Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Anne SIMONSEN"'
Autor:
Katharina Sporbeck, Maximilian L. Haas, Carmen J. Pastor-Maldonado, David S. Schüssele, Catherine Hunter, Zsuzsanna Takacs, Ana L. Diogo de Oliveira, Mirita Franz-Wachtel, Chara Charsou, Simon G. Pfisterer, Andrea Gubas, Patricia K. Haller, Roland L. Knorr, Manuel Kaulich, Boris Macek, Eeva-Liisa Eskelinen, Anne Simonsen, Tassula Proikas-Cezanne
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-23 (2023)
Abstract Human WIPI β-propellers function as PI3P effectors in autophagy, with WIPI4 and WIPI3 being able to link autophagy control by AMPK and TORC1 to the formation of autophagosomes. WIPI1, instead, assists WIPI2 in efficiently recruiting the ATG
Externí odkaz:
https://doaj.org/article/d0288956339a424480d31074800a3152
Autor:
Fulvio Reggiori, Patricia Boya, David da Costa, Zvulun Elazar, Eeva-Liisa Eskelinen, Judith Farrés, Sebastian Guettler, Claudine Kraft, Heinz Jungbluth, Ana Martinez, Etienne Morel, Ole Pless, Tassula Proikas-Cezanne, Anne Simonsen
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 414-417 (2022)
This animated movie presents the mechanism of macroautophagy, hereafter autophagy, by showing the molecular features of the formation of autophagosomes, the hallmark organelle of this intracellular catabolic pathway. It is based on our current knowle
Externí odkaz:
https://doaj.org/article/e97f74e4c78e439bbf87af65db04b52c
Autor:
Matthew Yoke Wui Ng, Chara Charsou, Ana Lapao, Sakshi Singh, Laura Trachsel-Moncho, Sebastian W. Schultz, Sigve Nakken, Michael J. Munson, Anne Simonsen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The functions of specific lipids in autophagosome biogenesis are not entirely clear. Here, the authors show that the ER protein GRAMD1C, a cholesterol transport protein, suppresses autophagy initiation and has roles in mitochondrial cholesterol homeo
Externí odkaz:
https://doaj.org/article/e7fede4d4b1c4ef589afdf61c6e3f288
Autor:
Michael J. Munson, Benan J. Mathai, Matthew Yoke Wui Ng, Laura Trachsel-Moncho, Laura R. de la Ballina, Sebastian W. Schultz, Yahyah Aman, Alf H. Lystad, Sakshi Singh, Sachin Singh, Jørgen Wesche, Evandro F. Fang, Anne Simonsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remain elusive. Here the authors use an siRNA library to screen lipid-binding proteins, and identify the kinases GAK and PRKCD as positive regulators of PRKN
Externí odkaz:
https://doaj.org/article/b12ee5952fc74880a26b3fbe78bc34b0
Autor:
Mohummad Aminur Rahman, Agnete S. T. Engelsen, Shahin Sarowar, Christian Bindesbøll, Even Birkeland, Dorota Goplen, Maria L. Lotsberg, Stian Knappskog, Anne Simonsen, Martha Chekenya
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Introduction: Glioblastoma (GBM) is invariably resistant to temozolomide (TMZ) chemotherapy. Inhibiting the proteasomal pathway is an emerging strategy to accumulate damaged proteins and inhibit their lysosomal degradation. We hypothesized that pre-t
Externí odkaz:
https://doaj.org/article/97450fdd4e974ae4b33bae35e382b09f
Autor:
Petter Holland, Helene Knævelsrud, Kristiane Søreng, Benan J. Mathai, Alf Håkon Lystad, Serhiy Pankiv, Gunnveig T. Bjørndal, Sebastian W. Schultz, Viola H. Lobert, Robin B. Chan, Bowen Zhou, Knut Liestøl, Sven R. Carlsson, Thomas J. Melia, Gilbert Di Paolo, Anne Simonsen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Autophagy must be tightly controlled at each step of the process. Here the authors show that HS1BP3 binds phosphatidic acid (PA) at autophagosome precursors and negatively regulates autophagosome formation by modulating the activity and localization
Externí odkaz:
https://doaj.org/article/f353cc30440843249f823e8e4c1b2f7c
Autor:
Aleksander Aas, Pauline Isakson, Christian Bindesbøll, Endalkachew A Alemu, Arne Klungland, Anne Simonsen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0168182 (2017)
Polymorphic variants of the FTO (fat mass and obesity) gene associate with body mass index in humans, but the underlying molecular mechanisms have not been firmly determined. FTO is linked to energy homeostasis via amino acid sensing and is thought t
Externí odkaz:
https://doaj.org/article/adf7c6a49c04485a888e028535ee3ef4
Autor:
Alf Håkon Lystad, Anne Simonsen
Publikováno v:
Cells, Vol 8, Iss 9, p 973 (2019)
Since their initial discovery around two decades ago, the yeast autophagy-related (Atg)8 protein and its mammalian homologues of the light chain 3 (LC3) and γ-aminobutyric acid receptor associated proteins (GABARAP) families have been key for the tr
Externí odkaz:
https://doaj.org/article/3b3690a6497a4faf9deb4a17f67f3585
Autor:
Joanna M Dragich, Takaaki Kuwajima, Megumi Hirose-Ikeda, Michael S Yoon, Evelien Eenjes, Joan R Bosco, Leora M Fox, Alf H Lystad, Tinmarla F Oo, Olga Yarygina, Tomohiro Mita, Satoshi Waguri, Yoshinobu Ichimura, Masaaki Komatsu, Anne Simonsen, Robert E Burke, Carol A Mason, Ai Yamamoto
Publikováno v:
eLife, Vol 5 (2016)
The regulation of protein degradation is essential for maintaining the appropriate environment to coordinate complex cell signaling events and to promote cellular remodeling. The Autophagy linked FYVE protein (Alfy), previously identified as a molecu
Externí odkaz:
https://doaj.org/article/bebc1d11f6ea4e1fa0d10407c60fe990
Autor:
Ai Yamamoto, Anne Simonsen
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 17-28 (2011)
The presence of ubiquitinated protein inclusions is a hallmark of most adult onset neurodegenerative disorders. Although the toxicity of these structures remains controversial, their prolonged presence in neurons is indicative of some failure in fund
Externí odkaz:
https://doaj.org/article/b0ff618903d24795a499badf1becd5d6