Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anne S. Haugaard"'
Autor:
Sascha Jung, Petrine Wellendorph, Gitte M. Knudsen, Anne S. Haugaard, Elina T. L’Estrade, Christina Birkedahl Falk-Petersen, Bente Frølund, Matthias M. Herth, Nane Griem-Krey, Tomas Ohlsson, Maria Erlandsson, Hartmut Lüddens, Tanja Schirmeister, Hanne D. Hansen
Publikováno v:
ACS Omega, Vol 4, Iss 5, Pp 8846-8851 (2019)
L'Estrade, E T, Hansen, H D, Falk-Petersen, C, Haugaard, A, Griem-Krey, N, Jung, S, Lueddens, H, Schirmeister, T, Erlandsson, M, Ohlsson, T, Knudsen, G M, Herth, M M, Wellendorph, P & Frolund, B 2019, ' Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors ', ACS Omega, vol. 4, no. 5, pp. 8846-8851 . https://doi.org/10.1021/acsomega.9b00434
L'Estrade, E T, Hansen, H D, Falk-Petersen, C, Haugaard, A, Griem-Krey, N, Jung, S, Lueddens, H, Schirmeister, T, Erlandsson, M, Ohlsson, T, Knudsen, G M, Herth, M M, Wellendorph, P & Frolund, B 2019, ' Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors ', ACS Omega, vol. 4, no. 5, pp. 8846-8851 . https://doi.org/10.1021/acsomega.9b00434
The α4/6βδ-containing GABAA receptors are involved in a number of brain diseases. Despite the potential of a δ-selective imaging agent, no PET radioligand is currently available for in vivo imaging...
Autor:
Louise Thiesen, Bente Frølund, Anas Al-Khawaja, Maria Damgaard, Aleš Marek, Christoffer Bundgaard, Petrine Wellendorph, Anne S. Haugaard, Mònica Santiveri, Rebekka Löffler
Publikováno v:
ACS Chemical Neuroscience. 9:545-554
The betaine/γ-aminobutyric acid (GABA) transporter 1 (BGT1) is one of the four GABA transporters (GATs) involved in the termination of GABAergic neurotransmission. Although suggested to be implicated in seizure management, the exact functional impor
Autor:
Rasmus P. Clausen, Claus H. Jensen, Sara Björk Sigurdardóttir, Kenneth T. Kongstad, David E. Gloriam, Petrine Wellendorph, Mia Nittegaard-Nielsen, Christina Birkedahl Falk-Petersen, Francesco Bavo, Yongsong Tian, Jan Kehler, Kasper Harpsøe, Jacob Krall, Stine B. Vogensen, Bente Frølund, Anne S. Haugaard
Publikováno v:
Journal of Medicinal Chemistry. 60:9022-9039
γ-hydroxybutyric acid (GHB) is a neuroactive substance with specific high-affinity binding sites. To facilitate target identification and ligand optimization, we herein report a comprehensive structure-affinity relationship study for novel ligands t
Autor:
Stefanie Kickinger, Maria Damgaard, Anas Al-Khawaja, Rebekka Löffler, Gerhard F. Ecker, Maria E. K. Lie, Bente Frølund, Petrine Wellendorph, Anne S. Haugaard, Francesco Bavo
Publikováno v:
Biophysical Journal. 118:130a
Autor:
Hartmut Lüddens, Helen Damerow, Judith Weber, Bente Frølund, Annika Kretzschmann, Sascha Jung, Frank Rösch, Markus Piel, Kirsten Yakoub, Anne S. Haugaard, Tanja Schirmeister, Aylin Sibel Cankaya, Christian Sattler
Publikováno v:
Journal of medicinal chemistry. 61(5)
δ-Selective compounds 1 and 2 (DS1, compound 22; DS2, compound 16) were introduced as functionally selective modulators of δ-containing GABA type A receptors (GABAAR). In our hands, [3H]EBOB-binding experiments with recombinant GABAAR and compound
Autor:
Anas, Al-Khawaja, Anne S, Haugaard, Ales, Marek, Rebekka, Löffler, Louise, Thiesen, Mònica, Santiveri, Maria, Damgaard, Christoffer, Bundgaard, Bente, Frølund, Petrine, Wellendorph
Publikováno v:
ACS chemical neuroscience. 9(3)
The betaine/γ-aminobutyric acid (GABA) transporter 1 (BGT1) is one of the four GABA transporters (GATs) involved in the termination of GABAergic neurotransmission. Although suggested to be implicated in seizure management, the exact functional impor
Autor:
Maria E K, Lie, Anas, Al-Khawaja, Maria, Damgaard, Anne S, Haugaard, Arne, Schousboe, Andrew N, Clarkson, Petrine, Wellendorph
Publikováno v:
Advances in neurobiology. 16
Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABA
Autor:
Maria E. K. Lie, Stefanie Kickinger, Anas Al-Khawaja, Rasmus P. Clausen, Bente Frølund, Anne S. Haugaard, Gerhard F. Ecker, Maria Damgaard
Publikováno v:
Advances in Neurobiology ISBN: 9783319557670
γ-Aminobutyric acid (GABA) neurotransmission is terminated by the GABA transporters (GATs) via uptake of GABA into neurons and surrounding glial cells. Four different transporters have been identified: GAT1, GAT2, GAT3, and the betaine/GABA transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0283be0cd968692d430f33e97fde8a
https://doi.org/10.1007/978-3-319-55769-4_16
https://doi.org/10.1007/978-3-319-55769-4_16
Autor:
Anas Al-Khawaja, Maria E. K. Lie, Andrew N. Clarkson, Petrine Wellendorph, Maria Damgaard, Arne Schousboe, Anne S. Haugaard
Publikováno v:
Advances in Neurobiology ISBN: 9783319557670
Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABAA receptors that sense ambient GABA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb72cc7fd2e7addf54933b12220f7b47
https://doi.org/10.1007/978-3-319-55769-4_7
https://doi.org/10.1007/978-3-319-55769-4_7