsia Chen, Robert Rickert, Lars Nitschke, John Cambier, Anne Satterthwaite, Lee Ann Garrett-Sinha
Publikováno v:
The Journal of Immunology. 192:45.7-45.7
Signaling through the B cell receptor (BCR) can drive B cell activation and contribute to B cell differentiation into antibody-secreting plasma cells. The positive BCR activation signal is counterbalanced by a number of membrane-localized inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5edf2e1fb920baed2b95c1930a54f134
https://doi.org/10.4049/jimmunol.192.supp.45.7
https://doi.org/10.4049/jimmunol.192.supp.45.7
Autor:
Jacqueline Wright, Emily Clark, Osamu Takeuchi, Sandra Zinkel, Anne Satterthwaite, Wasif Khan
Publikováno v:
The Journal of Immunology. 188:159.23-159.23
Autoreactive B cells are known to contribute to the onset and progression of a variety of autoimmune diseases including systemic lupus erythematosus (SLE). To prevent this, the B cell receptor (BCR) exerts specificity-based quality control and B cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52059e635c9e130454ade7dbff602ab3
https://doi.org/10.4049/jimmunol.188.supp.159.23
https://doi.org/10.4049/jimmunol.188.supp.159.23